Anna Bruchez

Anna Bruchez, PhD, is an Assistant Professor in the Department of Pathology at the School of Medicine, Case Western Reserve University. Her research focuses on understanding viral pathogenesis through unbiased genetic screening approaches, targeting RNA viruses like Ebolavirus and Coronaviruses. The Bruchez Lab employs high-throughput screens to identify host-virus interactions and innate immune mechanisms that hinder viral replication, utilizing BSL3 facilities for studies involving SARS-CoV-2. Key areas of investigation include viral entry mechanisms, host resistance pathways, and antiviral strategies.

Research interests center on emerging viral pathogens, with a focus on uncovering novel cellular pathways that modulate infection outcomes. Techniques include forward genetic screening, CRISPR-based mutagenesis, and biochemical assays to dissect virus-host interactions. The lab's work contributes to both fundamental virology and potential therapeutic development.

Recent publications highlight studies on ACE2 receptor dependencies for coronaviruses, identification of host factors like CIITA and NPC1 in viral resistance, and development of antiviral inhibitors through small molecule screening. No specific scientific awards are listed in the provided materials.

Labs/teams: The Bruchez Lab operates within the Department of Pathology, leveraging advanced molecular biology tools and containment facilities to address critical questions in virology. Current projects aim to reveal molecular mechanisms underlying viral entry and host defense, with applications toward combating emerging infectious diseases.