Amy W Tasca

Amy W Tasca is a Clinical Associate Professor in the Department of Orthodontics at the School of Dentistry, University of Minnesota. Her work integrates clinical orthodontics with molecular and cellular bone biology, focusing on osteoclastogenesis and skeletal site-specific differences in bone remodeling. She actively leads research projects and contributes to peer-reviewed literature in both dental and biomedical sciences.

Research Interests:

• Osteoclast differentiation and function
• Skeletal site-specific myeloid cell behavior
• Gene expression in mandibular vs. femoral osteoclast precursors
• Single-cell RNA sequencing in bone biology
• Orthodontic treatment outcomes and patient comfort
• Molecular mechanisms of BMP/SMAD signaling in bone

The recent articles highlight a strong trend in comparative osteoclast biology between jaw and long bones, using advanced genomic techniques. Her research bridges clinical orthodontics with fundamental bone biology, contributing to both patient care and mechanistic understanding of skeletal remodeling.

Scientific Awards:

• No awards explicitly mentioned in the text.

Advising and Grants:
Amy W Tasca serves as Principal Investigator on multiple funded research projects. These include:

• Comparison of oral health and patient comfort outcomes for Phase I Invisalign and fixed appliance patients (ALIGN TECHNOLOGY, INC, 2022–2025)
• Where you originate from matters; A Comparison of Jaw and Long Bone Osteoclast Precursors Using Single Cell Analysis (American Association of Orthodontists Foundation, 2022–2023)
• The role of MyosinX in BMPs promotion of SMAD 1/5 in ost (NIH NIDCR, 2014–2016)

She has not listed any formal advisees in the provided text.

Labs and Teams:
Dr. Tasca collaborates closely with Dr. Kenneth Mansky and other researchers in bone biology and myeloid cell research. Her work involves single-cell analysis and molecular techniques, likely conducted within a specialized bone biology or dental research laboratory at the University of Minnesota.