معرفی
Anne E. Luebke, Ph.D., is an Associate Professor in the Departments of Biomedical Engineering and Neuroscience at the University of Rochester School of Medicine and Dentistry (SMD). Her research focuses on auditory and vestibular efferent systems, exploring molecular mechanisms underlying hearing and hearing loss. She holds a PhD in Bioengineering from Johns Hopkins University and completed postdoctoral training in Molecular Neuroscience at the University of Miami School of Medicine.
Her laboratory investigates cochlear outer hair cells' roles in sound processing, with a focus on neurotransmitter receptors (e.g., α9 nicotinic acetylcholine receptors and CGRP receptors) and their protective roles against noise-induced hearing loss. She pioneered viral-mediated gene transfer techniques to study these systems, using adenoviral vectors to modulate receptor expression in vivo without cochlear damage.
Key research areas include: cochlear efferent protection, CGRP signaling in vestibular and auditory systems, and the impact of musical training on auditory processing. Her work spans from molecular biology to systems neuroscience, with translational goals in developing therapies for hearing loss and vestibular disorders.
Luebke has received continuous NIH funding since 1996 and holds affiliations with the Del Monte Institute for Neuroscience, Biomedical Engineering Ph.D. Program, and Neurobiology & Anatomy Ph.D. Program. Notable awards include the Dean's Award for Young Laboratory Research Scientist (2001) and NIH postdoctoral fellowship (1991–1993).
Her lab's current projects include studying RAMP1 overexpression in migraine models, age-related vestibular deficits, and the efficacy of 'gepant' antagonists. Collaborators span institutions like the University of Miami and Johns Hopkins, with publications in Journal of Neuroscience, eNeuro, and Frontiers in Neuroscience.
