Ana Rita Grosso

Ana Rita Grosso is an Assistant Professor at NOVA University Lisbon's Faculty of Science and Technology. She leads the Computational Multi-Omics Lab (CompMultOmics@UCIBIO), focusing on understanding genome biology and its disease implications through computational approaches.

Her research integrates multi-omics data (genomics, proteomics, transcriptomics) with clinical information to study:

• Cancer evolution and intra-tumor heterogeneity
• Epigenetic regulation in disease
• Transcriptional readthrough and pseudogene detection
• Metabolic control of cellular states
• Immune evasion mechanisms

She develops statistical methods for high-throughput sequencing, microarray, and proteomic data analysis.

Recent publications (2015-2022) demonstrate strong focus on:

• Pan-cancer analyses of genetic/epigenetic heterogeneity
• Innovative model systems (zebrafish xenografts)
• Transcriptional regulation mechanisms
• Computational method development
• Renal and colorectal cancer biology

Work appears in high-impact journals including Nature Cell Biology, Cell, and Nature Communications.

She actively trains MSc/PhD students and teaches computational biology courses to address bioinformatics skill gaps in research. Her lab promotes seminars for researchers across career stages.