Andrea Kühn

Prof. Dr. Andrea Kühn serves as Director of the Section for Movement Disorders and Neuromodulation at Charité – Universitätsmedizin Berlin, leading clinical and research activities across the Charité Mitte Campus (CCM) and Virchow-Klinikum Campus (CVK). As a professor of neurology since 2007, she oversees treatment for approximately 1,000 movement disorder patients annually through specialized clinics for Parkinson's disease, tremor, and dystonia, including deep brain stimulation (DBS) and botulinum toxin therapy programs.

Her research program investigates the neurophysiological basis of movement disorders with particular focus on neuronal oscillations in basal ganglia circuits and the mechanism of action of deep brain stimulation. Prof. Kühn employs a multidisciplinary approach integrating clinical-neurophysiological studies, non-invasive stimulation techniques, sensor-based movement analysis, imaging research, and animal studies to develop more effective neuromodulation therapies. Since 2020, she has directed the transregional Collaborative Research Center TRR 295 ReTune, a €10 million initiative funded by the German Research Foundation that brings together researchers from multiple institutions to advance network-specific neuromodulation methods.

Analysis of Prof. Kühn's recent publication record reveals a strong emphasis on understanding electrophysiological biomarkers for DBS therapy, particularly how local field potentials correlate with motor performance in Parkinson's disease. Her work increasingly incorporates computational modeling, network analysis, and personalized neuromodulation approaches to optimize treatment for movement disorders, with growing focus on extending these techniques beyond motor symptoms to address non-motor aspects of neurological conditions.

Notable scientific achievements include:

• Development of LEAD-DBS software for precise electrode localization in DBS procedures, which received the Max-Rubner-Preis of the Charité Foundation in 2013
• Leadership of the TRR 295 ReTune Collaborative Research Center with €10 million funding from the German Research Foundation
• Creation of a certified Class 1 medical device from research software used globally for DBS planning

Prof. Kühn manages an extensive research program with numerous national and international collaborations across eight institutions. Her section operates within the Department of Neurology with Experimental Neurology across three Charité campuses, conducting clinical trials and translational research projects that bridge basic neuroscience with patient care. The team comprises senior physicians, researchers, and technical staff working on various aspects of movement disorder research and treatment development.

The Movement Disorders and Neuromodulation Section maintains advanced research facilities for clinical neurophysiology, imaging analysis, and animal studies. It collaborates closely with the Center for Stroke Research Berlin and participates in the NeuroCure Cluster of Excellence, contributing to Berlin's reputation as a leading center for neurological research and innovation in neuromodulation therapies.