Tissue Microarray Technology Professors and Supervisors

Xiaojian ShaoView profile

Adjunct Professor

University of OttawaCanada

Dr. Xiaojian Shao is an Adjunct Professor at the Department of Biochemistry, Microbiology and Immunology of the Faculty of Medicine, University of Ottawa, and a Research Officer at the Digital Technologies Research Center, National Research Council of Canada. His research focuses on Bioinformatics, Computational Biology, and Epigenomics , with expertise in Single Cell Genomics, Machine Learning, and Cell/Gene Therapy. University: University of Ottawa School: Faculty of Medicine Department: Department of Biochemistry, Microbiology and Immunology Academic Rank: Adjunct Professor Other Role: Research Officer, NRC Digital Technologies Research Center Emails: xiaojian.shao@nrc-cnrc.gc.ca, xshao2@uOttawa.ca Dr. Shao’s research spans epigenetic mechanisms in diseases, environmental impacts on methylomes, and computational methods for genomic analysis. His work includes: Cross-sectional studies on DDT/DDE exposure and sperm epigenome DNAmethylation changes in rheumatoid arthritis and dementia Development of software tools like DMEAS for methylation analysis Investigations into growth hormone effects and folate metabolism Single-cell sequencing applications in COPD and cancer Recent publications highlight trends in environmental epigenetics, disease biomarkers, and computational methods , including cross-continental studies on toxicology and neurodegenerative diseases. Dr. Shao collaborates with institutions such as the National Research Council of Canada and contributes to journals like Environmental Health Perspectives and Communications Biology .

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Adrian RangaView profile

Associate Professor

KU LeuvenBelgium

Adrian Ranga is an Associate Professor at the Department of Mechanical Engineering within KU Leuven's Faculty of Engineering Science . He leads research at the BioMechanics (BMe) section, with affiliations to multiple institutes including the KU Leuven Institute of Physics-based Modeling for In Silico Health , Brain Institute , and Institute for Single Cell Omics . His work focuses on organoid engineering , mechanical force manipulation , and vascularization technologies using microfluidic devices . Key Research Areas: Vascular and neural organoid development Microfluidic cell culture systems Mechanotransduction mechanisms Stem cell-based tissue engineering Recent Publications (2025–2024) demonstrate expertise in 3D bioprinting , force-mediated angiogenesis , and comparative neurodevelopment across species. His patent applications include discrete cell culture microenvironments and photopolymerized devices . Collaborative projects span the Interreg Biomat-on-Chip Consortium and FWO-funded initiatives .

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Stephanie SeidlitsView profile

Assistant Professor

University of California, Los AngelesUnited States

Stephanie Seidlits is an Assistant Professor in the Department of Bioengineering at UCLA's Samueli School of Engineering. Her research focuses on developing biomaterials for neural repair, particularly hydrogel-based scaffolds and gene delivery systems to promote spinal cord regeneration. Recent publication trends show expertise spanning: Biomaterial design for neural applications Gene therapy delivery mechanisms Spinal cord injury repair strategies Hydrogel optimization for cell differentiation Neurotrophin signaling pathways Scar formation modulation Collaborations include neuroscience researchers at UCLA and other institutions, with publications in journals spanning biomaterials, neuroscience, and biomedical engineering fields.

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Josep ComeronView profile

Professor

University of IowaUnited States

Josep Comeron is a Professor in the Department of Biology at the University of Iowa, College of Liberal Arts and Sciences. His research program investigates genome variation across individuals and species, with a specialized focus on recombination as a fundamental evolutionary parameter in the Drosophila model system. Education PhD, University of Barcelona (Catalonia) Research Focus Professor Comeron employs interdisciplinary methodologies including population genetics, bioinformatics, computer simulations, and next-generation sequencing to study molecular causes and evolutionary consequences of recombination variation. Current NSF-funded research examines mechanistic links between stressful conditions and increased recombination rates in collaboration with Dr. Ana Llopart's lab, leveraging Drosophila's genetic tools to explore genomic and transcriptomic responses. Publication Trends His 15 most recent publications (2024-2012) reveal consistent innovation in recombination modeling, 3D genome architecture analysis, and telomere dynamics. Key themes include predictive recombination rate mapping in Drosophila, alternative telomere-lengthening pathways, and the impact of background selection on genomic diversity, demonstrating integration of computational and experimental approaches. Advising and Funding Actively recruiting graduate and master's students for NSF-supported projects, Comeron mentors through the Department of Biology's Integrated Biology (iBio) program and the Interdisciplinary Graduate Program in Genetics. His lab provides training in genomics, population genetics, bioinformatics, and theoretical modeling within collaborative research frameworks. Research Facilities The Comeron Lab operates from rooms 212/215 in the Biology Building, utilizing university core facilities including the Carver Center for Genomics and Carver Center for Imaging. His research capitalizes on Drosophila's unparalleled genetic toolkit for genome-wide analyses of recombination and evolutionary processes.

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Zi-Xuan (Zoe) WangView profile

Associate Professor

Thomas Jefferson UniversityUnited States

Zi-Xuan (Zoe) Wang serves as Associate Professor in the Department of Pathology & Genomic Medicine at Thomas Jefferson University's College of Life Sciences, concurrently holding leadership positions as Technical Director of Molecular Pathology and Scientific Director of the Pathology Translational Genomics Laboratory she recently established. Her research program pioneers genomic and personalized medicine through advanced molecular technologies. The laboratory specializes in whole genome profiling for microDNA expression, DNA methylation, and copy number variation analysis using microarray platforms, alongside next-generation sequencing (Roche 454 FLEX) for RNA seq, ChIP seq, mutation detection, and bisulfite conversion-based methylation verification. She maintains active collaborations with basic scientists and clinicians to investigate genomic mechanisms underlying human diseases. Dr. Wang's publication record demonstrates translational impact across diverse disease domains including thyroid cancer diagnostics, sarcoma genetics, myeloid neoplasms, pancreatic adenocarcinoma, and immunotherapies for infectious diseases, reflecting her laboratory's broad genomic application capabilities. She directs the Pathology Translational Genomics Laboratory as a central hub for genomic research integration into clinical pathology practice, driving innovation in molecular diagnostics and personalized treatment approaches.

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Ana Rita GrossoView profile

Assistant Professor

NOVA University LisbonPortugal

Ana Rita Grosso is an Assistant Professor at NOVA University Lisbon's Faculty of Science and Technology. She leads the Computational Multi-Omics Lab (CompMultOmics@UCIBIO), focusing on understanding genome biology and its disease implications through computational approaches. Her research integrates multi-omics data (genomics, proteomics, transcriptomics) with clinical information to study: Cancer evolution and intra-tumor heterogeneity Epigenetic regulation in disease Transcriptional readthrough and pseudogene detection Metabolic control of cellular states Immune evasion mechanisms She develops statistical methods for high-throughput sequencing, microarray, and proteomic data analysis. Recent publications (2015-2022) demonstrate strong focus on: Pan-cancer analyses of genetic/epigenetic heterogeneity Innovative model systems (zebrafish xenografts) Transcriptional regulation mechanisms Computational method development Renal and colorectal cancer biology Work appears in high-impact journals including Nature Cell Biology, Cell, and Nature Communications. She actively trains MSc/PhD students and teaches computational biology courses to address bioinformatics skill gaps in research. Her lab promotes seminars for researchers across career stages.

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Lance LiottaView profile

Professor

George Mason UniversityUnited States

Lance Liotta is a Professor and Co-Director of the Center for Applied Proteomics and Molecular Medicine (CAPMM) at George Mason University's School of Systems Biology, where he has led transformative research since 2005 after a distinguished NIH career spanning roles as Chief of NCI's Laboratory of Pathology and Deputy Director of NIH. His PhD in Biomedical Engineering from Case Western Reserve University established foundational work on cancer metastasis modeling. Current research focuses on proteomics-driven diagnostics and therapeutics, highlighted by inventions like Laser Capture Microdissection (Smithsonian Collection) and Reverse Phase Protein Microarrays. Recent publications (2024-2025) reveal dominant themes in extracellular vesicle biology across cancer and infectious diseases, with strong emphasis on mitophagy mechanisms, Lyme/Chagas disease diagnostics, and machine learning integration for biomarker discovery in breast/gastric cancers. The work bridges molecular profiling with clinical applications through CAPMM's technology pipeline. Major scientific recognition includes: Outstanding Virginia Faculty Award (2015) Flemming Award for Cancer Research Warner-Lambert Parke Davis Award Surgeon General’s Medallion ISI Highly Cited Investigator status With over 690 publications and 100+ patents, Liotta has secured extensive grant funding enabling clinical translation through spin-offs Theranostics Health and Ceres Nanosciences. His mentorship at CAPMM has cultivated numerous researchers, though specific advisees aren't documented in source materials. CAPMM operates as a multidisciplinary engine advancing proteomic technologies from basic discovery (e.g., secretory mitophagy pathways) to clinical implementation, with active trials targeting early cancer detection and personalized therapy through molecular profiling of tissue, cells, and biofluids.

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Joydeep ChaudhuriView profile

Professor

Central Michigan UniversityUnited States

Dr. Joydeep Chaudhuri is a Professor at the College of Medicine in Mt. Pleasant, Michigan, with over 25 years of international teaching experience across India, Malaysia, Finland, Canada, and the United States. He instructs medical, dental, physician assistant, physical therapy, and occupational therapy students in anatomy and medical education disciplines. His educational background includes: MS in Anatomy and Cell Biology from All India Institute of Medical Sciences, New Delhi M.B.B.S. from Regional Medical College, Imphal Dr. Chaudhuri's research spans two distinct phases: early neuroscience investigations of Fetal Alcohol Syndrome and Alzheimer's disease using animal models, and current pioneering work in medical education. His contemporary scholarship focuses on enhancing intrinsic motivation in medical students and mitigating psychological distress during cadaveric dissection. This research bridges educational theory, cognitive psychology, and anatomical sciences, producing practical interventions that transform anatomy pedagogy. Analysis of his 15 most recent publications reveals a strategic evolution toward medical education scholarship, with 2020-2022 works demonstrating rigorous evaluation of prelaboratory assignments, drawing exercises, and mental preparation protocols. These studies consistently show improved academic performance, increased engagement, and reduced anxiety among students, establishing him as a significant contributor to evidence-based anatomy education. Dr. Chaudhuri actively mentors medical and graduate students in educational research. His international collaborations across five countries provide unique cross-cultural perspectives on medical training. While no specific awards are documented, his sustained publication record in top anatomy education journals reflects scholarly impact. Current work continues to develop innovative frameworks for student motivation and psychological support in anatomical sciences education.

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Matthew I. GibsonView profile

Professor

University of WarwickUnited Kingdom

Professor Matthew I. Gibson holds a joint appointment between the University of Warwick's Department of Chemistry and Warwick Medical School . A Royal Society Industry Research Fellow and ERC Consolidator Grant recipient, he leads the iCASE Scheme at the MRC-funded Doctoral Training Center and co-founded CryoLogyx Ltd. Education MChem, 1st Class (2003), University of Durham PhD in Macromolecular Chemistry (2007), University of Durham Postdoc, EPFL (2007-2009) Research focuses on glycosciences and biomaterials for cryopreservation, infection detection, and cell surface modification. His group develops glycosylated nanomaterials and ice recrystallization inhibitors with applications in cell therapy storage and diagnostics. Current projects include the EU-funded Nanocarb and ICE_PACK (ERC) initiatives. Selected Publications address glycomaterial selectivity (2021, JACS Au), polymer-enhanced ice control (2021, JACS), cyclic ice-binding peptides (2021, Nature), and glycosylated nanoparticle diagnostics (2022, Chemical Society Reviews). Key keywords: Glycobiology, Biomimetic Materials, Polymer Nanotechnology, Antifreeze Proteins Scientific Awards include the McBain Medal , RSC Emerging Technology Prize , and multiple Young Investigator recognitions from Biomacromolecules and MacroGroupUK. Teaching includes modules on polymers, glycosciences, and living polymerization. He (co-)supervises 15+ PhD students in glyconanomaterials, cryoprotectants, and cell engineering projects.

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Maria Angelica Alliende RodriguezView profile

Associate Professor

University of ChileChile

Maria Angelica Alliende Rodriguez is an Associate Professor at the Institute of Nutrition and Food Technology within the University of Chile's Faculty of Medicine. Her research focuses on genetic disorders, particularly fragile X syndrome, chromosome 15 imprinting disorders, and neurodevelopmental abnormalities, with extensive publications in molecular genetics, clinical diagnostics, and public health applications. Education : Master in Biological Sciences (1991), Medical Technologist (1975), both from the University of Chile. Her work spans molecular techniques for fragile X syndrome diagnosis, newborn screening workflows, and clinical-genetic correlations in neurodevelopmental disorders. She has contributed to understanding FMR1 expression, mosaicism, and autistic features in genetic conditions. Key collaborations include studies on genetic screening, subtelomeric assays, and clinical management of Prader-Willi/Angelman syndromes. Her publications (1991–2023) reflect interdisciplinary research in genetics, neuroscience, and public health policy in Chile.

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Peining LiView profile

Professor

Max Planck Institute of Molecular Cell Biology and GeneticsGermany

Dr. Peining Li is a Professor of Genetics at Yale School of Medicine, where she serves as Director of the Cytogenetics Laboratory and Co-Director of the Fellowship in Laboratory Genetics and Genomics. Her primary affiliations include the Department of Genetics, Yale Center for Genomic Health, and Yale Ventures. She leads a research program focused on structural and functional characterization of human chromosome abnormalities using advanced molecular techniques. Her research interests span: Cytogenetics and chromosome aberration analysis Genomic diagnostics using microarray and sequencing technologies Cancer genomics with focus on hepatocellular carcinoma Reproductive genetics including pregnancy loss mechanisms Recent publications demonstrate her work in pediatric genetic diagnostics, NGS concordance studies, stem cell applications, and ring chromosome characterization. Her lab provides clinical services for diverse specimen types including blood, amniotic fluid, and tumor samples.

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Shrikant ManeView profile

Professor

Max Planck Institute of Molecular Cell Biology and GeneticsGermany

Dr. Shrikant Mane is a Professor of Genetics at Yale School of Medicine, where he directs the Yale Center for Genome Analysis (YCGA) Shared Resource and The Keck Biotechnology Resource Laboratory. He has over 25 years of research experience in both academic and private industry settings, with expertise in genomic and proteomic analyses using microarray and high-throughput DNA sequencing technologies. Dr. Mane received his Ph.D. in Cancer Biology in 1985 and completed his postdoctoral training at Johns Hopkins University School of Medicine. He has published over 125 scientific articles and holds 2 patents. His research spans genetics, genomics, DNA sequence analysis, neuroscience, and cancer biology, with a particular focus on Mendelian genomics and disease gene discovery. His laboratory work has provided over 58,000 sequence analyses to 225 Yale and 124 non-Yale principal investigators from 72 national and 16 international institutions. Dr. Mane is one of four Principal Investigators of the Yale Center for Mendelian Genomics, established in 2012 through an $11.2 million grant from NHGRI. His recent publications (2023-2025) demonstrate a strong focus on identifying genetic causes of kidney disorders, congenital heart disease, and neurodevelopmental conditions through large-scale genomic studies published in high-impact journals including Nature, Nature Communications, and PNAS. Notable Achievements: Principal Investigator of the Yale Center for Mendelian Genomics ($11.2 million NHGRI grant) Director of Yale Center for Genome Analysis serving hundreds of researchers worldwide Published over 125 scientific articles in genetics and genomics Extensive experience with genomic technologies spanning 25+ years Dr. Mane's laboratory serves as a major resource for genomic analysis at Yale and beyond, supporting numerous research projects through cutting-edge sequencing and analysis capabilities. His research program bridges technological development with clinical applications, particularly in the area of Mendelian disease gene discovery.

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David RimmView profile

Professor

Max Planck Institute of Molecular Cell Biology and GeneticsGermany

David Rimm is the Anthony N. Brady Professor of Pathology in the Departments of Pathology and Medicine (Oncology) at Yale University School of Medicine. He serves as Director of Yale Pathology Tissue Services and the Lab for Quantitative Diagnostics in Anatomic Pathology. Dr. Rimm is a leading researcher in quantitative pathology with over 500 peer-reviewed publications and an H-index of 120. Dr. Rimm completed his MD-PhD at Johns Hopkins University Medical School followed by a Pathology Residency at Yale and a Cytopathology Fellowship at the Medical College of Virginia. His academic journey has positioned him as a key figure in cancer biomarker research and diagnostic development. Dr. Rimm's research primarily focuses on quantitative pathology and cancer biomarker development. His lab pioneered the AQUA method of quantitative immunofluorescence, published in Nature Medicine in 2002, which has been cited over 875 times. His current work involves developing quantitative methods for predicting response and resistance to targeted and immune-therapy in cancer, with particular focus on breast, lung, and melanoma cancers. His lab utilizes high-plex methods including digital spatial profiling for new biomarker discovery and is actively working on standardization of assays for CLIA labs. Analysis of Dr. Rimm's recent publications (2024-2025) reveals a strong focus on quantitative biomarker development for precision oncology, particularly in breast cancer, lung cancer, and melanoma. His work spans from basic method development (quantitative immunofluorescence, AI-driven assessment) to clinical application (companion diagnostics, HER2 testing, antibody-drug conjugate therapies). The publications demonstrate a consistent theme of translating quantitative pathology methods into clinical practice. Lauren Ackerman Lectureship (2008) Starwood Commitment Award (2004) Dr. Rimm's research is supported by grants from the NIH, Breast Cancer Research Foundation (BCRF), and sponsored research agreements from biopharma companies. His lab actively collaborates with industry partners to translate research findings into clinical applications. With over 500 publications and 8 patents, his work has significant impact in the field of quantitative pathology and cancer diagnostics. Dr. Rimm leads the Rimm Lab for Quantitative Diagnostics in Anatomic Pathology, which focuses on developing innovative quantitative approaches to pathology. The lab's work spans from basic research on quantitative methods to clinical translation of diagnostic assays. The lab utilizes tissue microarray technology, high-plex in situ assessment, and quantitative imaging to predict response to cancer therapies.

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Lars MaegdefesselView profile

Professor

Max Planck Institute for Dynamics and Self-OrganizationGermany

Lars Maegdefessel is a Professor of Molecular Vascular Medicine at the Technical University Munich (TUM), School of Medicine and Health. He leads the Experimental Vascular Medicine unit at Klinikum rechts der Isar and serves as a DZHK Junior Group Leader. His research focuses on the therapeutic and biomarker potential of non-coding RNAs in vascular diseases including atherosclerosis, aortic aneurysm, and related vascular pathologies. Dr. Maegdefessel's research interests center on the role of non-coding RNAs in vascular diseases, with particular focus on the vulnerability of atherosclerotic vascular lesions and the progression and rupture of abdominal aortic aneurysms. His laboratory utilizes unique human biobank materials and various pre-clinical experimental models to investigate novel molecular approaches for combating cardiovascular diseases. His work spans from basic research on microRNAs, long non-coding RNAs, and circular RNAs to translational applications in vascular medicine. Analysis of Dr. Maegdefessel's publication record reveals a strong focus on non-coding RNA mechanisms in vascular pathology, with particular emphasis on atherosclerosis stabilization, aneurysm development, and vascular inflammation. His research has evolved from basic miRNA characterization to sophisticated therapeutic applications including targeted delivery systems and novel biomarker discovery. The publications demonstrate a consistent trajectory toward clinical translation of RNA-based vascular therapeutics. ERC Consolidator Grant (2023) Russel Ross Award from American Heart Association (2023) Heisenberg Professorship of German Research Foundation (2016) Werner Risau Award of American Heart Association (2016) ERC Starting Grant (2015) Prince Daniel Research Award of Swedish Heart and Lung Foundation (2014) Ragnar Söderberg Fellowship in Medicine (2014) Dr. Maegdefessel's research program includes extensive collaboration with international teams and utilizes advanced methodologies including RNA sequencing, microarrays, proteomics, and epigenomic analyses. His laboratory investigates ncRNA function in human vascular tissues and pre-clinical models, with recent work focusing on artery-on-a-chip technology and novel therapeutic delivery systems for vascular applications.

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