معرفی
Ann Haberman, PhD is an Associate Professor of Immunobiology at Yale School of Medicine. She holds dual leadership roles as Director of the In Vivo Imaging Facility and Scientific Director of the Flow Cytometry Research Facility at YSM. Her research focuses on understanding cellular and molecular mechanisms governing germinal center formation, B cell activation, and lymphocyte interactions in immune responses. Haberman earned her PhD in Immunology from the University of Pennsylvania (1992).
Research Interests: Dr. Haberman's work investigates how germinal centers regulate antibody production and immune memory through intricate cell-cell interactions. Her lab uses advanced imaging technologies to study B cells, dendritic cells, and stromal niches in vivo, with particular emphasis on T cell help dynamics and lymphoma pathogenesis. Key areas include:
- Germinal center B cell development
- Role of IL-21/IL-4 cytokines
- Epigenetic regulation via BCL6
- Mammary gland involution mechanisms
- Lymphoma formation pathways
Key Contributions: Over 30 peer-reviewed publications since 2009 highlight her expertise in immunological synapses, live tissue imaging, and virological research. Notable work includes defining B cell selection mechanisms in germinal centers and elucidating LSD1's role in lymphomagenesis. Her imaging facilities support interdisciplinary research across immunology, cancer biology, and developmental biology.
Lab Facilities: Directs cutting-edge resources at Yale including:
- In Vivo Imaging Facility (multiphoton microscopy)
- Flow Cytometry Core Facility
