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Pei-Chung LeeView profile

Assistant Professor

• Host-pathogen interactions
• Innate immunity
• Microbiology/bacteriology
• +1 more

Pei-Chung Lee is an **Assistant Professor** in the Department of Biological Sciences at **Wayne State University (WSU)**, affiliated with the College of Liberal Arts and Sciences. His research focuses on host-pathogen interactions, particularly how bacterial pathogens like *Legionella pneumophila* exploit host cell mechanisms to cause disease. He employs multidisciplinary approaches to study innate immunity, post-translational modifications, and microbiology. Education: Ph.D., Case Western Reserve University (2011) Postdoctoral Scholar, Case Western Reserve University (2014) under Dr. Arne Rietsch Postdoctoral Fellow, NIH (2019) under Dr. Matthias Machner Research Interests: The lab investigates how pathogens manipulate host cell signaling (e.g., Hippo pathway) to evade immune responses. Key topics include bacterial effector kinases, inflammatory responses, and programmed cell death regulation in macrophages. Recent work highlights the role of Hippo kinases in controlling bacterial infections and sterile inflammation. Awards: Excellent in Teaching Award, College of Liberal Arts & Sciences, WSU (2024) Grants: R21 Grant (NIAID/NIH): Investigates Hippo kinases’ role in innate immunity Wayne State University Research Grant (2020–2021) Teaching:** Leads courses in infections, innate immunity, and microbiology, including BIO5310, BIO7610, and BIO2270. Encourages students from diverse backgrounds to join the lab for hands-on research. Lab Activities:** The lab actively recruits graduate and undergraduate students to explore host-pathogen interactions using cutting-edge techniques. Current projects aim to dissect molecular mechanisms of bacterial virulence and host defense pathways.

Andrew L SnowView profile

Professor

• Human Immunology
• Lymphocyte Signaling
• Apoptosis
• +3 more

Andrew L Snow, Ph.D. is a Professor at the Uniformed Services University of the Health Sciences (USU) in the School of Medicine and Department of Pharmacology & Molecular Therapeutics . His research focuses on human immunology, lymphocyte signaling, and primary immune disorders. Education B.S. in Biology and Visual Arts, Duke University Ph.D. in Immunology, Stanford University School of Medicine Postdoctoral Training, Laboratory of Immunology, NIAID, NIH Snow's work investigates genetic and molecular disruptions in antigen receptor pathways, particularly through CARD11 mutations causing BENTA and CADINS syndromes. His lab serves as a global referral center for validating CARD11 variants of unknown significance (VUS) in undiagnosed inborn errors of immunity (IEI) patients. Other key projects include studying restimulation-induced cell death (RICD) in T cells, especially in X-linked lymphoproliferative syndrome (XLP-1) where SAP deficiency impairs RICD sensitivity, and developing novel assays for KIT VUS validation in mast cell disorders. Recent publications highlight his contributions to understanding NF-κB and JNK signaling , immune dysregulation in IEIs, and the role of autoantibodies against type I IFNs in severe viral infections. His articles span immunology, genetics, and infectious disease research with specific subfields in lymphocyte apoptosis, genetic immunopathology, and metabolic reprogramming. Scientific Awards Outstanding Biomedical Graduate Educator Award (2022) Fellow of the Clinical Immunology Society (2021) Cinda Helke Award for Excellence in Graduate Student Advocacy (2017) Snow directs the Emerging Infectious Diseases Graduate Program at USU and collaborates with the Military Health System and American Genome Center on IEI patient sequencing. His lab employs advanced tools like spectral flow cytometry and scRNA-seq to identify therapeutic targets for immune homeostasis disorders.

Jennifer Bowen-ShauverView profile

Lecturer

• Cytokine Regulation in Reproductive Physiology
• Gestational Tissue Remodeling
• Molecular Endocrinology of Pregnancy
• +3 more

Dr. Jennifer Bowen-Shauver is a Lecturer in the Department of Biology at the University of the Incarnate Word. She holds a Ph.D. in Physiology from the University of Michigan (1999), an M.Sc. in Animal Physiology from Lincoln University, New Zealand (1994), and a B.S. in Animal Science from the University of Wyoming (1992). Her postdoctoral research spanned institutions including the University of Auckland and University of Illinois at Chicago, focusing on cytokine roles in gestational tissues. Research Focus: Dr. Bowen-Shauver investigates cytokine regulation and tissue remodeling in reproductive systems, particularly during pregnancy. Her work emphasizes prolactin’s role in programmed cell death and cytokine networks in placental tissues. Key areas include molecular endocrinology, placental biology, and immunological mechanisms influencing pregnancy outcomes. Publications: Her research spans molecular mechanisms underlying cytokine signaling in gestational tissues, with contributions to understanding SOCS proteins, interleukin-11 pathways, and activin regulation. Themes include preterm labor mechanisms, decidual apoptosis, and placental inflammation. Teaching: She teaches anatomy and physiology laboratory courses, contributing to foundational biology education at the undergraduate level.

• Molecular and Cellular Neurobiology
• Neurodegeneration
• Gene Expression
• +7 more

Prof. Joost Verhaagen is an Endowed Professor at the Faculty of Science, Vrije Universiteit Amsterdam, holding a joint appointment in the Amsterdam Neuroscience - Neurodegeneration program. His research focuses on molecular and cellular mechanisms underlying nervous system development, repair, and neurodegenerative diseases. He leads projects involving gene therapy, axonal regeneration, and neurotrophic factors. Education details are not explicitly stated in the provided texts, but his academic positions imply advanced training in neurobiology. Research interests include perineuronal nets, neural regeneration, Alzheimer’s resilience, and AAV vector applications. Recent articles emphasize novel findings in AAV toxicity, transcription factor roles in spinal cord repair, and gene expression patterns in Alzheimer’s resilient individuals. Prof. Verhaagen currently serves on editorial boards for Gene Therapy and Experimental Neurology , and advises organizations like the International Spinal Research Trust and End Paralysis Org. He has supervised 26 PhD theses but specific student names aren't listed here. Collaborations span institutions globally, focusing on neurodegeneration and regeneration. No labs/teams are explicitly named, but his work involves multidisciplinary teams in neuroscience and biotechnology.

• Veterinary Science
• Virology
• Animal Health
• +3 more

Dr Darren Miller is a Lecturer in the School of Animal and Veterinary Science at the University of Adelaide, within the Faculty of Sciences, Engineering and Technology. His research focuses on veterinary virology, infectious diseases, and immunological responses in livestock and wildlife. He is actively involved in supervising postgraduate students as a co-supervisor for Masters and PhD programs. Key research interests include: Bovine viral pathogens and their role in respiratory disease complexes Diagnostic methods for livestock viral infections Koala retrovirus (KoRV) epidemiology and vaccinology Development of novel drug delivery systems for gastrointestinal applications Molecular mechanisms of DNA vaccine efficacy enhancement Recent work highlights systematic reviews and meta-analyses of bovine viral diseases, including adenovirus, parainfluenza-3 virus, and respiratory syncytial virus. His studies also investigate innovative approaches such as recombinant protein vaccines for wildlife diseases and lentiviral gene transfer in non-human primates. Dr Miller has contributed to over 30 peer-reviewed publications since 2001, with a focus on virology, immunology, and veterinary medicine. His interdisciplinary approach bridges basic science and applied research in animal health.

• Cell Death
• Apoptosis
• Molecular Biology
• +3 more

Eric Gauthier serves as Full Professor and Director of the School of Natural Sciences at Laurentian University, based in Science Building Room F-422. He may be contacted via email at egauthier@laurentian.ca or telephone at 705.675.1151 extension 2119. His academic credentials include: B.Sc. in Biochemistry from Université du Québec à Trois-Rivières Ph.D. in Molecular and Cellular Biology from Université Laval Professor Gauthier's research program investigates molecular and cellular events in mammalian cell death with dual focus: Fundamental studies on L-glutamine-triggered intracellular survival signals, directly applicable to cancer research due to glutamine's critical role in tumor cell viability Applied research examining how modulating cell death pathways affects biotechnologically relevant cell lines His laboratory specializes in apoptosis mechanisms, stress kinase pathways, and nutrient deprivation responses using hybridoma cell models. He leads an active research team studying the regulation of late apoptotic events, with particular interest in proteins like Bcl-xL and GADD153 in cell culture systems. Their work bridges basic cell biology and therapeutic applications in oncology and bioprocessing.

Pradoldej SompolView profile

Assistant Professor

• Neuroscience
• Alzheimer's Disease Research
• Aging and Neurodegeneration
• +7 more

Pradoldej (Bob) Sompol, PhD, is an Assistant Professor at the Sanders-Brown Center on Aging, University of Kentucky. He is also affiliated with the Department of Pharmacology and Nutritional Sciences. His research focuses on understanding the role of reactive astrocytes in age-related neurodegenerative diseases, particularly Alzheimer’s disease. His research interests include: Reactive astrocytes and glial signaling Oxidative stress and mitochondrial dysfunction in neurodegeneration Neurovascular coupling and cerebrovascular pathology Calcineurin/NFAT signaling pathways Synaptic plasticity and network hyperexcitability Neuroprotective strategies using small molecules and natural compounds The recent publication trends highlight a strong focus on molecular mechanisms in Alzheimer’s and traumatic brain injury models, with particular emphasis on astrocyte-mediated neuroinflammation, synaptic dysfunction, and therapeutic interventions targeting neuroprotection and neurogenesis. Techniques such as intravital imaging, electrophysiology, and behavioral assays are central to his research approach. Scientific awards: No awards explicitly mentioned in the provided text. Dr. Sompol actively leads a research program investigating neurodegenerative mechanisms using human postmortem tissue and transgenic animal models. While specific student mentees are not listed, his publications suggest collaborative mentoring in neuroscience and pharmacology. His lab has developed innovative models combining vascular and amyloid pathologies, contributing to a deeper understanding of mixed dementia etiologies. There is no mention of external grants, but his work implies funding support for advanced imaging and molecular studies. His research team operates within the Sanders-Brown Center on Aging, a leading institution in aging and dementia research, and collaborates extensively across disciplines, particularly in pharmacology and neuroscience.

Gregory J. GoresView profile

Professor

• Apoptosis
• Liver Cell Death Mechanisms
• Cholestatic Liver Diseases
• +6 more

Gregory J. Gores, M.D. is a Professor of Medicine and Professor of Physiology at the Mayo Clinic . His research focuses on liver cell death mechanisms, particularly apoptosis , and cancer cell escape in hepatobiliary diseases . Education: MD, University of North Dakota BS in Medicine and Natural Science (Summa Cum Laude), University of North Dakota Residency: Mayo Clinic College of Medicine Research Interests include cholestatic liver diseases , fatty liver diseases , and malignant transformation in bile duct cancers. He develops disease-relevant models to study cellular processes. Scientific Awards include: Professional Achievement Award (2023) Best Doctors in America (2005-2013) Distinguished Investigator Award (2008) His clinical research involves innovative protocols for hepatocellular carcinoma and cholangiocarcinoma . He leads grants on macrophage biology , cell signaling , and epigenetic regulation .

Adrian ZającView profile

Assistant Professor

• Cancer Biology
• Apoptosis
• Cell Signaling
• +4 more

Dr. Adrian Zając is an Assistant Professor at the Department of Functional Anatomy and Cytobiology within the Faculty of Biology and Biotechnology at Maria Curie-Skłodowska University (UMCS) in Lublin, Poland. His academic career focuses on cancer biology, particularly the investigation of molecular mechanisms involved in programmed cell death in glioma cells. Dr. Zając received his PhD in 2020 with a dissertation titled "Temozolomide and inhibitors of pathways dependent on the TrkB receptor in the induction of programmed death of human glioma cells in vitro." His research expertise spans cell biology techniques including morphological identification of cell death types, cell migration assays, immunocytochemistry, cell cultures, light, fluorescent and electron microscopy, and flow cytometry. He also possesses extensive skills in molecular biology methods such as protein and nucleic acid electrophoresis, immunoblotting, immunoprecipitation, and gene expression silencing using siRNA. Dr. Zając's research primarily investigates the impact of natural compounds and their synthetic derivatives on inhibiting intracellular survival pathways and inducing programmed cell death in human tumor cells. His work focuses on analyzing molecular mechanisms of elimination of transformed cells through apoptosis and autophagy, with particular emphasis on brain tumors. He has made significant contributions to understanding signaling pathways regulating migration, invasion, and metastasis of brain tumor cells, as well as the correlations between proteins regulating apoptosis and autophagy in glioma cells. His recent publication portfolio demonstrates a strong focus on glioma research, with particular attention to the PI3K-Akt/PKB-mTOR and Ras-Raf-MEK-ERK intracellular survival pathways. Dr. Zając frequently investigates natural compounds such as furanocoumarins, osthole, and plant extracts for their potential to enhance conventional anticancer therapies. His work bridges plant biochemistry with cancer therapeutics, exploring how natural substances can sensitize glioma cells to programmed cell death. 2014 - Scholarship of the Minister of Science and Higher Education for outstanding achievements 2018 - Prof. Bolesław Skarżyński Award for the best article in Postępy Biochemii 2021 - Rector's Award for a highly scored scientific article 2022 - Rector's Award for a highly scored scientific article Dr. Zając has successfully led research projects, including the 2021 project "Evaluation of the involvement of the Bcl-2 and beclin-1 protein complex in the elimination of glioma cells through programmed cell death" (PB-X-11-532-21) funded by the National Science Centre under the MINIATURA 5 program. Beyond his research, he actively participates in scientific community building as Secretary of the Lublin Branch of the Polish Biochemical Society and as a member of the Federation of European Biochemical Societies. His commitment to education is evident through his organization of numerous conferences, participation in Open Doors events, Biology Night, and Lublin Science Festival, as well as conducting educational workshops for schools.

Benjamin BardiauxView profile

Researcher

• Structural Bioinformatics
• Nuclear Magnetic Resonance (NMR)
• Integrative Structural Biology
• +7 more

Benjamin Bardiaux is a permanent research associate at CNRS UMR3528 within the Structural Bioinformatics Unit at the Institut Pasteur in Paris, affiliated with the Department of Structural Biology and Chemistry. He has been actively contributing to research since December 2012, focusing on integrative and computational structural biology with applications in bacterial pathogenesis and membrane systems. His research interests include Structural Bioinformatics, Nuclear Magnetic Resonance (NMR), Molecular Dynamics, Hybrid Structure Determination, Bacterial Transmembrane Systems, and Protein Structure Analysis . His work integrates computational modeling with experimental data to understand the dynamics and function of complex biomolecular systems, particularly in Gram-negative bacteria. The recent publications highlight a strong trend in integrative structural biology , combining NMR, cryo-EM, and molecular dynamics to study bacterial secretion systems, nutrient transporters, and protein fibrils. There is a growing emphasis on AI and big data in structural modeling, reflected in his involvement in workshops on AI for 3D structure prediction. His research spans from atomic-resolution structures to functional mechanisms in bacterial envelopes. Benjamin Bardiaux leads the ARIA-based projects, including the ARIAweb server for automated NMR structure calculation and cloud-based hybrid structure determination. He collaborates extensively with leading scientists such as Michael Nilges, Nadia Izadi-Pruneyre, and Olivera Francetic. He actively contributes to education and training, serving as an instructor in AI-focused workshops for PhD students at the Institut Pasteur. His participation in seminars and conferences underscores his engagement with the structural biology community.

Ragnhild Elisabeth Heimtun PaulsenView profile

Professor

• Pharmacology
• Neurobiology
• Neurotoxicology
• +4 more

Ragnhild Elisabeth Heimtun Paulsen serves as Professor in the Department of Pharmacy at the University of Oslo's School of Pharmacy, where she has held academic positions since 1985. She currently leads the Section for Pharmacology and Pharmaceutical Biosciences (2021-2024) and maintains an active research program focused on molecular mechanisms of neurodevelopment and cell death in the central nervous system. Her primary research interests span Pharmacology, Neurobiology, Neurotoxicology, and Molecular Neurobiology, with specific focus on neurodevelopmental disorders, brain stroke, and epilepsy. Early in her career, she investigated astroglial functions, while her more recent work concentrates on brain receptors and their roles in neurodevelopment and cell death pathways. She has pioneered the use of chicken embryo as an alternative, 3R-compliant animal model for studying medication and environmental pollutant effects on neurodevelopment. Analysis of her recent publications reveals a consistent research trajectory examining neurotoxic mechanisms through innovative model systems, particularly the chicken embryo model. Her work bridges pharmacology, neuroscience, and toxicology with emphasis on developmental neurotoxicity, receptor pharmacology, and molecular mechanisms of cell death. The publications demonstrate strong international collaboration across multiple institutions. Professor Paulsen teaches FARM3110 – Pharmacotherapy 2 and Physiology 3, and FARM5170 – Drugs for treatment of degenerative and lifestyle diseases at the University of Oslo. She has served in significant leadership roles including Secretary and President of the Norwegian Neuroscience Society (1997-2014) and as elected member of the Department Board (2013-2016). Her research is conducted through the Neurobiology & Toxicology and PharmaTox research groups, with collaborations extending to other departments within the Faculty of Pharmacy, the Department Group for Basic Medical Sciences at OUS, the Norwegian Institute of Public Health, and multiple international partners as reflected in her publication record.

• Mitochondrial Metabolism
• Cellular Metabolism
• Cancer Biology
• +3 more

Jessica Brooke Spinelli is an Assistant Professor at the UMass Chan Medical School within the Program in Molecular Medicine . She holds multiple affiliations across Morningside Graduate School of Biomedical Sciences departments including Biochemistry and Molecular Biotechnology, Cancer Biology, and Translational Science. BSc in Biochemistry from Hofstra University PhD in Chemical Biology from Harvard University Her research focuses on mitochondrial metabolism and its role in cellular decision-making. Key areas include: Metabolic reprogramming in obesity and cancer Redox homeostasis and stress survival Electron transport chain dynamics Lipid-metabolism interactions Thermogenesis in adipose tissues Metabolic vulnerabilities in disease states Recent publications (2023-2025) highlight her work on: Rhodoquinone's role in mammalian electron transport Sex-specific metabolic enzyme phosphorylation in obesity MCJ/DnaJC15's influence on brown fat thermogenesis Glucose-pyrimidine interdependencies in cancer Ammonia recycling mechanisms in tumor growth Selenium-ubiquinone interactions in ferroptosis She collaborates extensively with researchers in: Molecular Medicine Biochemistry Cancer Biology Metabolic Disease

• Biochemistry
• Molecular Biology
• Mitochondrial Metabolism
• +6 more

Jorge Sastre Serra is a Full Professor in the Department of Biochemistry and Molecular Biology within the Department of Fundamental Biology and Health Sciences at the University of the Balearic Islands (UIB). He has been serving in this role since April 2022, following prior appointments as Interim Contracted Doctor Professor (2019–2022), Assistant Professor Doctor (2018–2019), and Associate Professor (2015–2018). He is also the Secretary of the department and a member of the Multidisciplinary Group of Translational Oncology (GMOT) at IUNICS and IdISBa. Degree in Biology, University of the Balearic Islands (2007) Degree in Biochemistry, University of the Balearic Islands (2007) PhD in Biochemistry and Molecular Biology, University of the Balearic Islands (2012) His research focuses on mitochondrial metabolism and oxidative stress in cancer , particularly examining the role of estrogen receptors in mitochondrial dynamics, biogenesis, and their implications in oncogenesis. His work spans molecular mechanisms of redox balance, metabolic reprogramming in tumors, and translational applications for cancer therapy. The most recent publications reflect a strong focus on mitochondrial biology in cancer, with recurring themes including mitochondrial fission/fusion, estrogen receptor signaling, oxidative stress pathways, and their integration into translational oncology. Articles emphasize both mechanistic insights and clinical relevance, demonstrating a consistent trajectory toward understanding cancer metabolism and identifying novel therapeutic targets. 2 teaching quinquennia recognized 2 research sexennia (2007–2015 and 2016–2021) Remuneration supplements for teaching excellence and permanent training Remuneration supplements for research activity and excellence Remuneration supplements for knowledge transfer Jorge Sastre Serra has participated in 29 national and local research projects, serving as Principal Investigator in 6 of them. He also acts as co-Investigator in 4 fundraising projects coordinated by FUEIB or IdISBa, highlighting his active engagement in securing research funding and collaborative science. He teaches in both undergraduate (Biochemistry, Molecular Biology) and postgraduate (Biomedical Research Master’s) programs and supervises Master's and Bachelor's theses, as well as doctoral students in Translational Research and Food Sciences programs. His primary research is conducted within the Multidisciplinary Group of Translational Oncology (GMOT) , a consolidated R&D group affiliated with IUNICS and IdISBa, which fosters interdisciplinary collaboration between basic scientists and clinicians to advance cancer research from bench to bedside.

• Data Science
• Machine Learning
• Deep Learning
• +5 more

Prof. Dr. Jana Schor is a leading academic in Data Science at the University of Leipzig , holding the Professorship for Bio-Data Science under its Faculty of Mathematics and Computer Science . She is also the Head of the Bio-Data Science Group at the Helmholtz Centre for Environmental Research (UFZ) , where her work bridges Computational Biology , Environmental Health , and Toxicology . Focus areas: Statistical Learning , Graph Neural Networks , Explainable AI , and Environmental Data Infrastructure Academic leadership: Teaching courses in Data Science , R Programming , and Reproducible Research at the University of Leipzig Her research emphasizes AI-driven hypothesis generation , domain-specific knowledge graphs , and uncertainty quantification in predictive models . Recent projects involve toxicity prediction across chemical spaces ( deepFPlearn+ ), chemical grouping frameworks , and PFAS exposure analysis using zebrafish models . She actively contributes to open science through tools like CleanGeoStreamR and Neo4j datasets .

Sally KornbluthView profile

Professor

• Cell Biology
• Apoptosis Regulation
• Cancer Biology
• +3 more

Sally Kornbluth is the President of MIT and a Professor of Biology at the Massachusetts Institute of Technology. She previously served as Provost of Duke University (2014–2022) and Vice Dean for Basic Sciences at Duke University School of Medicine (2006–2014). Her research focuses on cellular mechanisms governing cell division and programmed cell death (apoptosis), with particular emphasis on cancer biology and metabolic regulation of apoptosis. She has made significant contributions to understanding how cancer cells evade apoptosis and how metabolic pathways influence cell death processes. Education: PhD in Biology, Rockefeller University (1989) BA in Political Science, Williams College (1982) BS in Genetics, University of Cambridge (1984) Research Interests: Kornbluth’s work explores the interplay between metabolism and apoptosis, including roles in cancer resistance, female fertility regulation, and degenerative disorders. Her studies on caspase-2 activation and metabolic signaling have revealed critical mechanisms for therapeutic intervention in conditions like non-alcoholic steatohepatitis and ovarian cancer. Awards and Honors: Member, American Academy of Arts and Sciences (2020) Member, National Academy of Inventors (2018) Member, National Academy of Medicine (2013) Distinguished Faculty Award, Duke Medical Alumni Association (2013) Administrative Leadership: As MIT President, she oversees institutional strategy and innovation in education/research. Previously, she led Duke’s basic science initiatives and medical education reforms, emphasizing translational research and faculty development. Labs/Teams: While her current role is administrative, her prior lab at Duke investigated apoptosis regulation in vertebrate systems. Collaborations span cancer biology, reproductive science, and metabolic disorders.