Alicia Little

Alicia Little, MD, PhD, is an Assistant Professor of Dermatology at Yale School of Medicine (Yale University) and Director of the Yale Vulvar Dermatology Clinic. She leads interdisciplinary management of vulvar dermatological conditions and maintains clinical expertise in autoimmune/inflammatory skin diseases including cutaneous lupus, dermatomyositis, lichen sclerosus, psoriasis, and atopic dermatitis.

Her education includes:

• Undergraduate: Amherst College (Chemistry & Neuroscience)
• Medical School: Yale University School of Medicine
• Research Fellowship: Immunobiology, Yale University
• Internship: Yale-New Haven Hospital (Internal Medicine)

Dr. Little's research focuses on immunopathological mechanisms in autoimmune skin diseases, particularly T-cell mediated processes in cutaneous lupus. She investigates hypoxia-inducible factors in disease pathogenesis and develops targeted therapies. Recent work explores comorbidities in lichen sclerosus and dermatological manifestations of COVID-19 infections/vaccines.

Her publications demonstrate consistent focus on: autoimmune dermatoses (especially lupus and lichen sclerosus), therapeutic innovation, epidemiological patterns, and COVID-19 skin manifestations. Article keywords frequently involve immunodermatology, pathogenesis, and clinical-translational research.

Dr. Little directs the Vulvar Dermatology Clinic and collaborates with the Craft Lab and Autoimmune Skin Disease Program. She serves on the Janeway Society and has received research grants from the Colton Center for Autoimmunity.