Shelley WickhamView profile
Associate Professor
Dr. Shelley Wickham is an Associate Professor and ARC DECRA Fellow at the University of Sydney, holding joint appointments in the Schools of Chemistry and Physics. She serves as a Westpac Research Fellow and leads the DNA Nanotechnology Group at the Sydney Nano Institute. Dr. Wickham is also co-Champion of the Sydney Nano Institute Grand Challenge project in Molecular Nanorobotics for Health, co-lead of the School of Physics Grand Challenge on Nanoscale brain navigation for targeted drug delivery, and faculty mentor of the University of Sydney BIOMOD team. Bachelor of Science and Master of Science in Physics from University of Sydney PhD in Condensed Matter Physics from University of Oxford Postdoctoral Fellow at Harvard Medical School, Dana-Farber Cancer Institute, and Wyss Institute Dr. Wickham's research focuses on self-assembling nanotechnology and molecular robotics, particularly in the design and assembly of programmable nanostructures out of DNA. Her work spans applications in cell biology, materials science, and nanomedicine. Current research projects include design and synthesis of self-assembling DNA nanostructures, proto-cells made of DNA gels that move under flow, new plasma fabrication methods for biomolecule micropatterning, and DNA computation circuits for navigating the brain using machine learning. Her research aligns with the Faculty of Science Research Strengths in Molecules to Materials, Preventing and Treating Disease & Disorder, and Next Generation Materials. Analysis of Dr. Wickham's recent publications reveals a consistent focus on DNA nanotechnology with increasing sophistication in structural complexity and biological applications. Her work has evolved from fundamental DNA origami structures to increasingly complex multi-component systems with practical applications in nanomedicine and biomimetic engineering. Recent publications show strong interdisciplinary collaboration across chemistry, physics, biology, and engineering disciplines, with emphasis on real-world applications including drug delivery systems and biomolecular sensors. ARC DECRA Fellow Westpac Research Fellow BIOMOD World Champions (2019) Dr. Wickham actively mentors PhD students and postdoctoral researchers in her DNA nanotechnology group. She has secured significant research funding including ARC Discovery Projects, Westpac Scholarships, and NSW Health grants. Her current grants support projects such as '3D Bio-Nanomaterial Displays with Designer Architectures and Functions' and 'RNA aptamer sensing devices for rapid detection of blood clotting.' Dr. Wickham encourages applications from diverse backgrounds and maintains active collaborations with researchers at Harvard, Oxford, and other international institutions. Dr. Wickham leads the DNA Nanotechnology Group at the University of Sydney, which is part of the Sydney Nano Institute. Her lab focuses on building tools from DNA origami - including tweezers, spanners, wrenches and springs - to better understand biological processes at the nanoscale. The group has achieved notable success with the BIOMOD team winning world championships in 2019, and continues to develop innovative approaches to molecular robotics for healthcare applications.
