Mathew Jones

Dr Mathew Jones serves as Senior Lecturer in the School of Chemistry and Molecular Biosciences at the University of Queensland and holds a Senior Research Fellow position at the Frazer Institute. His molecular genetics research group operates at the intersection of cancer biology and DNA repair mechanisms, with active supervision of multiple PhD students across diverse projects.

His primary research focuses on exploiting cancer-specific vulnerabilities in DNA replication, repair pathways, and cellular metabolism to develop targeted therapies. Key areas include replication stress responses, mitotic regulation, chromosomal instability, and the interplay between DNA damage response and immune activation. His work combines cutting-edge molecular biology, genomics, and computational approaches to translate basic discoveries into therapeutic strategies.

Analysis of his 15 most recent publications reveals a strong emphasis on DNA replication stress mechanisms (40% of papers), mitophagy regulation in cancer metabolism (20%), and chromosomal instability pathways (25%). His 2025 publications particularly highlight innovative applications of nanopore sequencing for cancer diagnostics and novel PARP1 inhibition mechanisms.

• Principal Investigator for 2023-2025 Schrodinger Inc. grant: 'Define the mode of action for Cdc7 inhibition in TP53 wild type and mutant Acute Myeloid Leukemia (AML)'
• Lead on 2021-2023 ARC Discovery Project: 'Decoding the spatiotemporal control of DNA replication and repair'
• Current supervision of 4 PhD students including projects on cGAS/STING pathway regulation and iPSC-NK cell immunotherapy

His research group maintains active collaborations with the Frazer Institute's clinical research facilities, bridging laboratory discoveries with patient-oriented applications through the Frazer Institute's translational research framework.