Andrey Krasilnikov

Andrey Krasilnikov is a Professor of Biochemistry and Molecular Biology at Pennsylvania State University. His research focuses on the structural and functional analysis of RNA-protein complexes, particularly ribonucleases P and MRP, and their roles in RNA processing and cellular regulation. He holds affiliations with the BMMB Graduate Program and the Center for RNA Biology.

Education:

• 1991: Degree Cum Laude, Moscow Institute of Physics and Technology

Research Interests: Structural biology of RNA and RNA-protein complexes, including the mechanisms of catalysis, substrate recognition, and assembly of RNase P and MRP. His work employs advanced techniques like cryo-EM, UV-crosslinking, and X-ray crystallography to understand these complexes' molecular architectures.

Key Research Trends: Over 15 years, his publications emphasize structural elucidation of RNase P/MRP components (e.g., P3 domain), interactions between proteins (Pop1, Pop5/Rpp1) and RNA substrates, and comparisons between yeast telomerase and RNase systems. Recent studies (2020) reveal the cryo-EM structure of RNase MRP, advancing understanding of catalytic RNPs.

Awards: Notable honors include the 2016 Daniel R. Tershak Award for Excellence in Teaching and the 2006 Beckman Young Investigator Award. His 2007 March of Dimes award was declined but underscores recognition of his early-career contributions.

Grants & Advising: While specific grant details aren't listed, his publications reflect sustained NIH/NIGMS (National Research Service Award) and foundation support. No explicit student advisees are named in the provided texts.

Labs/Teams: Active in the Center for RNA Biology, collaborating on structural biology projects involving RNA-protein complexes.