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Bertrand Coste is a CNRS Researcher at the Cognitive Neuroscience Laboratory (Aix-Marseille University/CNRS), specializing in mechanosensation and ion channel biology. He developed pioneering techniques to study mechanically activated ion channels, notably discovering the PIEZO1 and PIEZO2 channels with Prof. Ardem Patapoutian, which contributed to the 2021 Nobel Prize in Physiology or Medicine. His current work focuses on pain perception mechanisms and cardiovascular functions of PIEZO channels. Education: Completed his PhD at the Laboratoire de neurophysiologie cellulaire in Marseille, followed by postdoctoral research at the Scripps Research Institute, CA (2007–2012). Research Interests: Molecular basis of mechanosensation, mechanosensitive ion channels (PIEZO family), pain signaling, and cardiovascular physiology. His studies bridge molecular neurobiology with clinical applications in chronic pain management and genetic disorders linked to mechanosensory defects. Publications highlight advancements in PIEZO channel structure-function relationships, their roles in sensory perception, and contributions to pathologies like hereditary stomatocytosis and arthrogryposis. His work integrates genetics, cell biology, and biophysics to decode mechanical signaling pathways. Received the Brixham Foundation 2022 Award (Fondation pour la Recherche Médicale) for research on pain mechanisms. Collaborates with interdisciplinary teams at the CNRS and Aix-Marseille University, advancing translational neuroscience initiatives.

• Mechanosensation
• Neuroscience
• Molecular Biology
• +3 more

Julia Chamot-Rooke is a Principal Investigator and Researcher at the Institut Pasteur in Paris, France, affiliated with the Department of Structural Biology and Chemistry and the Mass Spectrometry for Biology unit (UTechS MSBio), a joint CNRS service and research unit (USR2000). She leads multiple projects in advanced proteomics and is the PI for the Institut Pasteur in the European Proteomics Infrastructure Consortium providing access (EPIC-XS). Her research focuses on developing innovative methods in top-down proteomics , cross-linking mass spectrometry , and structural proteomics to study intact proteins, post-translational modifications, and protein complexes. Her work has applications in microbiology, infectious diseases, and host-pathogen interactions. She has developed the ProteoCombiner software to integrate proteomics data for improved proteoform characterization. The recent publications reflect a strong emphasis on structural and functional proteomics , particularly in microbial systems and immune interactions. Trends include the use of advanced mass spectrometry techniques (HDX-MS, cross-linking MS, top-down MS) to investigate protein structure, dynamics, and interactions in pathogens and host systems. There is also a growing focus on software and tool development to enhance data analysis and reproducibility in proteomics. Principal Investigator, EPIC-XS at Institut Pasteur Coordinator, Joint Research Activity on Future and Emerging Proteomics Technologies Lead Developer, ProteoCombiner software She supervises PhD students and research engineers and collaborates widely on projects involving bacterial pathogenesis, immune evasion, and structural biology. Her lab is equipped with state-of-the-art Orbitrap mass spectrometers and participates in transnational access programs, providing cutting-edge proteomics services to the European research community.

• Proteomics
• Structural Biology
• Mass Spectrometry
• +7 more

Dr. Vianney Pichereau is a University Professor at the LEMAR Laboratory (Laboratoire d'Excellence Mer) within the University of Western Brittany. His research focuses on environmental impacts on marine organisms, integrating proteomics, omics approaches, and microbiology to assess ecosystem health. Key projects include studies on Vibrio-bivalve interactions, brown ring disease, and the effects of climate change and pollution on estuarine species. He leads investigations into stress responses in marine organisms such as flounder, scallops, and oysters, using cutting-edge techniques like proteomics and transcriptomics. His work addresses urgent issues like eutrophication, industrial accidents, and ocean acidification, with applications in biomonitoring and aquaculture. Dr. Pichereau collaborates on interdisciplinary projects including CLIMCLAM, IRP CORRIENTE, and VIVALDI, focusing on coastal ecosystem resilience. His lab employs cell culture models to study bivalve pathogens and has pioneered biomarker approaches for chemical risk assessment in heavily polluted environments like the Seine estuary.

• Environmental Science
• Marine Biology
• Proteomics
• +3 more

Lucy Glover is a Researcher and Group Leader of the Trypanosome Molecular Biology laboratory at the Department of Parasites and Insect Vectors, Institut Pasteur, Paris, France. She joined the institute in March 2016 as a G5 group leader, focusing on the molecular mechanisms of antigenic variation and DNA repair in Trypanosoma brucei , the causative agent of Human African Trypanosomiasis. Her research integrates molecular, biochemical, and high-throughput approaches to study DNA recombination and immune evasion. Institut Pasteur, Paris (2016–Present) PhD, London School of Hygiene and Tropical Medicine Her research interests center on antigenic variation , DNA repair , and homologous recombination in trypanosomes. She investigates how DNA double-strand breaks influence variant surface glycoprotein (VSG) switching, a critical process for parasite survival in the host. Her lab uses advanced techniques such as RIT-seq, phosphoproteomics, and CRISPR-based tools to dissect these mechanisms at the molecular level. The recent publications of Lucy Glover span molecular parasitology, DNA damage response, and diagnostic development. Key themes include the role of the MRN complex in DNA repair, phosphoproteomic profiling of DNA damage responses, and the design of CRISPR-based diagnostics for HAT. Her work reveals how chromosomal context influences repair pathways and antigenic variation, contributing to a deeper understanding of parasite biology. While no formal scientific awards are listed in the provided text, her contributions are evident through high-impact publications and leadership in collaborative research projects. Lucy Glover advises several PhD and postdoctoral researchers, including Emilia MacLaughlin, Nuria Sima Teruel, and Alix Thivolle. Her lab is supported by institutional initiatives such as LabEx IBEID and transversal drug discovery programs. She collaborates with teams working on host-pathogen interactions, genomics, and infectious disease epidemiology. Her laboratory is part of the Department of Parasites and Insect Vectors and participates in departmental retreats and seminars. The team includes post-docs, research engineers, and administrative staff, reflecting a collaborative and interdisciplinary research environment focused on combating neglected tropical diseases.

• Molecular Parasitology
• DNA Repair
• Antigenic Variation
• +7 more

Denis Mestivier serves as a Professor of Bioinformatics at the University of Paris-Est Créteil, where he leads the bioinformatics platform of the Mondor Institute of Biomedical Research (IMRB) under the Faculty of Health. His multidisciplinary expertise bridges computational and biological sciences, with a career-long focus on health-related applications of data-intensive methods. Education: Master's degree in Molecular Genetics PhD in Biomathematics Research Interests: Mestivier develops computational models and bioinformatics pipelines for large-scale biological datasets, specializing in microbiome-cancer interactions and molecular biomarker discovery. His work integrates statistical analysis, metagenomics, and epigenetic modeling to address clinical health problems, particularly in gastrointestinal and liver diseases, through active collaboration with experimental research teams. Publication Trends (2011-2021): His research demonstrates a clear trajectory from metabolic modeling (2011) to translational microbiome studies in colorectal cancer (2019-2021), emphasizing bias mitigation in metagenomics and epigenetic mechanisms linking microbiota to oncogenesis. All works showcase applied bioinformatics in health contexts, with consistent focus on clinical biomarker identification and computational solutions for complex biological systems. Scientific Awards: No awards, fellowships, or medals are documented in the provided text. Teaching and Leadership: Since the 1990s/2000s, Mestivier has pioneered biology-computing curriculum development at the university level, intensifying health-focused teaching after his Faculty of Health appointment. He directs IMRB's bioinformatics platform but specific advising roles or grant funding details are not disclosed. Labs and Teams: As head of IMRB's bioinformatics platform, he oversees computational infrastructure for biomedical research, facilitating cross-disciplinary projects with experimental teams at the Mondor Institute while specializing in health data analysis.

• Bioinformatics
• Computational Biology
• Data Analysis
• +3 more

Eliane Piaggio is an Inserm Research Director and Team Leader of the Translational Immunotherapy team at the Institut Curie Research Center (Unit U932 - Immunity and Cancer). Her work focuses on immunotherapy strategies targeting regulatory T lymphocytes in cancer, infectious diseases, and autoimmunity. Studied lymph nodes draining human tumors to identify functional T cell responses Developed IL-2 variants for tumor-specific Treg inhibition Explored neoantigen responses in breast, head/neck, and melanoma cancers Key research areas include tumor microenvironment analysis, biomarker discovery, and personalized immunotherapy development. Her team has established a tumor-draining lymph node biobank and employs advanced technologies like single-cell transcriptomics, CRISPR editing, and mass spectrometry immunopeptidomics. Notable achievement: 2022 Ruban Rose Avenir prize recipient for predictive biomarker research in triple-negative breast cancer. Her projects aim to optimize anti-tumor immune responses through translational approaches in rhabdoid cancers and neoantigen vaccination studies.

• Immunotherapy
• Cancer Immunology
• Regulatory T Cells
• +3 more

Sylvain Brisse is a Researcher at the Institut Pasteur , leading the Biodiversity and Epidemiology of Bacterial Pathogens lab. His work focuses on three major public health threats: multidrug-resistant Klebsiella pneumoniae , Bordetella pertussis (whooping cough), and Corynebacterium diphtheriae (diphtheria). Key Research Areas: Genomic epidemiology and population biology of bacterial pathogens Integrative approaches combining microbiology, proteomics, and bioinformatics Development of genomic nomenclature systems via BIGSdb-Pasteur Projects: Principal Investigator for the European Reference Laboratory for Public Health on Diphtheria and Whooping Cough Coordinator of the KlebNet One Health network for Klebsiella surveillance Lead for Genomic taxonomy initiatives establishing universal strain nomenclature Recent Publication Trends (2025-2022) demonstrate: 75% focus on Klebsiella pneumoniae genomics and resistance mechanisms 15% on Bordetella vaccine escape and disease severity 10% on Corynebacterium species evolution and toxin production

• Bacterial Epidemiology
• Genomic Surveillance
• Antimicrobial Resistance
• +4 more

Véronique Stoven is a Professor at Mines Paris Tech and holds a research position within the Curie Institute as a Research Teacher. She leads work in the Cancer Systems Biology team (Unit: Computational Oncology U1331). Research Focus: Computational biology, protein-ligand interactions, and machine learning for drug candidate design. Applies systems biology approaches to study triple-negative breast tumors (TNBC) and cystic fibrosis in respiratory epithelial cells. Publications highlight trends in: Omics data integration for disease modeling (2024) Benchmarking machine learning techniques in molecular informatics (2023) SLC transporter analysis in cystic fibrosis research (2022)

• Computational Biology
• Machine Learning
• Protein-Ligand Interactions
• +6 more

Edor Kabashi is a leading researcher in translational neuroscience, specializing in genetic causes of neurological disorders such as Developmental and Epileptic Encephalopathy (DEE), Spinal Muscular Atrophy (SMA), Amyotrophic Lateral Sclerosis (ALS), and Frontotemporal Dementia (FTD). His team at the Imagine Institute (Necker Hospital site) develops advanced cellular and zebrafish models to elucidate disease mechanisms and accelerate therapeutic validation. Key research areas include iPSC-derived neurons, drug screening platforms, and genomic sequencing analysis. Collaborations span national/international networks with institutions like ANR and pharmaceutical partners. Expertise: Genetic epilepsy, neurodegeneration, translational drug development Techniques: CRISPR gene editing, induced pluripotent stem cells, high-throughput screening Current projects focus on fast-tracking neuroprotective compounds into clinical trials, leveraging state-of-the-art platforms such as transcriptomic/proteomic analysis and advanced imaging. Actively recruiting postdocs and PhD candidates with expertise in zebrafish models, molecular genetics, and bioinformatics.

• Neurological Disorders
• Neurodevelopmental Diseases
• Neurodegenerative Diseases
• +5 more

Frédéric BERTRAND is a Full Professor at the Université de Technologie de Troyes (UTT), part of the Computer Laboratory and Digital Society (LIST3N). He previously held positions at the Université de Strasbourg and Institut de Recherche Mathématique Avancée (IRMA). His academic qualifications include a habilitation to direct research (HDR) from the Université de Strasbourg, a Ph.D. from Université Louis Pasteur, and membership in the École Normale Supérieure de Lyon. He specializes in statistical modeling, machine learning, and artificial intelligence, with applications in bioinformatics, biostatistics, and medical data analysis. Roles and Affiliations: Full Professor at UTT Director of the Mastère Spécialisé in Big Data Analytical and Decisional Aspects Responsible for the OSS ED361 SPI specialty Responsible for the PEA Impact program Member of the LIST3N laboratory Research Interests: His work focuses on statistical and machine learning methods applied to complex systems, including bioinformatics, medical data analysis, and process mining. Key areas include Bayesian networks, partial least squares regression (PLS), variable selection algorithms, and handling missing data in large-scale datasets. He has developed multiple R packages, such as selectBoost , bootPLS , and Patterns , which are widely used in statistical modeling and data analysis. Publications and Contributions: He has authored/co-authored over 38 scientific articles, 14 books, and 14 R packages. His research emphasizes methodological advancements in statistics and their practical applications in biology, healthcare, and industry. Notable contributions include developing algorithms for high-dimensional data analysis and collaborative projects on cancer genomics and proteomics. Teaching: He teaches advanced courses in statistics, mathematics, and data analysis at the graduate and postgraduate levels, including modules on uncertainty analysis and complex systems at UTT and the Université de Strasbourg.

• Statistical Modelling
• Statistical Learning
• Artificial Intelligence
• +5 more

Thomas Bourgeron is a Professor and head of the Human Genetics and Cognitive Functions Unit at the Institut Pasteur in Paris, France. His research integrates psychiatry, neuroscience, and genetics to investigate the causes of autism spectrum disorders (ASD) and improve clinical management. He leads a multidisciplinary team and numerous international research initiatives. Institut Pasteur, Paris Human Genetics and Cognitive Functions Unit Principal Investigator, EU-AIMS, PARIS Study, Phelan-McDermid Syndrome Project His research focuses on identifying genetic mutations linked to ASD, particularly in synaptic genes (NLGN, SHANK, CNTN) and the melatonin pathway affecting sleep. His team employs high-throughput genomics, brain imaging (MRI, EEG), mouse models, and human iPSCs to study functional impacts and develop therapeutic strategies. He emphasizes data sharing and open science through tools like GeneTrek and GRAVITY. His recent publications reveal genetic heterogeneity in autism, brain connectivity patterns, and phenotypic stratification using electrophysiology and behavioral analysis. His work bridges molecular mechanisms with clinical manifestations, aiming to identify common pathways for targeted interventions. Phenotypic effects of genetic variants in autism Genetic correlates of phenotypic heterogeneity Stratification of autistic phenotypes using EEG Functional impact of SHANK3 mutations Proteomic analysis of the pineal gland in autism Thomas Bourgeron mentors numerous PhD students, postdoctoral researchers, and engineers. He collaborates with leading institutions and clinicians, including Professor Christopher Gillberg at the University of Gothenburg. His lab is actively recruiting in human genetics and neuroimaging. He contributes to public education through lectures, open-access tools, and outreach initiatives like the CléPsy platform and educational videos for families of autistic children.

• Genetics
• Genomics
• Autism Spectrum Disorders
• +12 more

Florent Ginhoux is a Researcher at Gustave Roussy 's Tumor Immunology and Cancer Immunotherapy Program (U1015). He leads the Florent Ginhoux Laboratory (ginhouxlab.com), focusing on myeloid cell biology in cancer progression and immunotherapy development. His team integrates spatial transcriptomics (Visium HD, Xenium), single-cell RNA sequencing , and MACSIMA spatial proteomics to dissect tumor-immune interactions. His research spans pediatric oncology (brain tumors, neuroblastomas, sarcomas) and adult cancers (pancreatic, head/neck carcinomas). Key projects include Developing iPSC-derived macrophages for patient-specific tumor modeling Characterizing TREM2+ multinucleated macrophages as prognostic indicators Creating MoMac-VERSE and DC-VERSE compendiums for cross-tissue myeloid cell analysis His lab collaborates with pediatric oncologists and bioinformaticians on projects funded by 2024 Fight-Kid Cancer grant ( MiMiC-Kids ) 2024 ANR Excellence Chair ( MATCH ) 2024 Horizon HIT-GLIO grant 2021 INCa PEDIAHRG High-Risk/High-Gain program

• Myeloid Cell Biology
• Cancer Immunology
• Tumor Microenvironment
• +4 more

Hervé Cardot is a Professor of Statistics and team leader of the Statistics, Probability, Optimization and Control (SPOC) group at the Institut de Mathématiques de Bourgogne (IMB) , University of Burgundy. His research spans functional data analysis, stochastic algorithms for robust estimation, survey sampling methodology, and applied statistics across diverse fields. Research Interests : Functional data analysis, online principal component analysis, zero-inflated regression, survey sampling, nonparametric estimation Key Applications : Agriculture, climatology, energy consumption, food science, remote sensing, medical imaging Recent Work includes: Developing statistical frameworks for analyzing categorical trajectories using multivariate functional PCA (2025) Advancing bias-robust estimation for functional data in survey sampling (2020) Creating online stochastic algorithms for high-dimensional robust estimation (2017) Applying semi-Markov models to sensory analysis (2018) Teaching at the University of Burgundy includes courses on statistical modeling, big data analysis, and applied statistics for economics and psychology. He supervises PhD students in statistics and co-edits Statistics and Probability Letters .

• Functional Data Analysis
• Stochastic Algorithms
• Survey Sampling
• +10 more

Françoise Nau is a Professor of Food Science at the Agro Institute Rennes-Angers , affiliated with the Department of Animal Production, Agrifood, Nutrition (P3AN) and the UMR STLO (Science & Technology of Milk & Eggs) research unit. Her career spans academic, research, and industrial development roles, with a focus on egg and milk protein functionality, bioactive properties, and nutritional quality. Doctor of Engineering in Agronomic Sciences from ENSAR (1993), specializing in 'Animal Production Science and Technology' Accreditation to Direct Research (HDR) prior to becoming a Professor in 2003 Former R&D engineer at Sopharga (Roussel-Uclaf), Nutripharm-Gallia (Danone), and Ovonor Her teaching emphasizes ingredient functionality , physical chemistry of food , and statistical process control , across M1-M2 and L2 levels. Research themes include: Characterization of egg white proteins using proteomics and molecular biochemistry Valorization of egg proteins via chromatographic techniques Exploration of egg white’s antimicrobial activity under thermal treatments Impact of food processing on nutrient digestibility and bioavailability (via in vitro and in vivo models) Statistical analysis of pepsin action on peptidomic datasets Collaborations with UMR STLO’s Microbiology and Statistics teams, and leadership of the ANR-funded OvoNutriAl project (2008–2011) on egg processing and allergenicity. Contact: francoise.nau@institut-agro.fr

• Food Science
• Animal Product Technology
• Nutritional Science
• +6 more

Irene Netchine is a leading researcher in pathophysiology of fetal growth , affiliated with Sorbonne University and Saint-Antoine Hospital in Paris, France. Her work focuses on the IGF system and parental imprinting in growth-related disorders, including Silver-Russell syndrome (SRS) , Beckwith-Wiedmann syndrome (BWS) , and Temple syndrome (TS14) . PU-PH (HDR) at Sorbonne University Team Leader at Saint-Antoine Hospital Her research spans genomic imprinting , epigenetic methylation , and IGF signaling , with a focus on molecular mechanisms of 11p15 and 14q32 imprinting disorders. She has developed high-throughput sequencing panels for diagnosing fetal growth anomalies and pioneered iPSC models with balanced methylation for studying imprinting pathologies. Recent publications highlight her expertise in cellular modeling of imprinting disorders, environmental influences on methylation, and clinical-genomic correlations in rare growth syndromes. She leads the RADICO-IDMET cohort and contributes to international consensus statements on SRS management.

• Fetal Growth Disorders
• Genomic Imprinting
• Epigenetics
• +2 more