معرفی
Astrid G. Stucke, MD, is a Professor at the Medical College of Wisconsin (MCW) and a staff anesthesiologist at Children's Wisconsin. Her research focuses on the central control of breathing, particularly the effects of anesthetics, opioids, and hypoxia on respiratory neurons in the brainstem. She explores mechanisms underlying opioid-induced respiratory depression and neonatal hypoxia, leveraging animal models (dogs, rabbits, swine). Her work is supported by NIH and VA grants. Clinical roles include pediatric anesthesia and operating room duties.
Education:
- Medical Doctorate: University of Heidelberg, Germany
- Residency: Anesthesiology at MCW
- Fellowship: Pediatric Anesthesia at MCW
Research Themes: Dr. Stucke investigates:
- Neurotransmission modulation by volatile anesthetics in respiratory premotor neurons
- Effects of clinically relevant opioid concentrations on brainstem neurons
- Hypoxia mechanisms in immature mammals and anesthesia impacts across developmental stages
- Pharmacological interventions targeting opioid-induced respiratory depression
Key Contributions: Her lab uses extracellular recordings and drug ejection techniques in in vivo models. Recent studies include development of a SPORC-C score predicting postoperative respiratory complications in children. Collaborations span neuroscience, pharmacology, and biomedical engineering.
Labs/Teams: Part of Drs. Zuperku/Stuth's group and leads her own neonatal hypoxia research team. Active in multidisciplinary collaborations at MCW and Children's Wisconsin.
