Alexander Pfeifer

Prof. Alexander Pfeifer is a Professor at the University of Bonn, affiliated with the Institute for Pharmacology and Toxicology and serving on the Transdisciplinary Research Area (TRA) - Life and Health Steering Committee. His research focuses on cGMP signaling, G-protein-coupled receptors, and metabolic diseases, particularly obesity. He investigates how these pathways can be manipulated via pharmacological tools and nanoparticles to develop therapies targeting metabolic imbalances and obesity-related conditions.

Key research areas include energy homeostasis, adipocyte function, and the role of signaling molecules like inosine in enhancing energy expenditure. His lab employs advanced techniques such as lentiviral vectors, metabolic cage studies, and transgenic mouse models. Current projects explore therapeutic approaches using viral vectors and nanoparticles to modulate metabolic pathways.

Recent work highlights mechanisms linking obesity to cardiovascular diseases and diabetes, with a focus on adipocyte-macrophage interactions and brown fat activation. Collaborations span translational medicine and nanotechnology, aiming to bridge basic science and clinical applications.