معرفی
Andrea Nicola Mazzarello is a Researcher in the Department of Experimental Medicine at the University of Genoa, teaching Human Anatomy, Neuroanatomy, and Anatomy of the Stomathognathic System across Dental Hygiene, Nursing, and Biotechnology degree programs.
His research centers on Chronic Lymphocytic Leukemia (CLL), investigating molecular pathways including p53/xCT/GSH axis dysregulation, Pentose Phosphate Pathway metabolism, mitochondrial dynamics, and viral infection impacts on B-cell pathophysiology. Key focus areas include chemotherapy resistance mechanisms and therapeutic target identification.
Recent publications demonstrate a cohesive trend toward targeting metabolic vulnerabilities in CLL, with emphasis on drug combinations (e.g., PRIMA-1Met/sulfasalazine), bisphosphonate-induced B-cell activation, and SARS-CoV-2 interactions with CLL pathophysiology. This work bridges basic science and translational oncology applications.
