معرفی
Agnes Ferguson is a Research Scientist in the Department of Cell Biology at Yale School of Medicine. She earned her PhD in Neuroscience from the University of Ottawa in 2000. Her research focuses on lysosomal biology and its role in neurodegenerative diseases, including Alzheimer’s, ALS, and Parkinson’s. Key areas include axonal transport of lysosomes, TDP-43 regulation, and mTORC1 signaling pathways. She has collaborated with notable researchers like Pietro De Camilli and published extensively on lysosomal dysfunction in disease mechanisms. Her work bridges cellular biology with translational insights into neurodegenerative disorders.
Education:
- PhD in Neuroscience, University of Ottawa, 2000
- MSc in Physiology, University of Ottawa, 1999
- BSc in Biochemistry-Nutrition, University of Ottawa, 1997
Research Interests: Her studies investigate lysosomal transport defects, neurodegenerative disease pathways, and the role of proteins like JIP3/JIP4 in axonal health. Recent work highlights lysosomal dysfunction in Alzheimer’s amyloid plaques and the impact of genetic mutations on cellular homeostasis.
Publications: Recent studies include investigations into JIP3/JIP4 roles in lysosome transport (2021), TDP-43’s effects on organelle homeostasis (2019), and C9orf72’s lysosomal signaling (2016). These contributions advance understanding of lysosomal biology’s intersection with disease.
Lab & Collaborations: Based at Yale, her lab employs human iPSC-derived neurons and mouse models to study lysosomal mechanisms. Collaborations include studies with Pietro De Camilli on synaptic vesicle dynamics and lysosomal trafficking.
