معرفی
Dr. Alexandre Prat is a Full Professor in the Department of Neuroscience at the University of Montreal Faculty of Medicine and holds the Canada Research Chair in Multiple Sclerosis. He serves as Associate Director of Development at the CRCHUM (CHUM Research Centre) and directs the Neuroimmunology Laboratory, focusing on blood-brain barrier (BBB) dysfunction in multiple sclerosis (MS) and other neuroinflammatory disorders. His work has led to the development of an MCAM-targeting drug in Phase II trials, and he trains the next generation of researchers through mentorship and institutional capacity-building.
- University of Montreal, Faculty of Medicine (since 2003)
- CRCHUM (CHUM Research Centre)
- Neuroimmunology Laboratory
- Canada Research Chair in Multiple Sclerosis
- Senior Researcher, FRQ-S
Research Focus: Neuroimmunology and blood-brain barrier (BBB) mechanisms in multiple sclerosis (MS), including:
- BBB permeability and immune cell migration
- Role of adhesion molecules (MCAM, ALCAM, DICAM)
- Astrocyte-microglia interactions
- TH17 lymphocyte pathogenicity
- Neuroinflammatory cytokine pathways
- COVID-19 neurological complications
Scientific Awards:
- Canada Research Chair (Tier 1) in Multiple Sclerosis
- S. Weir Mitchell Award, American Academy of Neurology
- Prix André-Dupont, Quebec Clinical Research Club
- CRCHUM Young Researcher Award
- Royal Society of Canada College of New Scholars inductee (2015)
Training & Grants: Mentored 6 PhD and 13 Master's students. Received 4 CIHR operating grants, 2 CIHR team grants, and 2 Canadian MS Society grants. Key projects include Canadian Progressive Cohort in Multiple Sclerosis and Targeting Novel Adhesion Molecules to Control Neuroinflammation.
