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Dr. Steven G. Clarke is a Distinguished Professor at UCLA Department of Chemistry & Biochemistry and director of research at the Molecular Biology Institute . His work bridges protein chemistry , methylation biology , and aging research through studies of spontaneous protein damage and its repair mechanisms. Education: BA in Chemistry and Zoology, Pomona College (magna cum laude, Phi Beta Kappa) PhD in Biochemistry and Molecular Biology, Harvard University (NSF Fellow) Postdoctoral Fellowship at UC Berkeley (Miller Fellow) Dr. Clarke's research focuses on protein isoaspartyl repair via PCMT1/PIMT enzymes , ribosomal protein methylation in Saccharomyces cerevisiae , and PRMT family characterization including PRMT7 and PRMT9. His lab combines biochemical assays , genetic models , and structural analysis to investigate aging mechanisms and disease implications. Recent publications highlight: COQ5 structure-function analysis in coenzyme Q biosynthesis PCMTD1 ubiquitin ligase interactions PRMT7 substrate specificity in histone H2B Protein isoaspartyl impacts on T cell function in lupus Novel PRMT inhibitors for cancer therapy Methionine addiction in osteosarcoma malignancy Major scientific awards: American Chemical Society Ralph F. Hirschmann Award in Peptide Chemistry NIH MERIT Award Ellison Medical Foundation Senior Scholar Award William C. Rose Award, ASBMB UCLA Distinguished Teaching Award (Eby Award winner) Current lab members include PhD candidates Eric Pang (UCSB) and Sining "Cindy" Wang (UCLA), while undergraduates Celeste Medina-Seymoure , Elizabeth Oroudjeva , Olivia Pacheco , and Jasmine Winter contribute to ongoing proteostasis studies. Collaborations with Profs. Jose Rodriguez and Catherine Clarke demonstrate interdisciplinary research approaches.

• Biochemistry
• Systems Biology
• Biological Regulation
• +8 more

Dr. Jacques Archambault is a Professor in the Department of Microbiology and Immunology at McGill University , and an associate member of the Division of Experimental Medicine since 2016. His research focuses on the molecular biology and pathogenesis of human papillomaviruses (HPVs) and polyomaviruses (HPyVs), with an emphasis on their replication mechanisms as episomes in host cells. The Archambault laboratory employs functional genomics, proteomics, and chemical biology approaches to identify cellular pathways exploited by these viruses and develop high-throughput assays for screening small molecule inhibitors of viral replication. Analysis of his recent publications reveals a strong focus on HPV and HPyV replication machinery, including studies on the E1 helicase, UAF1-USP1 interactions, and structural characterization of viral proteins involved in DNA replication. His work bridges virology, oncology, and drug discovery, particularly targeting oncogenic HPV types implicated in anogenital and oropharyngeal cancers, as well as HPyVs like BKPyV and JCPyV that cause pathologies in immunosuppressed patients. Current efforts in the lab aim to elucidate the molecular mechanisms by which HPVs and HPyVs replicate their genomes and to develop antiviral therapies targeting these processes. Techniques such as fluorescence anisotropy, NMR spectroscopy, and crystallography are frequently employed to study protein-DNA and protein-protein interactions critical to viral replication.

• Human Papillomavirus (HPV)
• Polyomavirus
• Viral DNA Replication
• +4 more

Joshua D. Rabinowitz is a Professor of Chemistry and the Lewis-Sigler Institute for Integrative Genomics at Princeton University, where he also serves as Director of the Ludwig Princeton Branch. His research focuses on achieving a quantitative, comprehensive understanding of cellular metabolism, with applications in both basic science and medical research. Dr. Rabinowitz's research interests span multiple areas of metabolism and systems biology: Quantitative analysis of metabolic networks and regulation Metabolomics and measurement of metabolite concentrations and fluxes Cancer cell metabolism and therapeutic targeting Metabolic regulation in microbes (E. coli, Saccharomyces cerevisiae) Biofuel production (focusing on Clostridium acetobutylicum) Metabolic impact of pathogen infection (viral infection of human cells) His laboratory has developed innovative methods for measuring cellular metabolites using state-of-the-art mass spectrometry technology and approaches for quantitating metabolic fluxes through isotope-labeling data interpretation. Analysis of recent publications reveals a strong focus on NAD+ metabolism, cancer metabolism, metabolic adaptations in disease states, and the intersection of metabolism with immunology and neuroscience, particularly in areas like T cell metabolism, Alzheimer's disease, and cardiac function. Dr. Rabinowitz has received recognition as a Highly Cited Researcher by Web of Science, indicating significant impact in his field. He advises several graduate students and has mentored numerous alumni, including Michel I. Nofal, Edmundo Leiva III, and Sean Hackett. His research is supported by multiple programs including NIH NHGRI Training Program and QCB Graduate Program. The Rabinowitz Lab operates at the intersection of chemistry, biology, and computational science, with all projects involving a mix of biological experiments, metabolomics, and computation to achieve their goal of a holistic understanding of cellular metabolism.

• Cellular Metabolism
• Metabolomics
• Systems Biology
• +5 more

Markus Babst is a Professor of Biological Sciences at the University of Utah, where he leads research at the Center of Cell and Genome Science. His work focuses on protein trafficking mechanisms in eukaryotic cells using Saccharomyces cerevisiae as a primary model system. His educational background includes: Diploma from Federal Institute of Technology, Switzerland Ph.D. from Federal Institute of Technology, Switzerland Dr. Babst's research centers on post-translational regulation of plasma membrane proteins through endocytosis and endosomal sorting. Key investigations include ESCRT-mediated protein sorting into multivesicular bodies for lysosomal degradation and eisosome-regulated storage of nutrient transporters. His work demonstrates how calcium signaling and proton gradients control eisosome disassembly and transporter endocytosis, revealing fundamental mechanisms of cellular stress adaptation. This research bridges membrane biophysics, metabolic regulation, and organelle dynamics. Analysis of his 15 most recent publications shows persistent thematic focus on membrane tension regulation, ESCRT complex dynamics, and nutrient transporter control. His work increasingly integrates mitochondrial metabolism with plasma membrane organization while maintaining yeast genetics as the core methodology. Recurring subfields include membrane contact sites, lipid domain organization, and stress-induced protein trafficking changes. Dr. Babst's scientific contributions are evidenced by his extensive publication record in high-impact journals, though specific awards are not documented in available sources. While student mentorship details are unavailable in the provided materials, his laboratory employs biochemical, genetic, and cell biological approaches to investigate membrane protein regulation. Grant funding specifics are not mentioned in the source text. His laboratory operates within the University of Utah's biological research ecosystem, utilizing S. cerevisiae to dissect conserved eukaryotic mechanisms. Current work emphasizes plasma membrane tension dynamics, ER-plasma membrane contact sites, and metabolic regulation of membrane protein trafficking, with implications for understanding cellular adaptation in changing environments.

• Protein Trafficking
• ESCRT Complexes
• Eisosomes
• +5 more

Miler T. Lee is an Associate Professor at the University of Pittsburgh , focusing on gene regulation during early embryonic development through high-throughput experimental and computational genomics. He earned his Ph.D. in Genomics and Computational Biology in 2009 from the University of Pennsylvania under Dr. Junhyong Kim, followed by postdoctoral work with Dr. Antonio Giraldez at Yale University. Joining the university in 2016, his research spans maternal-to-zygotic transition (MZT), RNA stability, pluripotency networks, and evolutionary developmental biology, utilizing model organisms like zebrafish, Xenopus, and Hydractinia symbiolongicarpus. Key Research Themes: Maternally inherited RNA dynamics during embryogenesis Mechanisms of RNA degradation and transcriptome remodeling Evolution of pluripotency networks in hybrid species Role of zinc signaling in fertilization barriers Computational tools for RNA regulation and sensing Scientific Awards: Pan-American Society for Evolutionary Developmental Biology Junior Faculty Award (2024) Outstanding New Investigator – International Xenopus Board (2023) Basil O'Connor Scholar – March of Dimes (2017-2019) Recent publications highlight his work on enhancer classification, RNA degradation mechanisms, and cross-species MZT comparisons. His lab develops innovative methods like RESA for regulatory sequence analysis and studies evolutionary divergence in RNA localization patterns. While the articles span computational and experimental approaches, they consistently address RNA's role in cellular identity, developmental timing, and evolutionary adaptation. Applications include understanding pluripotency, designing RNA biosensors, and elucidating fertilization barriers. Prospective Ph.D. students are encouraged to contact him for opportunities in gene regulation, development, evo-devo, and computational genomics.

• Gene Regulation
• Developmental Biology
• Computational Genomics
• +9 more

Adjunct Professor Robert Speight holds a position at Queensland University of Technology (QUT) within the Faculty of Science, School of Biology & Environmental Science. His primary role is Director of CSIRO's Advanced Engineering Biology Future Science Platform. He focuses on microbial biotechnology, enzyme engineering, and industrial biotechnology applications. His research spans protein engineering, microbial production systems, and biocatalyst development for industrial processes. Education: BSc (Chemistry) from Imperial College London (1996) PhD in Biochemistry from the University of Cambridge (2000) Research Interests: Enzyme optimization for industrial applications Microbial protein production systems Biocatalytic processes for chemical manufacturing Biorefinery development and techno-economic assessments Synthetic biology for future foods and sustainable bioproduction Grants & Projects: Lead investigator for the $6.5M Queensland Sustainable Aviation Fuel Initiative ARC Centre of Excellence in Synthetic Biology (2020–present) Biorefineries for Profit Phase 2 (RnD4Profit 2019) Collaborations: Works with industry partners and academic groups, including the ARC Centre of Excellence in Synthetic Biology and the Centre for Agriculture and Bioeconomy at QUT. Affiliations: President of Synthetic Biology Australasia CSIRO Director of Advanced Engineering Biology Future Science Platform Labs/Teams: Maintains collaborations in enzyme engineering and microbial systems through QUT’s adjunct role and CSIRO leadership.

• Industrial Biotechnology
• Synthetic Biology
• Enzyme Engineering
• +4 more

Dawn Louise Maskell is a Professor in the Institute of Biological Chemistry, Biophysics and Bioengineering within the School of Engineering & Physical Sciences at Heriot-Watt University. Her academic career spans brewing science, yeast physiology, and sustainable fermentation processes, with significant contributions to both academic research and industry applications. Education BSc (Hons) in Brewing & Distilling PhD in Brewing Yeast Physiology Diploma in Brewing from the Institute of Brewing & Distilling Professor Maskell's research focuses on yeast physiology, particularly how stress impacts brewing yeast performance and fermentation. Her work has expanded to encompass all aspects of yeast and fermentation science with emphasis on process improvements for sustainability. She actively contributes to UN Sustainable Development Goals through her research on circular economy approaches in brewing and distilling. Her publication portfolio reveals consistent scholarly output with 29 research contributions, showing increased productivity in recent years (5 publications in 2021 alone). The research trends demonstrate a clear progression from fundamental yeast physiology studies toward applied sustainability research, particularly in carbon dioxide valorization from fermentation and circular economy innovations in the brewing industry. Scientific Recognition Fellowship of the Chartered Institute of Brewers and Distillers (awarded July 2, 2025) Professor Maskell maintains significant professional engagement through multiple leadership roles. She serves on the Board of Directors of the American Society of Brewing Chemists (since 2021), chairs their Technical Committee, and sits on the Editorial Board of the Journal of the American Society of Brewing Chemists. She has been part of the Institute of Brewing & Distilling's Board of Examiners for the Diploma in Brewing since 2014. Her impact extends beyond academia through the Horizon Proteins project, which develops circular economy innovations converting whisky by-products into fish feedstock with documented economic and environmental benefits. Her professional standing is further evidenced by her status as a Liveryman of the Worshipful Company of Distillers and an Honorary Liveryman of the Worshipful Company of Brewers, along with holding the Freedom of the City of London.

• Yeast physiology
• Brewing science
• Fermentation technology
• +4 more

Raivo Jaaniso is an Associate Professor in Materials Science and Applied Physics at the Institute of Physics, Faculty of Science and Technology, University of Tartu. He has held this position since February 2024, having previously served as an Associate Professor from January 2021 to February 2024. Since June 2015, he has led the Sensor Technology Research Group and Laboratory at the University of Tartu. Dr. Jaaniso earned his Doctor's Degree in 1988 from the Institute of Physics, Estonian Academy of Sciences, with a dissertation titled "Spectrally selective processes of energy transformations in solid solutions of chlorophyll-like molecules," supervised by Jaak Kikas and Rein Avarmaa. His undergraduate studies in physics were completed at the University of Tartu from 1976 to 1981. Dr. Jaaniso's research focuses on graphene, sensor materials, gas sensors, optical spectroscopy, and pulsed laser deposition. His work spans materials science and applied physics, with particular emphasis on developing advanced sensor technologies for environmental monitoring and healthcare applications. He has pioneered research on graphene-based gas sensors, optical sensing materials, and nanomaterials for detection systems. Current projects include early diagnosis of neurodegenerative diseases with electronic nose technology and novel structures for gas microsensor arrays based on 2D materials. His recent publications reveal a strong trend toward graphene-TiO 2 heterostructures for gas detection, black aluminum films for thermal applications, and light-induced gas sensing mechanisms at room temperature. These works demonstrate his interdisciplinary approach combining materials science, optics, and sensor technology to address environmental and health monitoring challenges with practical solutions. University of Tartu Badge of Distinction (2023) Dr. Jaaniso has supervised numerous doctoral and master's students, including Martin Lind, Paniz Vafaei, and Ahmet Burak Baloglu who are currently completing their doctoral research. He has led significant research projects funded by the Estonian Research Council (totaling over €2 million in the past decade), European Commission, and industry partners including Infineon Technologies. His administrative roles include membership in the Graphene Flagship network and the NATO STO Exploratory Team on Novel Two-dimensional Materials for Military Applications. As head of the Sensor Technology Research Group, Dr. Jaaniso leads a multidisciplinary team focused on developing next-generation sensor technologies using 2D materials and advanced nanofabrication techniques. The group maintains active collaborations with international partners including the Czech Academy of Sciences and European research networks.

• Graphene
• Sensor Materials
• Gas Sensors
• +5 more

Aaron Hoskins is a full-time Professor of Biochemistry and Chemistry at the University of Wisconsin–Madison, where he leads an active research program focused on pre-mRNA splicing, spliceosome assembly, and single-molecule biophysics. He is affiliated with the Department of Biochemistry and the Hoskins Group laboratory, located in the Biochemical Sciences Building. Education: B.S., 2000 – Purdue University Ph.D., 2006 – Massachusetts Institute of Technology Postdoctoral Fellow, 2006–2011 – Brandeis University and UMass Medical School His research centers on understanding the molecular mechanisms of pre-mRNA splicing and spliceosome assembly in eukaryotes. Using single-molecule fluorescence microscopy, his lab investigates how the spliceosome recognizes RNA targets, how ribonucleoproteins are assembled, and how splicing fidelity is maintained or disrupted in disease. His work integrates genetics, chemical biology, and biophysical approaches to dissect spliceosome dynamics and to develop new tools for studying RNA processing. Aaron Hoskins has published over 80 peer-reviewed articles since 2004, with recent work appearing in RNA , eLife , Structure , and Cell Chemical Biology . His research trends include the structural dynamics of spliceosomal snRNPs, cancer-associated mutations in splicing factors, and the development of splicing inhibitors as potential therapeutics. His lab also explores translational applications, including the use of humanized yeast strains for drug screening. He is supported by multiple NIH grants (R01 GM053007, R01 GM112735, R01 GM081648) and has collaborated extensively with UW-Madison colleagues David Brow and Samuel Butcher. His lab is equipped with custom-built fluorescence microscopes for single-molecule imaging and is actively training the next generation of scientists in RNA biology and biophysics.

• Pre-mRNA splicing
• Spliceosome assembly
• Single-molecule fluorescence microscopy
• +3 more

Per Bruheim is a Professor at the Department of Biotechnology and Food Science, Norwegian University of Science and Technology (NTNU). He leads the Bruheim research group, focusing on Deep Phenotyping of prokaryotic and eukaryotic systems using advanced metabolomics, fluxomics, and lipidomics techniques. He is the scientific leader of the NV faculty Mass Spectrometry lab and has developed targeted/non-targeted MS methods applied to diverse biological systems. Teaching roles include leading the 2-year and 5-year Biotechnology programs (MSBIOTECH and MBIOT5). He teaches courses such as TBT4140 Biochemical Engineering, TBT4110 Microbiology, and TKP4170 Process Design. Current research projects include targeting antibiotic resistance via bacterial stress responses (Trond Mohn Foundation), chemically defined cell culture media development, and peptide drug inhibition of translesion synthesis mechanisms. Research interests center on metabolomics and systems biology approaches to study microbial physiology and antibiotic resistance, with applications in bioprocessing and sustainable protein production. His lab employs mass spectrometry for precise metabolic profiling and collaborates internationally on projects involving lipidomics and flux analysis. Advising and grants involve mentoring over a dozen master’s theses on topics like microbial fermentation optimization, single-cell protein production, and recombinant protein expression. He actively pursues funding for projects addressing AMR mechanisms and bioprocess innovation. The Bruheim group also collaborates with industry on sustainable raw material utilization for microbial cultures. Labs/Teams: Leads the Mass Spectrometry facility at NTNU and directs the Bruheim research group within the Institute of Biotechnology (IBT). Collaborates with national/international partners in microbiology, metabolomics, and bioprocessing.

• Metabolomics
• Antibiotic Resistance
• Biotechnology
• +5 more

Edel Hyland is a Senior Lecturer in Biochemistry at Queen's University Belfast's School of Biological Sciences, affiliated with the Institute for Global Food Security since 2015. Her research examines how genome architecture influences environmental adaptation through chromatin dynamics, utilizing yeast pathogens from the Saccharomycotina subphylum with active PhD recruitment in antifungal resistance. Her academic training includes a BSc in Biochemistry from Trinity College Dublin (1996-2000), PhD under Prof. Jef Boeke at Johns Hopkins School of Medicine (2002-2008), and postdoctoral work at Harvard Medical School (2001-2002), Harvard University (2009-2014), and Dublin City University (2014-2015). Research centers on chromatin-based gene regulation mechanisms across evolutionary timescales, specifically investigating: experimental evolution of Saccharomyces cerevisiae histone variants, CRISPR-Cas9 reverse genetics in Candida glabrata virulence, and comparative epigenomics of histone marks in fungal pathogens. This work directly addresses antifungal resistance and phenotypic plasticity in human-infecting yeasts. Recent publications (2019-2023) reveal strong interdisciplinary trends combining medical mycology with evolutionary genomics, particularly in Candida drug resistance mechanisms. Parallel work extends to malaria pathogenesis (Plasmodium transporters) and innate immune evolution, consistently applying chromatin analysis to pathogen adaptation challenges. She holds the Charles A. King Postdoctoral Fellowship award and serves as Co-Investigator on two major research projects: IMMACULATE: Improving Mass Spectrometry Sustainability in Food, Environmental, and Health Research (2023-present) Phosphorus from wastewater: Novel technologies for advanced treatment and re-use (2014-present) Hyland coordinates undergraduate Experimental Biochemistry (BIO2102) and MSc Protein Structure & Function (BBC8039) modules while actively supervising PhD students. Her laboratory focuses on yeast epigenetics within the Institute for Global Food Security, maintaining international collaborations evidenced by co-author networks spanning the USA, Ireland, and UK, and participates in science outreach including the Northern Ireland Science Festival.

• Genome Architecture
• Chromatin Biology
• Epigenetics
• +5 more

Andrea Rocco is an Associate Professor in Physics and Mathematical Biology and Head of the Quantum Sciences Research Group at the University of Surrey. He holds affiliations with the School of Mathematics and Physics and the Centre for Mathematical and Computational Biology. Rocco earned his PhD in Physics from the University of North Texas (1998) and held postdoctoral positions at the University of Barcelona, University of Rome La Sapienza, CWI (Netherlands), and the University of Oxford. His research bridges theoretical physics (quantum mechanics, open systems, decoherence) and biological physics (stochastic dynamics in living systems, gene networks). Educations: BSc in Physics, University of Pisa (1994) PhD in Physics, University of North Texas (1998) Research Interests: His work explores quantum-classical transitions, quantum thermodynamics, and noise-induced phenomena in biological systems. Recent grants include a US$3M award for studying time and life. He is a Fellow of the Royal Society of Biology and the Higher Education Academy. Awards: Member of the Institute of Physics (MInstP) Fellow of the Higher Education Academy (FHEA) Fellow of the Royal Society of Biology (FRSB) Advising & Grants: Rocco leads the Quantum Sciences Group and has supervised postdoctoral researchers like Thomas Guff. His grants include major funding for interdisciplinary quantum-biological research. Labs/Teams: Head of the Quantum Sciences Research Group at Surrey, integrating theoretical physics and computational biology.

• Theoretical Physics
• Quantum Mechanics
• Biological Physics
• +3 more

Hal Alper is a Professor and holds the Cockrell Family Regents Chair in Engineering at the University of Texas at Austin's Department of Chemical Engineering. His research lab focuses on rewiring cellular metabolism for biomanufacturing applications, including biofuels, pharmaceuticals, and sustainable materials, using synthetic biology, directed evolution, and pathway engineering. Education: Postdoctoral Research Associate, Whitehead Institute for Biomedical Research (2006-2008) Postdoctoral Research Associate, Shire Human Genetic Therapies (2007-2008) Ph.D., Chemical Engineering, Massachusetts Institute of Technology (2006) B.S., Chemical Engineering, University of Maryland, College Park (2002) Research Focus: The Alper Lab specializes in metabolic and cellular engineering to address global challenges in sustainability and health. Core methodologies include synthetic biology tool development, high-throughput screening platforms (e.g., biosensor-in-microdroplet systems), and evolutionary engineering of yeast strains like Saccharomyces cerevisiae and Yarrowia lipolytica . Key application areas are biofuels, biochemicals, polymer precursors, and pharmaceuticals. Publication Trends: Recent work emphasizes machine learning-assisted enzyme engineering, microbial consortia design, and advanced screening techniques for metabolic phenotypes. A consistent theme across publications is the optimization of yeast hosts for efficient bioproduction through promoter engineering, transporter modification, and evolutionary strategies. Awards & Honors: Fellow, American Association for the Advancement of Science (2024) Andreas Acrivos Award (AIChE, 2023) Fellow, National Academy of Inventors (2019) O'Donnell Award in Engineering (2019) AIChE Colburn Award (2018) Society for Industrial Microbiology Young Investigator (2015) Dreyfus Teacher-Scholar (2014) Regents’ Outstanding Teaching Award (2012) ONR Young Investigator (2011) Lab Leadership: Directs the Laboratory for Cellular and Metabolic Engineering, fostering interdisciplinary work in synthetic biology and bioprocess development. The lab prioritizes inclusivity and collaborative research, with projects spanning genetic toolkit development, metabolic flux analysis, and scalable biomanufacturing platforms.

• Biotechnology
• Metabolic Engineering
• Cellular Engineering
• +6 more

Heather R. Christofk is a Professor in the Department of Biological Chemistry at the David Geffen School of Medicine at UCLA. Her research focuses on the intricate relationship between cellular metabolism and various biological processes, particularly in the contexts of cancer development, stem cell function, and viral infections. Education: PhD in Cell and Developmental Biology from Harvard University (2007) BS in Molecular, Cell, and Developmental Biology from UCLA (2001) Dr. Christofk's research program centers on understanding how metabolic pathways regulate cellular processes in both normal physiology and disease states. Her laboratory has made significant contributions to understanding how cancer cells reprogram their metabolism to support rapid growth and proliferation, with particular focus on glucose metabolism, amino acid utilization, and metabolic adaptations in tumor microenvironments. She has also pioneered work on the metabolic regulation of stem cell function, especially in hair follicle stem cells, demonstrating how metabolic pathways control stem cell activation and differentiation. Her research has important implications for developing novel therapeutic approaches that target cancer metabolism while preserving normal tissue function. Analysis of Dr. Christofk's recent publications reveals a strong focus on metabolic heterogeneity across different biological contexts. Her work spans cancer metabolism (particularly in liposarcoma, melanoma, and hepatocellular carcinoma), stem cell metabolism (especially hair follicle stem cells), viral metabolism (including Epstein-Barr virus and Zika virus), and developmental metabolism (fetal development and organogenesis). A recurring theme is how metabolic pathways serve as regulatory nodes that control cell fate decisions, tumor progression, and therapeutic responses. Selected Research Funding: Metabolic Control of Hair Follicle Stem Cell Homeostasis and Tumorigenesis (NIH R01AR070245, 2018-2023) - Co-Principal Investigator Nutrient regulation of cancer cell growth (NIH R01CA215185, 2017-2022) - Principal Investigator Regulation of the Warburg Effect in Cancer (NIH DP2OD008454, 2011-2016) - Principal Investigator Dr. Christofk's laboratory maintains active collaborations across multiple disciplines, working with clinicians, basic scientists, and computational biologists to address complex questions in metabolism and disease. Her team employs a range of cutting-edge techniques including metabolomics, stable isotope tracing, molecular biology, and in vivo models to investigate metabolic regulation in health and disease.

• Cancer Metabolism
• Stem Cell Metabolism
• Metabolic Regulation of Cell Growth
• +5 more

Prof. Dr. Christian Ungermann is a Professor in the Department of Biochemistry at the University of Osnabrück, Germany. His research focuses on the molecular mechanisms underlying endosome, lysosome, and autophagosome biogenesis. He combines cell biological methods with in vitro reconstitution assays to study protein complexes involved in these processes. His work is critical for understanding disease-related mechanisms linked to organelle dysfunction. Research topics include endosomal maturation, autophagosome/lysosome biogenesis, and endosomal signal transduction. Model systems include Saccharomyces cerevisiae, insect cells, and Drosophila melanogaster. Key methods are protein purification, fluorescence microscopy, membrane fusion assays, and enzymatic activity assays. Recent publications highlight studies on Rab GTPase regulation, endosomal Rab transitions, and CORVET tethering complex structure, reflecting expertise in membrane trafficking and organelle dynamics.

• Molecular Biology
• Cell Biology
• Autophagy
• +3 more