Annika Weile Nonboe

Annika Weile Nonboe serves as Academic Research Staff and Guest Researcher within the Department of Cellular and Molecular Medicine at the University of Copenhagen's Faculty of Health and Medical Sciences. Her work is centered in the Morphogenesis and Differentiation Program under the Vogel Group, focusing on protease-inhibitor dynamics in cancer pathways.

Her research investigates the interplay between serine proteases matriptase and prostasin with their inhibitors HAI-1 and HAI-2, aiming to develop novel cancer therapeutics. Key areas include proteolytic regulation in epithelial homeostasis, matriptase zymogen activation mechanisms, and the role of HAI proteins in congenital disorders like tufting enteropathy. Her work bridges molecular oncology, gastrointestinal pathophysiology, and protease network biology.

Dr. Nonboe's publication record demonstrates consistent contributions to biochemical and cellular journals, with emphasis on cancer protease systems. Her 2013-2022 output reveals progressive deepening into HAI protein functions, particularly HAI-2's dual roles in matriptase stabilization and prostasin regulation. Recent work explores clinical connections to colorectal carcinogenesis and sodium diarrhea disorders.

Collaborative networks are evident through multi-author publications with international teams across Denmark, Austria, and Japan. Her research receives significant attention with over 150 combined Scopus citations and Mendeley readership, indicating impact in molecular cancer research circles.