Amy K. Mottl

Amy K. Mottl serves as Professor of Medicine in the Division of Nephrology and Hypertension at the University of North Carolina School of Medicine. Her clinical practice focuses on diabetic kidney disease (DKD), glomerular disorders, and genetic kidney conditions including Fabry Disease and Autosomal Dominant Polycystic Kidney Disease.

Education:

• Undergraduate: Northeastern University
• MD: Albert Einstein College of Medicine (Yeshiva University), 1999 (Alpha Omega Alpha)
• Residency: Internal Medicine, University of North Carolina at Chapel Hill, 2002
• Nephrology Fellowship: University of North Carolina at Chapel Hill, 2005
• MPH: Epidemiology, UNC School of Public Health, 2006

Dr. Mottl's research centers on the epidemiology and pathogenesis of diabetic kidney disease and glomerular disorders. She leads clinical trials for phase II/III studies in diabetes-CKD therapeutics and serves as Principal Investigator for the NIDDK-sponsored Kidney Precision Medicine Program. Her work emphasizes health equity, multidisciplinary care coordination, and expanding access to cardiorenal-protective medications.

Key research initiatives:

• Investigator for SEARCH for Diabetes in Youth Study
• TRIDENT longitudinal DKD biopsy cohort
• Cure-Glomerulopathy Network (CureGN) natural history study
• R01 ancillary study on diabetes in glomerular disease
• PAGE Study co-investigator for genetic/epigenetic kidney disease associations

She maintains active clinical roles in DKD, vasculitis, and glomerulonephritis management while advancing genetic epidemiology methodologies in diverse populations.