Amanda Harrington

Amanda Harrington, MD, serves as Assistant Professor in the Department of Pediatrics at the University of Kentucky College of Medicine, with dual appointments as Member of the Markey Cancer Center and Translational Oncology Research Program. Her clinical and research focus centers on inherited cancer syndromes in pediatric populations.

Education:

• Post Doctoral Fellow, Emory University (2020)
• Residency, Tufts University (2017)
• Doctor of Medicine, Medical College Of Georgia (2014)
• Bachelor of Science, University Of Georgia (2010)

Dr. Harrington's research investigates nuclear export mechanisms (particularly CRM1/XPO1) in cancer development, with emphasis on chromosome biology and inherited predisposition syndromes. Her work bridges molecular oncology and clinical pediatrics through projects addressing genetic risk assessment and caregiver quality-of-life interventions for families with cancer syndromes. Current studies explore how nuclear pore complex dysfunction contributes to leukemogenesis and intracranial tumors.

Her 2024 review on CRM1 inhibitors demonstrates consistent focus on molecular targeting strategies across her publication record, highlighting therapeutic applications in pediatric oncology and chromosome-related malignancies.

Grants & Leadership:

• Co-Investigator for 6 active projects (2022-2026) including NCI-funded "CCSG Pilot: Addressing An Unmet Need" (2023-2025)
• Principal collaborator on KY Cabinet for Health and Family Services' Inherited Cancer Risk Program (2022-2026)
• Focus areas: Germline mutation analysis, childhood cancer genetics, and clinical risk management protocols

Dr. Harrington contributes to the Markey Cancer Center's Translational Oncology Research Program through multidisciplinary teams developing clinical frameworks for inherited cancer syndromes, with active collaborations spanning University of Kentucky, University of Louisville, and national pediatric oncology networks.