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Lisa D WilsbacherView profile

Associate Professor

• Cardiovascular Genetics
• Cardiomyopathy
• Aortopathy
• +5 more

Lisa D Wilsbacher, MD, PhD is an Associate Professor in the Department of Medicine (Cardiology) and Pharmacology at Northwestern University's Feinberg School of Medicine. She serves as Medical Director of the Marfan Syndrome and Related Disorders Clinic and leads the Wilsbacher Lab at the Simpson Querrey Biomedical Research Center. Education: PhD: Northwestern University (2001) MD: Northwestern University Feinberg School of Medicine (2003) Internship/Residency: University of California-San Francisco Medical Center (2004-2007) Cardiology Fellowship: University of California-San Francisco Medical Center (2009) Dr. Wilsbacher's research spans cardiovascular genetics, cardiomyopathy mechanisms, and G protein-coupled receptor signaling. Her lab investigates S1P 1 receptor roles in cardiac development and fibrosis, using mouse models, cell culture, and molecular techniques. Clinical work focuses on genetic cardiomyopathies (dilated, hypertrophic, arrhythmogenic) and aortopathies including Marfan syndrome. Her publications reveal strong emphasis on molecular pathways in heart development and fibrosis, with recent work exploring sex differences in cardiomyopathy outcomes and PAI-1 in cardiovascular aging. Scientific Awards: Outstanding Teacher Award, Northwestern University (2020) Elected Fellow, American Heart Association (2019) Eisenberg Scholar, Feinberg School of Medicine (2017) Rising Star Award, Department of Medicine (2015) As Principal Investigator, she mentors postdoctoral fellows and research technologists while leading clinical trials including the DCM-SHaRe Registry and MYK-491-006 study. Her lab collaborates extensively with Dr. Douglas Vaughan on PAI-1 research and maintains affiliations with the Center for Genetic Medicine and NU CATS. Current projects focus on S1P 1 signaling in cardiac fibrosis and mechanosensory pathways. The Wilsbacher Lab operates within the Simpson Querrey Institute for Epigenetics, utilizing advanced imaging and molecular biology techniques to study cardiomyocyte proliferation and alignment. The team actively recruits graduate students and postdocs interested in cardiac development models.

Regina ArmstrongView profile

Professor

• Traumatic Brain Injury
• Multiple Sclerosis
• Neuroregeneration
• +3 more

Regina Armstrong is Professor and Chair of the Department of Anatomy, Physiology and Genetics at the F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences (USU). She holds secondary appointments in Neuroscience and Molecular and Cell Biology Graduate Programs, and has served as Director of the Center for Neuroscience and Regenerative Medicine (CNRM) from 2008-2017 before becoming Department Chair in 2020. Her educational background includes: Ph.D. in Neurobiology from University of North Carolina, Chapel Hill (1987) B.S. in Neurosciences from University of Rochester (1982) Dr. Armstrong's research focuses on mechanisms of damage and repair in the brain and spinal cord, with particular emphasis on traumatic brain injury and multiple sclerosis. Her laboratory investigates cellular and molecular mechanisms of neuroregeneration, using approaches spanning developmental studies to examining repair after disease or injury. She has extensive expertise in white matter injury in multiple sclerosis models and repetitive closed head injury models of mild traumatic brain injury. Her research team employs diverse methodologies including genetic mouse models, neural stem cell culture, immunohistochemistry, in situ hybridization, fluorescence imaging, magnetic resonance imaging, and behavioral assessments. The team's philosophy integrates data from multiple independent techniques to achieve deeper understanding and improved translational potential. Their work incorporates analysis of human neuropathological specimens to validate animal model findings. Analysis of Dr. Armstrong's recent publications reveals a strong focus on white matter pathology following traumatic brain injury, with particular attention to axonal damage, demyelination, and potential therapeutic interventions. Her work spans basic molecular mechanisms to translational applications, with increasing emphasis on specific signaling pathways like Sonic hedgehog in neural repair processes. There is growing interest in sex differences and chronic effects of repetitive mild traumatic brain injury in her recent work. Dr. Armstrong has received numerous scientific awards: Dean's Faculty Impact Award for Outstanding leadership of CNRM (2017) Prince Mahidol Scholar Fellowship Mentor (2011-2012) Outstanding Biomedical Graduate Educator, USU (2002) John Brinton Hill Award from American Registry of Pathologists (2000) Dr. Armstrong teaches in the first-year medical student nervous system module and graduate courses. Her research has been funded through peer-reviewed awards from NIH, National Multiple Sclerosis Foundation, and Department of Defense. She established the CNRM as a collaborative program between USU, NIH, and Walter Reed National Military Medical Center, focusing on pre-clinical through clinical research to promote recovery from traumatic brain injury and improve service members' psychological health. The CNRM under Dr. Armstrong's leadership emphasizes translational research with practical applications for military medicine. Her laboratory work utilizes collaborations to include analysis of human neuropathological specimens, enhancing the clinical relevance of her research on neural repair mechanisms following traumatic injury.

Thomas P. FlaggView profile

Professor

• Ion Channel Structure & Function
• Cardiac Electrophysiology
• Potassium Channels
• +5 more

Dr. Thomas P. Flagg is a Professor in the Department of Anatomy, Physiology and Genetics at the Uniformed Services University of the Health Sciences (USUHS) School of Medicine in Bethesda, MD. He serves as Co-Module Director for the Foundation in Medicine Module, demonstrating significant leadership in medical education curriculum development. With over two decades of research experience, Dr. Flagg has established himself as a leading expert in cardiac ion channel physiology, particularly focusing on KATP channels and their role in cardiac function and disease. Dr. Flagg's educational background includes: B.S. in Chemical Biology (minor in History) from Stevens Institute of Technology (1989-1993) M.S. in Physiology from University of Maryland, Baltimore (1994-1996) Ph.D. in Physiology from University of Maryland, Baltimore (1996-2001) under mentor Paul A. Welling, M.D. Postdoctoral training at Washington University School of Medicine, St. Louis (2001-2004) with Colin G. Nichols, Ph.D. His research primarily investigates the structure and function of cardiac ion channels, with particular emphasis on KATP channels and their role in cardiac electrophysiology, arrhythmogenesis, and response to metabolic stress. Dr. Flagg's work bridges basic molecular mechanisms with clinical implications, exploring how ion channel dysfunction contributes to cardiac disorders and how therapeutic interventions might target these pathways. His laboratory employs diverse techniques including molecular biology, electrophysiology, transgenic models, and human iPSC-derived cardiomyocytes. Analysis of Dr. Flagg's recent publications (2017-2023) reveals evolving research trajectories. While maintaining his core focus on cardiac ion channels, his work has expanded to include connections with spinal muscular atrophy (SMA), where he investigates how SMN protein deficiency affects cardiac calcium signaling. More recently, his research has branched into nutritional approaches for warfighter health optimization, examining how flavonoids and berry extracts might provide cardioprotective and neuroprotective benefits. This represents a strategic expansion from pure cardiac electrophysiology toward translational applications with military relevance. Dr. Flagg maintains an active research program with consistent publication output across high-impact journals including Circulation, Journal of Molecular and Cellular Cardiology, and Journal of the American Heart Association. His collaborative network spans multiple institutions, with frequent co-authorship with experts in cardiology, electrophysiology, and neuromuscular disorders. While specific grant information isn't provided in the available materials, his sustained research productivity suggests successful funding history from agencies supporting cardiovascular and military-relevant medical research.

• Neuroscience
• Neuroimaging
• Molecular Biology
• +2 more

Philip Alexander Gade Knak serves as a PhD fellow at the Center for Translational Neuromedicine within the Faculty of Health and Medical Sciences at the University of Copenhagen, where he conducts pioneering research on cerebral microcirculation imaging using advanced genetic techniques. His work bridges molecular neuroscience and translational medicine through innovative methodological development. Knak's research program specializes in neuroimaging and cerebrovascular dynamics, with core expertise in CRISPR/Cas9 gene editing systems and fluorescent protein labeling methodologies. He develops viral vector-based approaches for longitudinal visualization of cerebral blood flow in murine models, focusing on technical refinements for both infant and adult brain physiology. His interdisciplinary work integrates molecular biology, optical imaging, and translational neuroscience to address fundamental questions in brain circulation. Analysis of his 2023-2025 publications reveals a cohesive research trajectory centered on viral delivery systems for fluorescent albumin knock-in, enabling unprecedented long-term observation of microcirculation. These methodologies demonstrate significant technical advancement over conventional approaches, with particular innovation in sustaining visualization capacity across developmental stages in mice, holding implications for stroke research and neurodegenerative disease modeling. Scientific Awards: No awards or honors were documented in the available materials. Advising and Grants: Publicly accessible information does not indicate student supervision activities or specific research grant funding. Research Environment: Knak operates within the Center for Translational Neuromedicine at the University of Copenhagen, maintaining active collaborations with prominent neuroscientists including Maiken Nedergaard and Hajime Hirase. His laboratory work employs two-photon microscopy and viral vector technologies within transgenic mouse models to investigate cerebrovascular physiology and glymphatic system function.

Cerrone FosterView profile

Associate Professor

• Cardiovascular Biology
• Endocrinology
• Molecular Medicine
• +5 more

Cerrone Foster serves as an Associate Professor in the Department of Biological Sciences within the School of Science, Engineering, and Math at East Tennessee State University. Her academic career focuses on cardiovascular biology with a specific emphasis on gender differences in heart disease. Dr. Foster's research interests center on the effects of estrogen loss in heart disease and identifying alternative mechanisms to protect the heart from failure in aging and postmenopausal women. Her laboratory employs ovariectomized mouse models and genetic knockout mouse models to investigate molecular signaling pathways, particularly examining the cross-communication between estrogen receptors and G protein coupled receptor signaling. A significant portion of her work focuses on caveolae microdomain structures and their accessory caveolin proteins and their role in estrogen receptor signaling and heart failure. Her recent publications demonstrate a consistent focus on identifying gender-specific therapeutic targets for heart disease, with particular attention to the molecular mechanisms underlying cardiovascular protection in the absence of estrogen. The research spans cardiovascular biology, molecular medicine, endocrinology, and women's health, with implications for developing more effective treatments for postmenopausal women. Dr. Foster teaches BIOL 1110 (Biology for Science Majors I Lecture) and BIOL 4057 (Fundamentals of Molecular Medicine), connecting her classroom instruction with her cutting-edge research in molecular cardiovascular mechanisms. Her laboratory work has significant implications for women's cardiovascular health, as it addresses the specific challenges faced by postmenopausal women who are at increased risk of heart disease following estrogen loss. By identifying alternative cardioprotective pathways, her research could lead to novel therapeutic approaches that don't rely on hormone replacement therapy.

Eran Robert AndrechekView profile

Professor

• Breast Cancer
• Tumor Heterogeneity
• Mammary Gland Development
• +6 more

Eran Robert Andrechek is a Professor in the Department of Physiology at Michigan State University. His research focuses on breast cancer heterogeneity , mammary gland development , and signal transduction pathways in tumor progression. PhD from McMaster University (2003) Postdoctoral training at Duke University Assistant Professor at MSU since 2009 Research Areas include: Computational and genetic modeling of breast cancer progression Role of E2F transcription factors in mammary development and tumorigenesis Investigating metastatic mechanisms in immune-competent mouse models Analysis of signaling pathway signatures for individualized therapy Recent Trends in his publications emphasize Cyclin D1 regulation , organ-specific metastasis , and transcriptional networks in mammary tumors. Grants include funding from: National Institutes of Health (2020-2027) Susan G Komen Foundation (2024-2026) US Department of Defense (2021-2025) McMaster University (1997-2003) He leads the Andrechek Lab , which integrates bioinformatics with genetic models to study breast cancer mechanisms and therapeutic strategies.

Christina M. TerminiView profile

Assistant Professor

• Hematopoietic Stem Cell Biology
• Blood Regeneration
• Leukemia Research
• +4 more

Christina M. Termini is an Assistant Professor in both the Translational Science and Therapeutics Division and the Human Biology Division at Fred Hutchinson Cancer Center. She leads the Termini Lab, which focuses on understanding the basic processes coordinating hematopoietic stem cell function during homeostasis, stress, and disease. Her research integrates cell biology, regenerative medicine, and cancer biology using advanced microscopy, flow cytometry, and transgenic mouse models. Dr. Termini's educational background includes: PhD in Biomedical Sciences (with Certificate in University Science Teaching) from University of New Mexico (2016) MM in Music Performance from University of New Mexico (2015) BA/BS in Music and Biological Sciences from University of Maryland (2011) Her research focuses on how blood stem cells are regulated and how these processes are hijacked during stress and disease. Specifically, she investigates how proteins and glycans synergize to regulate hematopoietic cell fate during homeostasis and in response to stressors like radiation and chemotherapy. Her lab employs transgenic mouse models, in vivo stem cell transplantation assays, patient-derived xenografts, confocal microscopy, super-resolution microscopy, and RNA sequence analysis. Analysis of her 15 most recent publications reveals a consistent focus on hematopoietic stem cell biology, particularly the role of proteoglycans and glycobiology in stem cell regulation. Her work spans from fundamental molecular mechanisms to clinical applications, with increasing attention to laboratory management, mentorship, and diversity, equity, and inclusion in science. Dr. Termini is deeply committed to mentoring and scientific training: Affiliated with University of Washington Molecular & Cellular Biology and Molecular Medicine and Mechanisms of Disease (M3D) Graduate Programs Faculty mentor for Invent at Seattle Children's Postdoctoral Scholars Program Associated with University of Washington Post-Baccalaureate Research Education Program (PREP) Mentor for Fred Hutch Postbaccalaureate Scholar Program and Damon Runyon SPARK Program Her laboratory is supported by funding from NIDDK, NCI, AHA, and V Foundation. The Termini Lab maintains affiliations with multiple scientific communities including the University of Washington Institute for Stem Cell & Regenerative Medicine, Fred Hutch/University of Washington/Seattle Children's Hospital Cancer Consortium, and the Fred Hutch Immunotherapy Integrated Research Center.

Donato SantovitoView profile

Professor

• Atherosclerosis
• Epigenetics
• MicroRNAs
• +5 more

Donato Santovito is a DZHK Professor for Vascular Immunotherapy at the Ludwig-Maximilians University (LMU) of Munich, affiliated with the Institute for Cardiovascular Prevention (IPEK). His research focuses on epigenetic regulatory mechanisms in cardiovascular disease, with particular emphasis on atherosclerosis and its associated immune response. Dr. Santovito's research centers on understanding the molecular mechanisms behind canonical and non-canonical features of microRNA function and trafficking, the interaction of multiple epigenetic regulatory mechanisms, and how they contribute to communication between stromal and immune cells within and beyond the vessel wall. His work combines biophysical and molecular biology methods, sequencing techniques, experiments involving transgenic mouse models in vivo , and ex vivo translational studies to identify molecular mechanisms that can be exploited as therapeutic targets for atherosclerosis and cardiovascular diseases. His investigations particularly focus on non-coding RNAs and histone modifications in atherosclerosis and cardiovascular disease. Dr. Santovito has received several scientific honors, including: Italian Society of Internal Medicine (SIMI), Research Award in Internal Medicine (2013) As leader of the Santovito Lab for Translational Vascular Therapy, he mentors a research team investigating epigenetics and autophagy in atherosclerosis. His lab has secured funding for studies on microRNA functions and their therapeutic potential in cardiovascular disease. Analysis of his publication record reveals a strong focus on translational approaches to cardiovascular therapeutics, with particular emphasis on identifying molecular targets for intervention in atherosclerosis development and progression. The Santovito Lab focuses on translational vascular therapy research, studying the role of epigenetics and autophagy in atherosclerosis and cardiovascular disease. The lab's work aims to identify molecular mechanisms that can be exploited as therapeutic targets or diagnostic/prognostic markers to improve the standard of care for atherosclerosis and cardiovascular diseases, which still account for the first cause of death worldwide.

John M SeubertView profile

Adjunct Associate Professor

• Cardioprotection
• Epoxyeicosatrienoic Acids (EETs)
• Mitochondrial Dynamics
• +4 more

John M Seubert serves as an Adjunct Associate Professor in the Department of Pharmacology at the University of Alberta's Faculty of Pharmacy and Pharmaceutical Sciences. His research program investigates cytochrome P450-derived metabolites of arachidonic acid, particularly epoxyeicosatrienoic acids (EETs), in cardiac protection and mitochondrial regulation. His educational background includes: BSc Biology (Toxicology) and Psychology Minor, Simon Fraser University (1992) MSc Biology - Aquatic Toxicology, Simon Fraser University (1997) PhD Pharmacology and Toxicology, University of Western Ontario (2002) Dr. Seubert's research focuses on two primary areas: (1) The cardioprotective mechanisms of EETs in ischemia-reperfusion injury, utilizing transgenic mouse models with elevated EET levels and cardiomyocyte experiments; (2) EET-mediated regulation of mitochondrial dynamics and energetics in cellular survival pathways. His laboratory employs techniques including murine cardiac injury models, mitochondrial function assays, and lipid mediator analysis. Analysis of his recent publications reveals strong emphasis on translational cardioprotection, with recurring themes in EET pharmacology, mitochondrial integrity during stress, and therapeutic targeting of soluble epoxide hydrolase. His work bridges molecular cardiology with pharmacological intervention strategies. Professional activities include teaching PHARM367 and PHARM566 courses, with laboratory operations based in the Katz Group Centre (Room 2-020M). Current research directions involve sEH inhibition strategies and mitochondrial protection pathways.

• ADHD
• Neuropsychopharmacology
• Behavioral Neuroscience
• +7 more

Dr. Raly James Perez Custodio is a Post-doctoral Researcher in the Aging group of the Ergonomics Department at the Leibniz Research Centre for Working Environment and Human Factors (IfADo) in Dortmund, Germany, focusing on behavioral phenotyping of neurodevelopmental and neuropsychiatric disorders using rodent models. His academic credentials include: Ph.D. in Pharmacy (Pharmacology), Sahmyook University, Seoul (2021) M.Sc. in Pharmacy (Pharmacology), Sahmyook University (2018) M.A. in Nursing (Clinical Supervision), University of San Carlos, Philippines (2015) B.Sc. in Nursing, Colegio de Sta. Lourdes of Leyte Foundation, Philippines (2013) His research centers on ADHD mechanisms through proteomic analysis of transgenic mouse models, particularly investigating THRSP gene involvement in inattentive subtypes. He also examines addiction pathways related to cannabinoids and stimulants, depression models using NMDA receptor antagonists, and diet-cognition interactions . His methodological approach integrates behavioral phenotyping with molecular analysis of neurotransmitter systems and signaling pathways like Wnt. Publication analysis (2023-2025) reveals three dominant research streams: 1) Molecular characterization of ADHD subtypes via proteomics, 2) Neuropharmacological evaluation of psychoactive compounds' abuse potential and therapeutic applications, and 3) Environmental impacts (diet, circadian disruption) on cognitive function. These intersect at the neuroscience-pharmacology interface with strong translational relevance to psychiatric treatment. As part of IfADo's Aging networking group, Dr. Custodio contributes to interdisciplinary projects on age-related cognitive changes within the Ergonomics Department's framework, collaborating with Prof. Edmund Wascher's team and international partners in South Korea.

Joseph TranquilloView profile

Professor

• Engineering Education
• Computational Electrophysiology
• Engineering Design Methodology
• +2 more

Joseph Tranquillo serves as Associate Provost for Transformative Teaching & Learning and Professor of Biomedical Engineering at Bucknell University, with additional roles as international visiting faculty at Universidad Catolica de Chile. He previously directed the Teaching & Learning Center and co-directed the Institute for Leadership in Technology & Management while co-founding the Bucknell Innovation Group and KEEN Winter Interdisciplinary Design Experience. His educational background includes a B.S. from Trinity College (1997) and Ph.D. from Duke University (2004), supplemented by visiting scholar positions at the University of Utah's Scientific Computing and Imaging Institute and Stanford Technology Ventures Program. Tranquillo's research spans Engineering Education (evidence-based teaching practices and learning environments), Computational Electrophysiology (cardiac electrical activity modeling), Engineering Design Methodology , Entrepreneurship and Innovation , and the integration of Engineering and the Arts . His work emphasizes interdisciplinary approaches to complex systems and pedagogical innovation. Recent publications reveal a strategic shift from computational cardiac modeling toward educational innovation, with contemporary work focusing on algorithmic thinking pedagogy, product archaeology frameworks, and evidence-based bioengineering education practices. Earlier research established foundational contributions to cardiac electrophysiology modeling and transgenic validation. His distinguished honors include: National Academy of Engineering Frontiers of Engineering Education Awardee ASEE Biomedical Engineering National Teaching Award ASEE Theo Pilkington Outstanding Educator Award American Society for Engineering Education Fellow American Institute for Medical and Biological Engineering Fellow NSF Pathways to Innovation Faculty Fellow IEEE Senior Member status Tranquillo has secured major funding from NASA, NIH, NSF, Kern Family Foundation, VentureWell Foundation, Degenstein Foundation, and the US Department of Defense. All research is conducted exclusively with undergraduate students, resulting in media features on Discovery Channel, TEDx, and CNN Health. He has delivered teaching workshops across Finland, Chile, Argentina, Uruguay, and the UK. He leads the Bucknell Innovation Group and KEEN Winter Interdisciplinary Design Experience while maintaining active roles in ASEE leadership and international engineering education collaborations through the Indo-US Collaboration for Engineering Education board.

Michael CarrollView profile

Professor

• Immunology
• Autoimmunity
• Neuroimmunology
• +3 more

Michael Carroll is a Professor of Pediatrics at Harvard Medical School and Senior Investigator in the Program in Cellular and Molecular Medicine at Boston Children's Hospital. With a distinguished career spanning over three decades since his appointment as Assistant Professor in 1985, Dr. Carroll has established himself as a leading expert in immunology, particularly in B cell biology, autoimmunity, and neuroimmunology. His laboratory employs cutting-edge techniques including transgenic mouse models, intravital imaging, scRNA-seq, and CRISPR-Cas9 gene editing to investigate fundamental immunological processes. Dr. Carroll's research focuses on two major interconnected areas: the regulation of autoreactive germinal centers in autoimmune diseases like systemic lupus erythematosus (SLE), and the role of the complement system in neuropsychiatric disorders including schizophrenia. His groundbreaking work demonstrated how the complement component C4 influences synaptic pruning in the brain, providing a mechanistic link between immune function and neuropsychiatric disease. His publication record demonstrates consistent productivity with numerous high-impact papers in top journals including Nature, Nature Neuroscience, and Science Immunology, with recent work continuing through 2025. His research has revealed how self-reactive B cells escape tolerance mechanisms, how epitope spreading occurs in autoimmunity, and how peripheral immune activation can affect brain function. American Arthritis Foundation Fellow and Investigator Pew Scholar award recipient 2016 Research Award by National Alliance for Mental Health Dr. Carroll previously served as Director of the Harvard Graduate Program in Immunology from 2005-2016, mentoring numerous students and postdocs who have gone on to successful careers in immunology. His laboratory currently includes multiple postdoctoral fellows, graduate students, and technicians working on projects related to B cell tolerance, germinal center biology, and neuroimmunology. His work has significant therapeutic implications for both autoimmune diseases and neuropsychiatric disorders, particularly in understanding how complement-targeted therapies might benefit patients with these conditions.

• Skeletal Development
• Bone Metastasis of Cancer Cells
• Molecular Mechanisms of Bone Formation
• +5 more

Jane B Lian serves as an Adjunct Professor in the Department of Orthopedics and Physical Rehabilitation at UMass Chan Medical School, with additional affiliations in Bioinformatics and Integrative Biology. Her research spans skeletal biology, cancer metastasis to bone, and epigenetic regulation of bone formation. Education: BS in Chemistry from Fordham University MS in Biophysics from University of Rochester PhD in Biochemistry from Boston University School of Medicine Dr. Lian's research focuses on the molecular mechanisms regulating skeletal development and metastasis of cancer cells to bone. Her laboratory investigates combinatorial control mechanisms for skeletal development, tissue-specific gene regulatory mechanisms, cancer cell biology in the bone microenvironment, and gene therapy for skeletal diseases. Current investigations include how bone morphogenetic protein (BMP) family, Wnt signaling pathway, and Hox homeodomain factors integrate for tissue-specific gene expression, with particular focus on the transcription factor Runx2/Cbfa1 essential for skeletal development. Analysis of her recent publications (2023-2025) reveals a strong emphasis on epigenetic regulation in bone biology, particularly the role of long non-coding RNAs in osteoblast differentiation and stem cell fate determination. Her work increasingly connects skeletal development pathways with cancer metastasis mechanisms, especially how Runx2 activity influences breast and prostate cancer progression in bone. Emerging research directions include microRNA approaches to cancer risk assessment and the role of chromatin organization in cell cycle regulation during cancer progression. Dr. Lian mentors graduate and MD/PhD students through research projects investigating molecular mechanisms of bone formation and cancer metastasis. Her laboratory employs diverse approaches including cell culture models for chondrocyte and osteoblast differentiation, gene regulation studies, and characterization of mouse phenotypes. Current grant-supported work focuses on understanding the epigenetic regulation of bone formation and developing targeted therapies for skeletal diseases and bone metastasis. Her research team operates at the intersection of skeletal biology and cancer research, with particular expertise in the Runx2 transcription factor network. The laboratory utilizes advanced techniques including chromatin immunoprecipitation, enforced expression and siRNA knockdown studies, transgenic mouse models, and in vivo imaging of tumor growth. Current projects aim to develop tissue engineering approaches for skeletal diseases and identify novel therapeutic targets for preventing cancer metastasis to bone.

• Neuroscience
• Neurophysiology
• Systems Neuroscience
• +3 more

Daisuke Shimaoka is a Research Fellow at Monash University's Physiology department. His research focuses on neural circuit dynamics, visual processing, and brain-wide activity patterns. He leads and collaborates on projects including an NHMRC-funded initiative developing Digital Mirror Device (DMD) technology for neural circuit manipulation, and a study on brain-wide activity patterns' simplicity. His work integrates neurophysiological techniques with computational modeling. Active Projects: 2023-2025 (DMD system development) and 2025-2029 (brain connectivity analysis) Key research areas include: Functional and anatomical connectomics Arousal state effects on sensory processing Neural mechanisms of consciousness and sleep-wake transitions Optical imaging techniques for behaving animals Major contributions include defining visual cortex organization in mice and primates, elucidating bilateral neural activity impacts, and developing genetic tools for neural circuit interrogation. His work has been cited over 300 times across 11 publications.

Anthony PurcellView profile

Research Professor

• Immunology
• Proteomics
• Autoimmunity
• +4 more

Anthony Purcell is a Research Professor in Biochemistry & Molecular Biology at Monash University, affiliated with the Monash Biomedicine Discovery Institute. He holds a Visiting Professorship at the University of Southampton (2016–2019) and serves as Councillor of the Human Proteome Organization (2017–2023). His research focuses on quantitative proteomics, immune response targets, and host-pathogen interactions. Key areas include cancer immunology, autoimmunity (e.g., diabetes, psoriasis), antigen processing, vaccine design, and bioinformatics. Purcell has led or contributed to 54 research projects and over 336 publications, including high-impact journals like Nature and Nature Immunology. He is an editorial board member for Molecular & Cellular Proteomics and Molecular Immunology. Notable contributions include developing immunopeptidomics tools and identifying novel therapeutic targets in cancer and autoimmune diseases. His lab collaborates globally and contributes to UN Sustainable Development Goals. Research Interests Quantitative proteomics of complex biological samples Immunopeptidome analysis for antigen discovery Autoimmunity mechanisms (e.g., type 1 diabetes, psoriasis) Cancer immunotherapy targets Vaccine design (influenza, cancer) Recent Research Output Recent studies highlight advances in immunopeptidomics, including identification of tumor antigens, psoriasis triggers, and influenza epitopes. Collaborations span structural biology, bioinformatics, and clinical translation. Grants & Collaborations Active projects include non-canonical influenza immunity, type 1 diabetes epitopes, breast cancer vaccine targets, and psoriasis antigen triggers. Purcell’s work has attracted global attention, including media coverage of superbug research funded by A$9.8 million grants. Labs & Teams Leads the Purcell Lab at Monash, focusing on integrating proteomics with immunology and structural biology to address immune-related questions.