Aladdin Shadyab

Dr. Aladdin Shadyab is an Associate Professor of Public Health, Human Longevity Science, and Medicine at the University of California San Diego, with a joint appointment in the Herbert Wertheim School of Public Health and Human Longevity Science and the Division of Geriatrics, Gerontology, and Palliative Care, Department of Medicine. He is a leading researcher in the epidemiology of aging and longevity with extensive expertise in multi-omics approaches to studying healthy aging.

• PhD in Epidemiology, University of California, San Diego (2016)
• MS in Bioinformatics and Medical Informatics, San Diego State University (2012)
• MPH in Epidemiology, San Diego State University (2010)
• BS in Biochemistry, San Diego State University (2008)

Dr. Shadyab's research focuses on the epidemiology of aging, exceptional longevity, women's health, geroscience, and multi-omics. His seminal work has identified risk factors for major chronic conditions of aging including cardiovascular disease, diabetes, dementia, hip fracture, and cancer, as well as determinants of exceptional longevity and exceptionally healthy aging. He has made significant contributions to identifying aging biomarkers for healthy aging outcomes. His research on longevity has received national and international recognition in prominent media outlets including TIME, Reuters, The Washington Post, and BBC.

Dr. Shadyab's extensive publication record includes over 300 papers in prestigious journals such as JAMA, JAMA Internal Medicine, Alzheimer's & Dementia, and the Journal of the American Geriatrics Society. His work spans multiple domains including genetic epidemiology of longevity, cognitive aging, women's health across the lifespan, dietary influences on aging, and biomarker discovery for age-related conditions. A significant portion of his recent work leverages data from the Women's Health Initiative to examine relationships between biological aging markers, chronic disease risk, and longevity outcomes.

• Journal of Gerontology: Biological Sciences 2025 Associate Editor
• Alzheimer's & Dementia 2025 Top Viewed Articles
• Journal of Gerontology: Medical Sciences 2023 Editor's Choice Manuscript
• Journal of the American Geriatrics Society 2023 Highest Altmetrics Score Award
• Longevity.International 2022 Longevity Leader in Research and Academia
• San Diego State University 2016 Delta Omega Honorary Society in Public Health

As Principal Investigator, Dr. Shadyab leads several multi-million-dollar population-based studies focused on examining the role of biological aging in the etiology of Alzheimer's disease and cognitively healthy longevity. He serves as PI on multiple NIA-funded R01s to identify epigenetic and proteomic biomarkers for mild cognitive impairment, Alzheimer's disease, cognitively healthy longevity, and brain aging. He is also an investigator at the Alzheimer's Disease Cooperative Study, participating in randomized controlled trials for Alzheimer's disease. Dr. Shadyab has received numerous research grants totaling several million dollars to support his work on aging and longevity.

Dr. Shadyab has played a key leadership role in shaping the strategic planning process for the new Herbert Wertheim School of Public Health and Human Longevity Science at UCSD. He serves in several local and national leadership positions, including as Co-Chair of the Women's Health Initiative COVID-19 Scientific Interest Group and on committees for the Gerontological Society of America. He is recognized as one of the world's leaders in longevity research by Longevity.International.