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Showing 31-45 of 116 supervisors

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Michal GoldbergView profile

Professor

The Hebrew University of JerusalemIsrael

Prof. Michal Goldberg is a Professor in the Department of Genetics at the Hebrew University of Jerusalem. Her research focuses on cancer genetics, DNA damage response mechanisms, and genomic stability. She investigates early events in cancer development, including the roles of cell cycle regulation and DNA repair pathways. Her work has identified novel genes involved in familial breast and ovarian cancers and uncovered therapeutic drugs targeting cancer stem cells. Key research interests include the cellular response to DNA damage, genomic instability, and the interplay between estrogen signaling and cancer. Prof. Goldberg has pioneered studies on Spironolactone, demonstrating its efficacy in inhibiting cancer stem cell growth by impairing DNA repair processes. Her findings have implications for developing targeted cancer therapies. Received the SMS grant (2024) and Rector's Prize for Excellent Researchers (2019). Leads a research group exploring cancer genetics and therapeutic drug discovery. Collaborates with institutions like the Institute of Genetics and Molecular and Cellular Biology (France). Her lab's work bridges basic science and clinical applications, with studies published in journals such as Oncogene , Nucleic Acids Research , and Cell Death & Disease .

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Paul ClarkeView profile

Professor

Griffith UniversityAustralia

Professor Paul Clarke (He/Him) is the Executive Director of the Institute for Biomedicine and Glycomics at Griffith University. His research focuses on the molecular mechanisms governing cell division and cell death, with significant implications for cancer diagnosis and treatment. He has held leadership roles at the Frazer Institute and Diamantina Institute at the University of Queensland (2017-2024), served as Associate Dean (Research) at the University of Dundee, and held research fellowships at the University of Manchester and the European Molecular Biology Laboratory. Education : Biochemistry, University of Bristol; PhD in Biochemistry, University of Dundee. Professor Clarke's research explores the intersection of cell cycle regulation, apoptosis, and cancer biology. Current work investigates the role of the innate immune system in cancer cell responses to chemotherapeutic agents that disrupt mitosis. His recent studies include AI-driven nanopore assays for DNA replication stress, phosphorylation mechanisms in spindle assembly, and timed degradation of proteins governing cell survival during mitotic arrest. Scientific trends in his publications emphasize molecular oncology , mitotic signaling , and apoptotic regulation . His work bridges structural biology (e.g., nuclear envelope assembly) and translational applications (e.g., cancer diagnostics).

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Andrea MusacchioView profile

Professor

Max Planck Institute of Molecular PhysiologyGermany

Andrea Musacchio is Director of the Department of Mechanistic Cell Biology at the Max Planck Institute for Molecular Physiology in Dortmund, Germany, and Honorary Full Professor at the University of Duisburg-Essen. Born in Rome in 1964, he holds a Biology degree from Tor Vergata University (summa cum laude) and a PhD in Biochemistry from EMBL/University of Heidelberg. His career includes postdoctoral research at Harvard Medical School and faculty positions at the European Institute of Oncology in Milan. Musacchio's research focuses on the molecular mechanisms of cell division, with emphasis on kinetochore assembly, centromere organization, and mitotic spindle regulation. His lab combines biochemical reconstitution, structural biology (cryo-EM), and cell biology approaches to study protein complexes driving chromosome segregation. His publications demonstrate consistent focus on mitotic regulation mechanisms, with recent work emphasizing structural characterization of kinetochore subcomplexes (CCAN, RZZ), centromere licensing, and checkpoint signaling. Key themes include protein-protein interactions, enzyme kinetics in cell cycle control, and epigenetic maintenance of centromeres. Awards & Grants: Gottfried Wilhelm Leibniz-Preis 2020 (Germany's highest scientific honor) ERC Advanced Grants (2009, 2015) ERC Synergy Grant (2021) EMBO Membership (2009) Chiara D’Onofrio Prize (2006) Multiple prestigious fellowships including HFSP and American Cancer Society As department director, he leads a multidisciplinary team investigating mechanistic cell biology using advanced biophysical and biochemical methods. His group maintains collaborations with structural biologists, chemists, and cell biologists worldwide.

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Jakob NilssonView profile

Professor

University of CopenhagenDenmark

Jakob Nilsson is a Professor at the Novo Nordisk Foundation Center for Protein Research (CPR) within the Faculty of Health and Medical Sciences at the University of Copenhagen, a position he has held since 2016. He leads the Nilsson Group, which focuses on understanding the molecular mechanisms of cell division, particularly mitosis and chromosome segregation. Education: PhD in Molecular Biology from the University of Aarhus (2002) Research Interests: Professor Nilsson's research primarily focuses on the intricate processes of mitosis and cell division. His work investigates how cells accurately segregate their chromosomes during cell division, with particular emphasis on the spindle assembly checkpoint, kinetochore biology, and the regulation of protein phosphorylation/dephosphorylation during mitosis. His laboratory employs advanced techniques including live cell microscopy, structural biology approaches, and biochemical assays to unravel the molecular mechanisms that ensure faithful chromosome transmission from one cell generation to the next. Research Trends: Analysis of Professor Nilsson's recent publications reveals a consistent focus on the molecular mechanisms of mitosis, particularly the role of protein phosphatases in regulating chromosome segregation. His work has made significant contributions to understanding how the Bub1 kinase, RZZ complex, and PP2A/PP4 phosphatases coordinate to ensure accurate chromosome segregation. More recently, his research has expanded to include viral protein interactions, as evidenced by his 2025 publication on SARS-CoV-2 adaptation, suggesting an interdisciplinary approach that connects fundamental cell biology with virology. Scientific Awards: Junior Group Leader Fellowship from the Lundbeck Foundation (1.3 M €) in 2008 Advising and Grants: Professor Nilsson established his independent research group in 2009 through the Lundbeck Foundation Junior Group Leader Fellowship. Since then, he has led a productive research laboratory first at BRIC (2009-2011) and subsequently at the Novo Nordisk Foundation Center for Protein Research (2011-present). His research has resulted in numerous high-impact publications in journals such as Molecular Cell, EMBO Journal, Nature Communications, and Nature Cell Biology, demonstrating sustained funding support for his research program. Laboratory and Collaborations: Professor Nilsson leads the Nilsson Group at the Novo Nordisk Foundation Center for Protein Research, which is part of the University of Copenhagen's Faculty of Health and Medical Sciences. His research involves extensive collaborations both within Denmark and internationally, as evidenced by the diverse authorship on his publications. His work bridges structural biology, cell biology, and biochemistry to address fundamental questions about cell division mechanisms.

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Sabine PetryView profile

Associate Professor

Princeton UniversityUnited States

Sabine Petry is an Associate Professor at the Department of Molecular Biology, Princeton University , with associated appointments in the Department of Chemical and Biological Engineering, Department of Chemistry, and Omenn-Darling Bioengineering Institute. She earned an M.S. in Biochemistry from Goethe University, Frankfurt am Main (2003), and a Ph.D. in Biochemistry from the University of Cambridge (2007). Her research focuses on the molecular architecture and function of the microtubule cytoskeleton , particularly how cells establish specific microtubule arrangements for division, organelle positioning, and force generation. Education: M.S., Biochemistry, Goethe University, Frankfurt am Main, Germany (2003) Ph.D., Biochemistry, University of Cambridge, UK (2007) Her lab employs biophysical methods, X-ray crystallography, cryo-EM, and advanced light microscopy to dissect microtubule nucleation and organization. Recent work highlights include the role of HURP in spindle assembly, branching microtubule nucleation driven by TPX2 condensates, and the interplay between RanGTP gradients and microtubule network architecture. Key publications address spindle pole stabilization, microtubule lattice dynamics, and phase separation mechanisms . Scientific awards include the Packard Fellowship (2014-2019), Pew Scholar (2014-2016), Kimmel Scholar (2014-2016), NIH Pathway to Independence Award (2012-2016), EMBO Long-term Fellowship (2008), FEBS Young Scientist Prize (2007), and Max Perutz Student Prize (2005). She is an advisor to Ph.D. student Ryan MacElroy .

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Christer HöögView profile

Professor

Graz University of TechnologyAustria

Christer Höög is a Professor in Cell and Molecular Biology at the Karolinska Institutet in Stockholm, Sweden. His academic career spans over three decades, with key roles including membership in the research evaluation committee at the Danish Cancer Society (2009-2011) and chairman of the Swedish Cancer Society's research priority committee (2006-2009). He has been elected to prestigious institutions such as Academia Europaea (2009) and the European Molecular Biology Organization (EMBO, 2003), and received the Distinguished Professor Award at Karolinska Institutet (2010). Research Focus: Höög's laboratory investigates meiotic chromosome segregation, emphasizing the role of the synaptonemal complex—a conserved protein structure critical for accurate chromosome pairing and segregation during germ cell division. His work explores how defects in this complex contribute to aneuploidy, a leading cause of miscarriages, congenital disorders, and mental retardation in humans. By combining genetic, biochemical, and ultrastructural approaches, his research aims to uncover molecular pathways underlying meiotic errors and improve assisted reproductive technologies. Scientific Leadership: Current and past committee memberships in cancer and biomedical research institutions Member of the Nobel Assembly in Physiology or Medicine (2007) Honors and Awards: Distinguished Professor Award, Karolinska Institutet (2010) Academia Europaea member (2009) Nobel Assembly member (2007) EMBO member (2003) Flormanska Award (2003)

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Gabriel NeurohrView profile

Assistant Professor

ETH ZurichSwitzerland

Gabriel Neurohr serves as Assistant Professor in the Department of Biology at ETH Zurich, Switzerland, where he leads research on the physiological consequences of cell size dysregulation. His work bridges fundamental cell biology with implications for aging and cancer, investigating how deviations from species-specific cell size norms disrupt cellular homeostasis. Academic training includes a BSc in Biochemistry from ETH Zurich (2003-2006), PhD at Barcelona's Center for Genomic Regulation (2008-2012), and postdoctoral fellowship at MIT's Koch Institute (2013-2020). His research program addresses four core questions: (1) functional size limits of cells, (2) size-senescence relationships, (3) macromolecule-volume coordination, and (4) density-dependent functional impacts, employing genetic, live-imaging, and computational approaches in yeast and mammalian systems. Recent publications reveal a methodological evolution toward quantitative analysis, with machine-learning-enhanced imaging (2023) complementing mechanistic studies linking genome instability to size-induced senescence (2023). His 2024 work establishes cell enlargement as a primary driver of senescence through cytoplasmic dilution and organelle dysfunction, demonstrating conserved principles across eukaryotes. Major recognitions include: SNF Eccellenza Fellowship (2020-2025) EMBO Long Term Fellowship (2013-2014) ETH Medal for Master's excellence (2008) Neurohr's lab develops innovative tools like holotomography-based vacuole quantification while maintaining focus on fundamental size-regulation mechanisms. He teaches advanced courses on biomolecular condensates and cellular matter properties, mentoring through ETH's structured graduate programs. Current work explores therapeutic targeting of size-dependent senescence pathways in age-related diseases.

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Martin GullbergView profile

Professor

Umea UniversitySweden

Martin Gullberg is a Professor at the Department of Molecular Biology at Umeå University, Sweden. His research focuses on molecular mechanisms governing cellular processes such as microtubule dynamics, septin complex assembly, and their roles in cell polarization and disease. He has published extensively in leading journals including Molecular Biology of the Cell , Experimental Cell Research , and EMBO J . His work spans subfields like: Septin-Microtubule Interactions Chromosomal Instability in Leukemia Signal Transduction in T Cell Responses Bacterial Protein Secretion Systems The most recent publications highlight his contributions to understanding the Swedish pandemic response policies (2023) and Vibrio cholerae pathogenesis (2020), alongside foundational work on septins and tubulin regulation (2014–2004).

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Marin BarisicView profile

Associate Professor

University of CopenhagenDenmark

Marin Barisic is an Associate Professor at the University of Copenhagen's Department of Cellular and Molecular Medicine, where he is affiliated with the Morphogenesis and Differentiation Program. His research focuses on fundamental mechanisms of cell biology, particularly regulation of mitosis, cytoskeletal dynamics, and cell migration. With laboratories located at both Strandboulevarden and Blegdamsvej campuses, he maintains active research operations in Copenhagen. Barisic's research explores critical cellular processes including: Kinetochore-microtubule interactions during chromosome segregation Tubulin modification mechanisms in cell polarization Mitotic checkpoint signaling pathways Aurora kinase regulation in error correction Microtubule detyrosination in directed cell migration His work integrates biochemical, molecular, and cell biological approaches to study these fundamental processes. Analysis of his recent publications (2023-2025) reveals a consistent focus on mitotic regulation mechanisms, with particular emphasis on kinetochore dynamics, microtubule modifications, and kinase signaling pathways. His work frequently appears in high-impact journals including Nature Communications, EMBO Journal, and PNAS, demonstrating significant contributions to understanding cell division mechanics and migration.

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Sandhya ManoharView profile

Assistant Professor

University of ZurichSwitzerland

Sandhya Manohar is an SNF Ambizione Fellow and junior group leader at the University of Zürich's Department of Molecular Mechanisms of Disease. She holds a PhD in Chemical Biology from Harvard University (2020), completed postdoctoral research at ETH Zürich as an ETH Fellow, and was awarded the Life Sciences Switzerland PIs of Tomorrow public prize. Her research focuses on cell size regulation, cellular senescence, and genome homeostasis, integrating proteomic, genomic, and cell biological approaches. Education: B.S. in Biology/Mathematics at New York University; PhD at Harvard under Randy King; postdoc at ETH Zürich under Gabriel Neurohr. Research interests emphasize how cell size impacts cell cycle progression, DNA damage repair, and senescence. Key findings include the bidirectional relationship between size and senescence, proposing that excess size induces permanent cell cycle arrest. Current projects explore molecular mechanisms linking size to genome stability and drug response in cancer. Awards include SNSF Ambizione Grant (2024), ETH Career Seed Grant (2023), and ETH Fellowship (2021-2024). Active in science education, particularly outreach to underrepresented groups, and previously taught at Harvard and Emmanuel College. Labs/Teams: Manohar Lab at UZH focuses on experimental cell biology. Collaborates with Zurich's Cancer Research Center and Life Science Zurich networks. Recruits PhD students via MLS/LSZGS programs and undergraduate researchers directly.

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Judith CoppingerView profile

Senior Lecturer

Royal College of Surgeons in IrelandIreland

Judith Coppinger is a Senior Lecturer at RCSI's School of Pharmacy and Biomolecular Sciences, with dual affiliation as Principal Investigator at the National Children’s Research Centre since 2017. Her academic journey includes a PhD in Pharmacology from RCSI (2004), postdoctoral training at the Scripps Research Institute (2005-2011), and faculty roles at UC San Diego (2011-2013) and University College Dublin (2013-2017). Her research focuses on omics-based approaches to uncover dysregulated protein interactions in diseases like cystic fibrosis and cancer, with a particular emphasis on exosome-mediated signaling, kinase inhibitors for CFTR restoration, and BAG3 as a cancer therapeutic target. Key research areas include cystic fibrosis pathophysiology, lung cancer signaling pathways, and translational therapeutics. Her work spans basic science to clinical translation, such as investigating exosomes as biomarkers for disease progression and targeting the PI3K/Akt/mTOR pathway in cystic fibrosis. She has secured major grants including Science Foundation Ireland funding for exosome-based therapies and the Cystic Fibrosis Foundation for EV biomarker studies in CF. Judith has received awards including the Career Development Award (2014), Isenberg Fellowship (2011), and New Investigators Travel Award (2010). Her lab at RCSI collaborates with Trinity College Dublin and the National Children’s Research Centre to advance research in respiratory medicine and cancer biology. Teaching and supervision activities are integral to her role, contributing to training future biomedical researchers.

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Andrea MusacchioView profile

Professor

University of Duisburg-EssenGermany

Prof. Andrea Musacchio is Director of the Mechanistic Cell Biology Department at the Max Planck Institute of Molecular Physiology. His research investigates molecular mechanisms of cell division, focusing on kinetochore assembly, spindle checkpoint signaling, and chromosome segregation using biochemical reconstitution, structural biology, and cellular analyses. Awarded the Leibniz Prize (2020), he has pioneered structural insights into mitotic regulation. Research explores kinetochore-microtubule interactions, checkpoint complex assembly, phase separation in cellular organization, and structural mechanisms of chromosome segregation. Recent work examines PLK1 kinase in centromere maintenance and conformational regulation of motor protein recruitment. Honors include the Vallee Visiting Professorship and Leibniz Prize for contributions to understanding cell division machinery. Publications consistently integrate structural biology with functional analyses of mitotic components.

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Mathew JonesView profile

Senior Lecturer

University of QueenslandAustralia

Dr Mathew Jones serves as Senior Lecturer in the School of Chemistry and Molecular Biosciences at the University of Queensland and holds a Senior Research Fellow position at the Frazer Institute. His molecular genetics research group operates at the intersection of cancer biology and DNA repair mechanisms, with active supervision of multiple PhD students across diverse projects. His primary research focuses on exploiting cancer-specific vulnerabilities in DNA replication, repair pathways, and cellular metabolism to develop targeted therapies. Key areas include replication stress responses, mitotic regulation, chromosomal instability, and the interplay between DNA damage response and immune activation. His work combines cutting-edge molecular biology, genomics, and computational approaches to translate basic discoveries into therapeutic strategies. Analysis of his 15 most recent publications reveals a strong emphasis on DNA replication stress mechanisms (40% of papers), mitophagy regulation in cancer metabolism (20%), and chromosomal instability pathways (25%). His 2025 publications particularly highlight innovative applications of nanopore sequencing for cancer diagnostics and novel PARP1 inhibition mechanisms. Principal Investigator for 2023-2025 Schrodinger Inc. grant: 'Define the mode of action for Cdc7 inhibition in TP53 wild type and mutant Acute Myeloid Leukemia (AML)' Lead on 2021-2023 ARC Discovery Project: 'Decoding the spatiotemporal control of DNA replication and repair' Current supervision of 4 PhD students including projects on cGAS/STING pathway regulation and iPSC-NK cell immunotherapy His research group maintains active collaborations with the Frazer Institute's clinical research facilities, bridging laboratory discoveries with patient-oriented applications through the Frazer Institute's translational research framework.

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Mark CollinsView profile

Senior Lecturer

University of SheffieldUnited Kingdom

Dr. Mark Collins is a Senior Lecturer in Biological Mass Spectrometry and Deputy Director of the Mass Spectrometry Centre at The University of Sheffield's School of Biosciences. His expertise lies in proteomics, focusing on post-translational modifications (PTMs) such as palmitoylation and their roles in neurodegenerative diseases like Alzheimer's and ALS. He holds a PhD in Neuroscience from the University of Edinburgh and has extensive postdoctoral experience at the Wellcome Trust Sanger Institute. Education: PhD in Neuroscience, University of Edinburgh (2001-2005) BSc in Biochemistry, University College Dublin (1996-2000) His research interests include neuroproteomics, palmitoylation regulation, and ALS pathogenesis. He employs advanced mass spectrometry techniques to study protein dynamics and signaling pathways. Key collaborations include work with Prof. Shaun Cowley (University of Leicester) and Prof. Pamela Shaw (University of Sheffield). Dr. Collins teaches modules in cell/molecular biosciences and directs the Mass Spectrometry-based Proteomics and Metabolomics course. He has secured grants from BBSRC, MRC, and other organizations. His articles highlight contributions to understanding bacterial pathogenesis, epigenetic regulation, and ALS biomarkers. He supervises multiple PhD students and co-leads the Mass Spectrometry Centre, supporting interdisciplinary research in proteomics.

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Yumi KimView profile

Associate Professor

Johns Hopkins UniversityUnited States

Yumi Kim is an Associate Professor in the Department of Biology at Johns Hopkins University, within the Krieger School of Arts & Sciences. Her research focuses on the molecular mechanisms governing chromosome dynamics during meiosis, particularly in C. elegans. She received her Ph.D. from UC San Diego and completed postdoctoral research at UC Berkeley. Education: Ph.D., University of California San Diego Postdoctoral Research, UC Berkeley Research Interests: Dr. Kim investigates how chromosomes organize and interact during meiosis. Her work centers on synaptonemal complex formation, kinase regulation (e.g., Polo-like kinase), and the molecular basis of crossover assurance. She employs genetic, biochemical, and live-cell imaging approaches to dissect these processes. Publications: Her recent work highlights discoveries in synaptonemal complex components, kinase-substrate interactions, and checkpoint regulation. Key themes include C. elegans meiotic progression and spatial-temporal control of meiotic events. Awards: No scientific awards explicitly listed in the provided text. Advising & Grants: No student names or grant details provided, though her lab likely focuses on training graduate students in meiosis research. Lab activities involve protein biochemistry, microscopy, and genetic analysis. Labs/Teams: Her lab is located in 385 UTL with contact details available. Research emphasizes C. elegans as a model organism for studying conserved meiotic mechanisms.

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