Alexis Demonbreun

Alexis Demonbreun is a postdoctoral researcher at the University of Chicago, Department of Medicine, specializing in muscular dystrophy and SARS-CoV-2 immunology. Their work bridges cell biology, physiology, and public health with a focus on membrane repair mechanisms and antibody response dynamics.

• Institution: University of Chicago
• Department: Medicine

Research Interests

• Primary focus on muscular dystrophy and cardiomyopathy, including genetic modifiers (e.g., annexin A6, LTBP4) and therapeutic strategies like biologics and glucocorticoids.
• Secondary interests in SARS-CoV-2 epidemiology, antibody durability, and health disparities in pandemic outcomes.
• Methodologies include mouse models, human clinical studies, and bioimaging (MRI, immunofluorescence).

Article Trends: Recent publications (2022–2025) highlight anti-LTBP4 biologics, convalescent immunity, and muscle repair pathways. Over half of their work involves collaborations with co-PIs like Elizabeth McNally and Timothy McDade.

Grants & Collaborations: Leading NIH-funded projects (R21TR005472, UH3NS127383) on neuromuscular therapies, and co-investigating NIH grants (R01CA294703, R01HL167813) on cancer cachexia and cardiac fibrosis.