Adam Zlotnick

Adam Zlotnick is a Professor in the Department of Molecular and Cellular Biochemistry at Indiana University Bloomington, with an adjunct appointment. His research focuses on viral capsid assembly mechanisms, particularly in hepatitis B virus (HBV), and the development of antiviral strategies targeting structural proteins. His work integrates computational modeling, biophysical techniques, and biochemical assays to study viral lifecycle processes.

Key research interests include understanding how capsid assembly is modulated by small molecules, nucleic acids, and host factors like importin β. He explores applications in drug discovery, including core assembly modulators (CAMs) and allosteric inhibitors. Zlotnick’s lab also investigates structural dynamics using advanced methods like all-atom molecular dynamics simulations and charge detection mass spectrometry.

His publications since 2020 emphasize HBV capsid stability, assembly pathways, and interactions with antiviral compounds. He has pioneered real-time monitoring of capsid assembly using nanofluidic devices and resistive-pulse sensing. His work bridges basic virology with translational applications in treating chronic viral infections.