معرفی
Professor Alan Thomas is a leading academic at Newcastle University specializing in neurodegenerative diseases, particularly dementia subtypes such as Lewy body dementia and Alzheimer’s disease. His research focuses on clinical biomarkers, neuroimaging, and genetic/epigenetic mechanisms underlying neurodegeneration. He leads interdisciplinary studies integrating molecular, imaging, and clinical data to improve diagnostic accuracy and patient outcomes.
- Affiliations: Newcastle University (Professor)
- Key Areas: Dementia progression, biomarker development, neuropsychiatric symptoms in neurodegeneration.
His work emphasizes translational research, including validation of plasma biomarkers, neuroimaging techniques like MRI and PET, and clinical trials (e.g., SYMBAD trial assessing mirtazapine efficacy). He collaborates widely, contributing to international consortia for dementia research.
Research highlights include identifying brain network connectivity patterns in Lewy body dementia and studying molecular mechanisms of α-synuclein aggregation. His group also explores the impact of multimorbidity on dementia neuropathology and the role of epigenetic aging clocks in cortical tissues.