Alice Spadea

Alice Spadea is an Honorary Research Associate in the Department of Pharmacy at the University of Manchester's Faculty of Biology, Medicine and Health. She works as a NoWCADD Postdoctoral Researcher with expertise in the characterization, in-vitro and in-vivo evaluation of nanoparticulate systems. Her research spans biological models including multicellular spheroids with projects focused on promoting intracellular delivery of nanoparticles.

Spadea's research interests center on nanomedicine and drug delivery systems, particularly for cancer treatment applications. She employs advanced techniques including Ellipsometry to study interactions between nanosystems and lipid monolayers, and Raman and Infrared spectroscopy to analyze cell responses to nanoparticle treatments. Her work contributes to UN Sustainable Development Goals related to health and well-being.

Her publication record demonstrates a clear trajectory in nanoparticle-based cancer therapies, with recent work focusing on hyaluronic acid-displaying nanoparticles for pancreatic cancer treatment, lipid nanoparticle interactions with endosomal membranes, and microfluidic-assisted preparation of targeted nanoparticles. The research shows increasing sophistication in targeting mechanisms and delivery systems for cancer therapeutics.

Spadea is affiliated with the Christabel Pankhurst Institute at the University of Manchester, which focuses on gender equality and women's rights research. Her fingerprint analysis shows active contributions in areas including CD44 immunology (100%), malignant neoplasms (72%), internalization (60%), cancer cell lines (59%), and nanoparticle research (50%).