معرفی
Amy Arnsten is the Albert E. Kent Professor of Neuroscience and Professor of Psychology at Yale School of Medicine, with secondary appointments in the Child Study Center and Department of Psychiatry. She is a member of the Kavli Institute of Neuroscience at Yale University and the National Academy of Medicine.
- Primary Appointment: Department of Neuroscience, Yale School of Medicine
- Secondary Appointments: Child Study Center, Department of Psychology, Department of Psychiatry
- Organizational Affiliations: Alzheimer's Disease Research Center, Center for Brain & Mind Health, Wu Tsai Institute, Yale Center for Research on Aging
Dr. Arnsten's research focuses on molecular regulation of prefrontal cortical circuits, particularly how neuromodulators like norepinephrine and dopamine influence working memory through Dynamic Network Connectivity mechanisms. Her work has revealed how stress, aging, and genetic mutations disrupt these pathways, leading to cognitive disorders in Alzheimer's disease, schizophrenia, and ADHD. She pioneered the development of guanfacine (Intuniv™) for ADHD treatment based on her molecular insights.
Her recent publications (2024-2025) demonstrate a strong focus on Alzheimer's disease mechanisms, particularly tau pathology propagation in primate models, calcium dysregulation in aging neurons, and translational biomarker development. Key themes include vulnerable prefrontal neuron populations, synaptic density measurement, and molecular targets for cognitive enhancement.
- Member, National Academy of Medicine (2017)
- Goldman-Rakic Prize for Outstanding Achievement in Cognitive Neuroscience (2015)
Dr. Arnsten leads the Arnsten Lab, which employs multi-disciplinary approaches including primate neuroanatomy, molecular signaling analysis, and behavioral testing. Her research has direct clinical applications, with discoveries translating to treatments for ADHD, PTSD, and cognitive deficits in aging. Current work focuses on preventing early-stage tau pathology and developing novel cognitive enhancers targeting glutamate and calcium signaling pathways.