Alfredo Molinolo

Alfredo Molinolo is an Adjunct Professor in the Department of Pathology at the Vc-health Sciences-schools, University of California, San Diego. His research leverages molecular pathology to investigate oncogenic signaling, therapeutic vulnerabilities, and translational applications in diverse cancers.

Research interests center on:

• Cancer biology: Mechanisms of tumor progression, metastasis, and therapy resistance.
• Molecular oncology: Dysregulated pathways (e.g., Hippo/YAP, mTOR, FAK) in head/neck, breast, and prostate cancers.
• Translational strategies: High-throughput drug screening, biomarker discovery, and clinical trial design.

Recent publications (2023–2025) emphasize: single-cell genomics, CRISPR screens, and phase 1 trials. Trends include targeting metabolic dependencies (glutamine metabolism, ferroptosis), kinase signaling vulnerabilities (PKC-RhoA), and immune-microenvironment interactions.