Alexander Zestos

Alexander Zestos is an Assistant Professor in the Department of Chemistry at American University's College of Arts and Sciences. His research focuses on developing advanced electrochemical sensors for neurochemical detection, with applications spanning neuroscience, pharmacology, and drug abuse studies.

Dr. Zestos completed his academic training with a B.S./M.S. in chemistry from the College of William and Mary, followed by a PhD in Chemistry from the University of Virginia. He then pursued postdoctoral research at the University of Michigan, where he further developed his expertise in neurochemical analysis techniques.

His primary research interests center around analytical chemistry approaches to neuroscience problems. Dr. Zestos specializes in using carbon-fiber microelectrodes to detect neurotransmitters and biologically relevant molecules through fast scan cyclic voltammetry. His laboratory develops superior electrochemical sensors using novel nanomaterials and employs liquid chromatography-mass spectrometry to detect neurotransmitters with microdialysis. His work has significant applications in understanding drug abuse mechanisms, neuropharmacology, and neurological disorders.

Dr. Zestos's publication record demonstrates a strong focus on developing and refining electrochemical detection methods for neurotransmitters. His research shows a consistent trajectory from fundamental sensor development to specific applications in neuropharmacology, particularly regarding drug abuse mechanisms. Recent work has expanded into epilepsy research and adipose tissue signaling, showing the versatility of his analytical approaches across different biological systems.

Dr. Zestos actively mentors students at multiple levels including M.S. students, B.S. students, and postbaccalaureate researchers. His laboratory team currently includes several graduate and undergraduate students working on various aspects of electrochemical sensor development and neurochemical analysis. His research appears to be supported by multiple funding sources, though specific grants are not detailed in the available information.

The Zestos Laboratory maintains an active research program focused on four main projects: Development of Carbon Nanotube Microelectrodes for Neurotransmitter Detection, Detection of Neurotransmitter Metabolites using Fast Scan Cyclic Voltammetry, In vivo Neuropharmacology of Amphetamine and Cocaine, and Detection of Dopamine in Zebrafish. These projects reflect the laboratory's commitment to advancing both the technical capabilities of neurochemical detection and its applications to pressing neuroscience questions.