Anton Calabrese

Dr Anton Calabrese is a University Academic Fellow in Biological Mass Spectrometry at the University of Leeds, affiliated with the Faculty of Biological Sciences and the School of Molecular and Cellular Biology. His research focuses on the structural and dynamic characterization of complex biological systems using advanced mass spectrometry techniques.

His research interests lie at the intersection of structural biology, proteomics, and cellular dynamics. He specializes in studying transient and heterogeneous protein assemblies that are central to essential cellular functions and disease mechanisms. Using an integrative structural biology approach, he combines native mass spectrometry with ion mobility, chemical crosslinking, hydrogen-deuterium exchange, and FPOP to probe protein conformations and interactions in dynamic systems.

Dr Calabrese's work targets key biological challenges, including the assembly mechanisms of viral replication factories in pathogens like Rotavirus, the structural basis of liquid-liquid phase separation (LLPS) in membrane-less organelles, and the role of protein dynamics in neurodegenerative diseases such as ALS and FTLD. He is also developing in-cell structural MS methodologies to study protein architecture within the native cellular environment.

His research has significant implications for understanding fundamental biological processes and identifying novel therapeutic targets, particularly in virology and neurodegeneration. While no specific awards or publications are listed, his methodological innovations position him at the forefront of structural proteomics and dynamic structural biology.

• Position: University Academic Fellow in Biological Mass Spectrometry
• Institution: University of Leeds
• Faculty: Biological Sciences
• School: School of Molecular and Cellular Biology
• Location: Astbury 9.108g
• Contact: a.calabrese@leeds.ac.uk | +44(0) 113 343 7272

Dr Calabrese leads an independent research program focused on method development and application in structural mass spectrometry. His lab aims to bridge the gap between in vitro and in vivo structural biology by refining techniques such as XL-MS and FPOP for intracellular use, enabling real-time analysis of macromolecular assemblies in their native context.