Alison J. Scott

Alison J. Scott is an Assistant Professor at the University of Maryland, Baltimore School of Dentistry in the Department of Microbial Pathogenesis, with an adjunct appointment in the Department of Microbiology & Immunology. Her research focuses on host-directed therapies for infectious diseases through lipid response analysis during inflammation.

Her educational background includes:

• Postdoctoral Fellowship (2015-2016) at the University of Maryland, Baltimore under Dr. David Goodlett
• PhD in Molecular Microbiology & Immunology (2015) from the University of Maryland, Baltimore under Dr. Robert Ernst
• BS in Analytical Biochemistry (2004) from Eastern Michigan University

Dr. Scott's research centers on lipid-driven inflammatory mechanisms in infectious and sterile pathologies. Using cutting-edge mass spectrometry imaging, her lab maps lipidomic and metabolomic dynamics at the host-pathogen interface to identify therapeutic targets. Key emphases include:

• Lipid-mediated pathogenesis in TLR4-stealth infections (e.g., Francisella)
• Development of 3D imaging techniques for pulmonary infection models
• Application of lipid modulation in neurodegeneration linked to sterile inflammation

Her 2016-2019 publications reveal a cohesive trajectory in mass spectrometry imaging innovation, specifically advancing simultaneous visualization of host-pathogen lipid interactions and structural lipid modifications affecting immune responses. This work establishes lipids as central mediators in infection pathogenesis and sterile inflammatory conditions.

No scientific awards are highlighted in the provided documentation.

While specific advisees and grant details aren't documented, her laboratory actively develops host-directed therapeutic strategies using bespoke lipids across pulmonary infection and neurodegeneration models, indicating ongoing research funding and mentorship activities.

Her laboratory integrates lipidomic/metabolomic mapping with advanced imaging to decode disease mechanisms, currently operating across multiple experimental systems including Francisella infection models, sterile inflammation platforms, and neurodegeneration-linked immune response assays.