Alexander Arnold

Dr. Alexander "Leggy" Arnold is a Professor and Director of the Milwaukee Institute for Drug Discovery (MIDD) at the University of Wisconsin-Milwaukee. His research focuses on drug discovery targeting nuclear receptors and GABA(A) receptors, particularly for respiratory diseases like asthma.

• Institution: University of Wisconsin-Milwaukee
• Department: Chemistry and Biochemistry
• Role: Professor & Director of MIDD

The Arnold Group develops bioactive probes through interdisciplinary approaches combining organic chemistry, pharmacology, and computational modeling. Key projects include:

• Targeting vitamin D receptor (VDR) coregulator interactions to modulate gene regulation
• Designing tissue-selective GABA(A) receptor ligands for asthma treatment
• Investigating synergistic hormone-independent nuclear receptor signaling strategies

Publications highlight advancements in:

• Structure-activity relationship (SAR) studies for receptor ligands
• Biorenewable solvent applications in chemical synthesis
• Pharmacokinetic and pharmacodynamic profiling of asthma candidates
• Development of first-in-class anti-inflammatory compounds

Research techniques include high-throughput screening, virtual screening pharmacophore modeling, and parallel synthesis approaches. The group has advanced multiple compounds toward clinical evaluation, notably MIDD0301 for asthma treatment.