Adrian Shieh

Adrian Shieh, PhD, is a Teaching Professor at Drexel University's School of Biomedical Engineering, Science and Health Systems. His academic journey includes a BSE in Bioengineering from the University of Pennsylvania (2000), a PhD in Bioengineering from Rice University (2006), and postdoctoral research at École Polytechnique Fédérale de Lausanne (2006-2010). He investigates molecular mechanisms of cancer cell responses to interstitial fluid flow and tumor microenvironment dynamics.

Education:

• BSE, Bioengineering, University of Pennsylvania (2000)
• PhD, Bioengineering, Rice University (2006)
• Post-doctoral Fellow, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne (2006-2010)

Research Focus: Dr. Shieh's work spans mechanobiology, cancer metastasis, and tumor microenvironment. He employs 3D cell culture models to study how interstitial fluid flow influences tumor-fibroblast interactions, signaling pathways (e.g., CXCR4/CXCL12, MEK/ERK), and metastatic behavior. His studies also explore extracellular matrix dynamics and mechanotransduction in cancer progression.

Publication Trends: Recent articles highlight interstitial fluid flow's role in cancer invasion, tumor-fibroblast interactions, and mechanobiological modeling using 3D culture systems. Key areas include hepatocellular carcinoma, ERBB2-positive breast cancer, and biomechanical impacts on chondrocytes.

Awards & Grants:

• Commonwealth Universal Research Enhancement (CURE) Program Grant (2016)