Alex Mirnezami

Professor Alex Mirnezami is a leading Surgical Oncologist at the University of Southampton's Faculty of Medicine, specializing in complex cancer surgery and translational research. He holds a Professorship in Surgical Oncology and is an active member of the Institute of Developmental Sciences and Clinical Cancer Researchers.

His primary research interests focus on:

• Surgical management of colorectal cancer and pelvic malignancies
• Development of novel techniques for pelvic exenteration and reconstruction
• Investigation of tumor immune microenvironment and immunotherapy applications
• Molecular mechanisms of cancer progression, particularly microRNA pathways

Professor Mirnezami's recent publications reveal a strong emphasis on improving outcomes for patients undergoing complex pelvic surgery, with particular focus on the 'empty pelvis syndrome' - a major postoperative complication. His work combines clinical innovation with molecular research, spanning surgical technique development, immunotherapy applications, and genetic analysis of rare cancers like pseudomyxoma peritonei. His research bridges laboratory findings with clinical applications through organoid models and novel radiotherapy approaches.

Scientific recognition includes:

• The PelvEx Collaborative's core dataset on empty pelvis syndrome (2024)
• Multiple Cancer Research UK-funded projects
• Wessex Medical Research Innovation Grant

He actively supervises PhD candidates including Charles Timothy West (DM Cancer Sciences), securing substantial research funding from Cancer Research UK, Medical Research Council, and industry partners like Integra LifeSciences. His leadership extends to the Cancer Research UK Southampton Centre and collaborative international projects addressing surgical oncology challenges. Professor Mirnezami maintains active clinical involvement while driving innovation in cancer surgery through both technical refinement and molecular investigation.