معرفی
Alison Gurney is a Professor of Pharmacology at the University of Manchester. Her research focuses on ion channels regulating pulmonary vascular tone, particularly in the context of pulmonary hypertension. She investigates mechanisms controlling pulmonary artery smooth muscle cell function using interdisciplinary techniques like electrophysiology, calcium imaging, and molecular biology.
Her work contributes to understanding ion channel roles in diseases such as pulmonary hypertension and has identified novel drug targets. She has co-led projects on congenital bladder diseases and collaborated on studies involving gene therapy and neurovascular coupling.
Research interests include KATP channels, KCNQ potassium channels, mitochondrial calcium signaling, and store-operated Ca2+ channels. Her findings have advanced knowledge of oxygen-sensing mechanisms and pharmacological interventions for vascular diseases.
Prominent collaborations involve studies on bladder pathophysiology in mutant mouse models and the role of LRIG2 in urinary tract disorders. She has published extensively on ion channel function and vascular biology, with recent work exploring neurovascular coupling techniques and TRPV4-mediated vasodilation.
Alison has supervised 11 research projects and contributed to grants investigating congenital bladder diseases. Her lab integrates pharmacology, physiology, and molecular biology to address cardiovascular and pulmonary health challenges aligned with UN Sustainable Development Goals.
