Andre Levchenko

Andre Levchenko is the John C. Malone Professor of Biomedical Engineering at Yale University, with secondary appointments in Neurosurgery and affiliations spanning the Yale Cancer Center (Cancer Signaling Networks Program), Systems Biology Institute (Director), Yale Biomedical Imaging Institute, and Program in Neurodevelopment and Regeneration. His lab employs interdisciplinary approaches integrating systems biology, microfluidics, and computational modeling to investigate cellular decision-making.

Research focuses on three interconnected themes:

• Dynamic signaling networks: Decoding VEGF/YAP crosstalk in angiogenesis, NOTCH spatiotemporal patterning, and oscillations in HIF-1α during hypoxia
• Cancer mechanisms: Ion transport in glioblastoma invasion, metabolic adaptations in tumors, and therapeutic targeting of transcriptional networks
• Stem cell & developmental engineering: Brain organoid specification using WNT/SHH gradients, mechanobiology of stem cell differentiation, and CRISPR-engineered models

Publication analysis reveals consistent emphasis on quantitative approaches to cell signaling (60% of recent work), cancer biophysics (30%), and neurodevelopmental engineering (10%), with frequent use of single-cell analysis, microfluidics, and mathematical modeling.

Major scientific recognitions include:

• Burroughs Wellcome Fund Fellowship (1999-2001)
• American Asthma Foundation Early Excellence Award (2010)
• Elected Fellow, American Institute for Medical and Biological Engineering (2013)

The Levchenko Lab at Yale's Systems Biology Institute hosts graduate students and postdocs pursuing projects at the interface of engineering, systems biology, and translational medicine. Active collaborations extend to neurosurgeons, oncologists, and stem cell biologists across Yale.