Antonio Costanzo

Antonio Costanzo is Full Professor of Dermatology at Humanitas University, Director of the School of Specialization in Dermatology, and Director of the Skin Pathology Laboratory. He also serves as Head of the Dermatology Clinical Unit at Humanitas Research Hospital and Board Member of the European Dermatology Forum.

His academic credentials include:

• MD in Medicine and Surgery from University of Rome, La Sapienza (1994)
• Specialization in Internal Medicine (1999)
• Specialization in Dermatology (2006)

Professor Costanzo's research integrates clinical investigations of biologic drugs in psoriasis and atopic dermatitis with basic science explorations of pathogenic mechanisms including TNF signaling, NF-kappaB regulation, and IL-21-mediated keratinocyte proliferation. Current projects feature epigenetic mapping of keratinocytes in atopic dermatitis (IMMUNIVERSE project), development of genetic markers for biologic response prediction, and optoacoustic imaging innovation through the EU-funded WINTHER project.

His extensive publication record demonstrates consistent focus on real-world evidence for biologics and JAK inhibitors across immune-mediated skin diseases, with recent studies analyzing drug effectiveness, safety profiles, and personalized treatment strategies for diverse patient subgroups including elderly populations and those with comorbidities.

As leader of the Skin Pathology Lab and Costanzo Group, he oversees molecular research on immune-mediated cutaneous diseases using epigenetic analysis and gene regulation techniques, with active staff scientists contributing to enhancer mapping in keratinocytes and inflammatory microenvironments.