معرفی
Anne Dejean is a leading research scientist and Professor at the Institut Pasteur in Paris, where she leads the 'Régulation Spatiale des Génomes' (Spatial Regulation of Genomes) laboratory within the Department of Genomes and Genetics. Her work bridges fundamental epigenetics with translational applications in cancer and regenerative medicine. She is Principal Investigator of multiple high-profile projects, including ERC-AdG SUMOSTRESS and ERC-AdG SUMiDENTITY, focusing on the role of SUMOylation in chromatin regulation, cell identity, and disease.
Her research interests center on understanding the epigenetic and cellular mechanisms governing normal and pathological cell fates, with a strong emphasis on early embryonic development and cancer. Key areas include:
- Sumoylation as a guardian of cellular identity
- Chromatin dynamics in transcriptional regulation
- Cellular plasticity in development and tumorigenesis
- Reprogramming of cancer cells
- Development of synthetic embryos
- Molecular epidemiology of hepatocellular carcinoma
The recent publications highlight a strong trend in using cutting-edge molecular and genomic techniques—such as single-cell 'omics', genome editing, and chromatin biochemistry—to explore how SUMOylation regulates cell fate transitions. Her work spans from basic mechanisms in stem cells to clinical applications in liver cancer, particularly in understudied populations with Indigenous American ancestry. The integration of synthetic biology, epigenetics, and disease modeling underscores a multidisciplinary approach aimed at developing novel therapeutic strategies.
Anne Dejean has received significant research funding from the European Research Council and leads a dynamic team of researchers. She actively mentors PhD students and postdoctoral fellows, contributing to the training of the next generation of scientists.
Her laboratory is involved in several collaborative initiatives, including the 'Initiative Cellules Souches' and 'Initiative Cancer' at the Institut Pasteur, reflecting her engagement in large-scale interdisciplinary efforts in stem cell biology and oncology.
