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Struan F.A. GrantView profile

Professor

• Human Genetics
• Pediatric Genomics
• Endocrinology
• +5 more

Struan F.A. Grant is a distinguished Professor of Pediatrics (Human Genetics) at the University of Pennsylvania and a Professor of Genetics at the Perelman School of Medicine. He holds the Daniel B. Burke Endowed Chair for Diabetes Research and serves as Director of the Center for Spatial and Functional Genomics at Children's Hospital of Philadelphia (CHOP). His work bridges human genetics with pediatric disease genomics, focusing on obesity, diabetes, and bone disorders. Current affiliations: UPenn, CHOP Graduate group affiliations: Cell and Molecular Biology, Genomics and Computational Biology Research Focus : With over 25 years of experience, Grant's career highlights include discovering the COL1A1 polymorphic Sp1 site linked to osteoporosis and the TCF7L2 gene's role in type 2 diabetes. His current work leverages high-throughput genomics and bioinformatics to unravel pediatric disease mechanisms, particularly in obesity and metabolic disorders where genetic factors are more discernible due to limited environmental exposure. Scientific Awards : Wellcome Postdoctoral Fellowship Daniel B. Burke Endowed Chair for Diabetes Research Advising & Funding : Mentored numerous trainees including Max F. Dudek and Elizabeth A. Burton. Active funding includes grants from NIH (R01 HD056465, R01 HD100406, R01 AG072705, UM1 DK126194) and co-investigator roles in R01 NS135075, R01 AI154773, and P01 HL160471.

Benjamin WolozinView profile

Professor

• Neurodegenerative Diseases
• Alzheimer's Disease
• Parkinson's Disease
• +7 more

Benjamin Wolozin is a Professor at the Boston University Chobanian & Avedisian School of Medicine in the Department of Pharmacology , with an adjunct position in Neurology. He specializes in neurodegenerative diseases, particularly Alzheimer's , Parkinson's , and ALS . MD/PhD, Albert Einstein College of Medicine Past Associate Professor at Loyola University Medical Center (1996-2004) Current affiliations: Alzheimer's Disease Center, Boston University Graduate Program for Neuroscience His research investigates RNA binding proteins (RBPs) , stress granules , and liquid-liquid phase separation in neurodegenerative disease. Key projects include the role of TIA1 and HNRNPA2B1 in tauopathy, m6A RNA methylation in Alzheimer's pathology, and development of 3D iPS-neuron/astrocyte assembloids to model dementia. His lab has identified disease-linked circRNA changes and explores nanobodies targeting stress granule components. Recent awards include the Donald B. Lindsley Prize (Society for Neuroscience) and A. E. Bennett Award . He serves on NIH CDIN study sections and editorial boards for Journal of Biological Chemistry and Neurodegenerative Diseases . Grants include multiple NIH R01 and U01 awards for AD/tauopathy research.

Paul R. AdamsView profile

Professor

• Computational Neuroscience
• Theoretical Neuroscience
• Synaptic Plasticity
• +3 more

Paul R. Adams is a Professor in the Department of Neurobiology and Behavior at Stony Brook University's Renaissance School of Medicine. He joined Stony Brook in 1981 as an Associate Professor and was promoted to Professor in 1984, following prior faculty service at the University of Texas (1977-1981). His educational background includes a B.A. in Physiology and Pharmacology from Cambridge University (1968) and a Ph.D. in Pharmacology from London University (1974). Professor Adams' research centers on computational neuroscience , investigating how synaptic modifications underlying learning are compromised by crosstalk between densely packed synapses. His pioneering Synaptic Darwinism theory proposes evolutionary mechanisms for cortical learning, including "Hebbian proofreading" where layer 6 neurons detect and correct learning errors. He further explores how inter-brain communication networks overcome individual learning failures through information sharing. His publication trajectory reveals consistent focus on mathematical modeling of neural plasticity, evolving from foundational Synaptic Darwinism concepts (1997-2002) to recent work on crosstalk minimization (2013-2014). Key themes include Hebbian learning constraints, cortical circuitry reinterpretation, and theoretical solutions to neural network limitations. Notable honors include the MacArthur Foundation Prize (1986), election as Fellow of the Royal Society (1991), and Howard Hughes Medical Institute Investigatorship (1987-1995). Professor Adams leads theoretical neuroscience research through the Kalypso Mind/Brain Center, collaborating with Research Assistant Professor Kingsley Cox. His HHMI-funded work has influenced understanding of cortical function relevant to autism, schizophrenia, and epilepsy. He serves on editorial boards including Frontiers in Neural Circuits . The Synaptic Darwinism project maintains active investigation into cerebral cortex principles, exploring implications for both neurological disorders and fundamental questions about consciousness.

Ye Emily WuView profile

Assistant Professor

• Neurobiology
• Molecular Neuroscience
• Computational Neuroscience
• +6 more

Ye Emily Wu, Ph.D., is an Assistant Professor jointly appointed in the Department of Neurobiology and Department of Biological Chemistry at the David Geffen School of Medicine, University of California, Los Angeles (UCLA). She leads an integrative research program combining molecular, circuit, and computational neuroscience to understand affiliative social behavior and its disruption in neurodevelopmental and neuropsychiatric disorders. Education: Ph.D. from Stanford University Postdoctoral training at University of California, Los Angeles Research Interests: Dr. Wu's research focuses on elucidating the molecular, cellular, and circuit mechanisms that govern social behavior. Her work spans genetics, bioinformatics, behavioral neuroscience, and computational modeling. She investigates how disruptions in these systems contribute to social deficits in autism and other neuropsychiatric conditions. Her recent work emphasizes the use of single-cell transcriptomics, calcium imaging, and behavioral paradigms to map brain activity to specific cell populations and understand prosocial behavior. Her research integrates cutting-edge techniques such as in vivo calcium imaging, optogenetics, and machine learning to dissect the neural circuits underlying empathy, parenting, and affiliative touch. This multidisciplinary approach allows her to bridge molecular insights with behavioral outcomes. Scientific Awards: No specific awards are listed in the provided text. Advising and Grants: While no specific students or grants are listed, her research program is clearly supported by active funding and includes mentoring roles within UCLA’s neuroscience community. Labs and Teams: Dr. Wu leads a research group at UCLA that collaborates across departments and uses advanced technologies to study neural circuits and social behavior. Her lab is affiliated with both the Department of Neurobiology and the Department of Biological Chemistry, reflecting her interdisciplinary expertise.

Natalie TronsonView profile

Associate Professor

• Neuroscience
• Psychology
• Behavioral Neuroscience
• +5 more

Natalie Tronson, Ph.D. is an Associate Professor in the Department of Psychology at the University of Michigan. Her research explores sex differences in aversive memory mechanisms and the role of immune signaling in long-term cognitive and affective changes. BSc: University of New South Wales PhD: Yale University Postdoctoral Fellowship: Asher Center for the Study and Treatment of Depressive Disorders, Northwestern University Dr. Tronson's research bridges Neuroscience , Psychology , and Neuroimmunology , focusing on hormonal influences and inflammation in memory, stress, and mental health. Recent work highlights hormonal contraceptives and neuroimmune activation in shaping cognitive vulnerabilities. Her lab employs non-human animal models to investigate trauma/stress-related disorders , sex-specific neurobiological mechanisms, and translational implications for mental health.

Qunzhou ZhangView profile

Academic

• Regenerative medicine
• Mesenchymal stem cell biology
• Immunomodulation and anti-inflammation
• +4 more

Dr. Qunzhou Zhang, PhD, is a Research Assistant Professor in the Department of Oral and Maxillofacial Surgery / Pharmacology at the University of Pennsylvania School of Dental Medicine , Philadelphia, USA, where he has held successive appointments since 2012. He also maintains adjunct/visiting professor affiliations with Guangdong Medical University in China (2008–2016). He earned his doctoral degree in Biochemistry & Molecular Biology from West China University of Medical Sciences (now Sichuan University) in 2000, preceded by an M.Sc. from Guangdong Medical University (1997) and a B.A. in Preventive Medical Sciences from Chongqing Medical College (1990). Dr. Zhang’s research program sits at the intersection of regenerative medicine, stem cell biology, immunomodulation, and cancer . His laboratory focuses on: Immunomodulatory and anti-inflammatory functions of gingiva-derived mesenchymal stem cells (GMSCs) in rodent models of colitis, skin/oral wounds, and allergic dermatitis. Non-genetic induction of neural crest stem-like cells (NCSC) from GMSCs for peripheral nerve regeneration, including 3D bioprinted, scaffold-free nerve grafts . Paracrine mechanisms involving extracellular vesicles (exosomes) secreted by GMSCs that modulate host tissue microenvironments and promote tongue muscle/taste-bud regeneration. Tumor microenvironment studies exploring how mesenchymal stromal cells influence the pathogenesis of ameloblastoma and head & neck squamous cell carcinoma (HNSCC) . Across 50+ peer-reviewed publications since 2004, his work demonstrates a consistent trajectory from basic mechanistic studies to translation-oriented tissue engineering , with particular emphasis on exosome-based therapies and 3D bioprinting technologies . Scientific Awards & Honors Research Support Grant (RSG) , Oral and Maxillofacial Surgery Foundation (2008, 2011, 2014, 2017) Pilot Research Grant , University of Pennsylvania Diabetes Research Center Peter Geistlich Research Award , OsteoScience Foundation (2016) Honored/Adjunct Professor , Guangdong Medical University (2008–2016) Dr. Zhang has served as ad-hoc peer reviewer for more than 25 high-impact journals, including J Invest Dermatol, Stem Cells & Development, Tissue Engineering, PLOS ONE, J Dental Res, Oncotarget and others. While the provided text does not list specific PhD or Master’s students, his role as senior investigator and lab manager implies active mentoring within the university’s research programs. His laboratory is located within the Department of Oral & Maxillofacial Surgery & Pharmacology at Penn Dental Medicine, equipped for in vivo rodent surgery, stem cell culture, 3D bioprinting, and molecular profiling . Future directions include first-in-human trials of GMSC-derived exosome therapeutics and scale-up manufacturing of 3D bioprinted nerve constructs.

• Structural Biology
• Computational Biology
• Molecular Biophysics
• +4 more

Bojan Zagrovic is a Professor at the Department of Structural and Computational Biology , University of Vienna. His research focuses on the interplay between protein structure, RNA interactions, and molecular dynamics, particularly in phase separation, enzyme mechanisms, and disease-related mutations. Key research areas: Structural Biology, Computational Biophysics, RNA-Protein Interactions, Phase Separation, and Protein Aggregation. Recent work includes studying FUS RGG3 phase separation, α-mannosidase pathophysiology, and SPOC domain interactions. His publications span molecular dynamics simulations, RNA modifications (e.g., N6-methyladenosine), and structural insights into ciliary proteins like CFAP410. He teaches courses in computational structural biology, molecular biophysics, and quantitative biology.

David I. YuleView profile

Professor

• Intracellular Calcium Signaling
• Exocrine Cell Physiology
• Signal Transduction
• +3 more

David I. Yule, Ph.D., is a Professor at the University of Rochester School of Medicine and Dentistry , holding dual appointments in the Department of Pharmacology and Physiology and the Department of Medicine, Gastroenterology/Hepatology . His research focuses on intracellular calcium signaling in exocrine cells , particularly pancreatic acinar cells and salivary gland cells , investigating how IP3 receptors and ryanodine receptors regulate fluid secretion , enzyme release , and pathophysiological responses in diseases like acute pancreatitis and Sjögren's Syndrome . Ph.D., University of Liverpool (1989) B.S., Portsmouth Polytechnic (1985) Postdoctoral work: MRC Secretory Control Group, University of Liverpool and University of Michigan Yule's lab employs high-speed confocal microscopy , antisense technology , and fluorescence imaging to dissect agonist-specific signaling pathways and calcium release site organization . Current projects include studying IP3 receptor phosphorylation , genetic defects in calcium signaling linked to dry mouth diseases, and mitochondrial interactions in calcium dynamics. His recent 15 most influential publications span topics from IP3R isoform regulation in gluconeogenesis to calcium oscillation modeling and Bcl-2 family modulation of apoptotic signaling . Collaborative work with institutions like Stanford and KU Leuven has produced key insights into organellar calcium channels . Recipient of the Louis C. Lasagna Professorship in Experimental Therapeutics (2016) Awarded with the 2016 Convocation Award at University of Rochester As mentor, Yule supervises graduate students in multidisciplinary research, including projects on radiation-induced salivary dysfunction (Amanda Wahl, NIH F31 awardee) and mitochondrial Ca²⁺ handling . His lab maintains a 3D computational modeling partnership with J. Sneyd to integrate experimental data with theoretical frameworks.

Kathy IovineView profile

Professor

• Developmental Biology
• Regeneration
• Skeletal Morphogenesis
• +4 more

Kathy Iovine serves as Professor and Department Chair at Lehigh University, leading research in skeletal development and regeneration using zebrafish models. Her work focuses on elucidating molecular mechanisms controlling bone growth through fin regeneration studies. Her primary research interests span developmental biology, regeneration, skeletal morphogenesis, cell-cell communication, and extracellular matrix dynamics. She investigates how connexin43 (Cx43)-mediated gap junctional communication coordinates skeletal growth and patterning, with emphasis on segment addition in zebrafish fins as the fundamental unit of bone growth. Key areas include semaphorin signaling, hyaluronic acid metabolism, and collagen-based actinotrichia structures. Analysis of her publication record reveals consistent exploration of Cx43-dependent networks across 15+ recent studies. Her work demonstrates how mutations in connexin43 disrupt fin length regulation through effects on cell proliferation and joint formation, identifying critical mediators like Sema3d and Hapln1a. The research integrates genetic, molecular, and cellular approaches to dissect pathways governing skeletal morphogenesis. Dr. Iovine directs an active research laboratory investigating the genetic basis of skeletal development. Her team has characterized how actinotrichia integrity signals between proliferating and differentiating cell compartments to coordinate growth, and how Cx43 regulates extracellular environment modifiers. Current efforts focus on validating additional genes within the Cx43-dependent network to uncover novel therapeutic targets for skeletal disorders.

Artur LuczakView profile

Professor

• Computational Neuroscience
• Neural Coding
• Cortical Dynamics
• +2 more

Artur Luczak is a Professor of Neuroscience at the University of Lethbridge, where he has been a faculty member since 2009 and is affiliated with the Canadian Centre for Behavioural Neuroscience (CCBN). His research integrates experimental and theoretical approaches to study cortical dynamics and neural computation. PhD from Jagiellonian University, Poland MSc from Wroclaw University of Technology Dr. Luczak's research focuses on how neuronal populations process information through spontaneous and sensory-evoked activity. Key interests include metabolic constraints on neural coding, predictive processing in cortical networks, and the role of neural sequences in brain function. His work bridges computational modeling with electrophysiological data to uncover fundamental principles of neural organization. His publications from 2007-2022 reveal consistent exploration of spontaneous cortical activity patterns, with increasing emphasis on energy efficiency and machine learning-inspired neural algorithms. The 2022 Nature Machine Intelligence paper demonstrating how neurons optimize metabolic energy through activity prediction represents a paradigm shift in understanding neural learning mechanisms. Scientific Awards: Fellowship in the Netherlands Fellowship in France Fellowship in Italy Dr. Luczak has trained graduate students and postdoctoral fellows through CCBN's neuroscience programs, with research supported by national and international grants. His teaching portfolio includes computational neuroscience workshops, MATLAB programming courses, and core neuroscience curriculum. He leads a research group at the CCBN utilizing multidisciplinary approaches including in vivo electrophysiology, computational modeling, and behavioral analysis to investigate neural dynamics across multiple scales.

Lorraine IacovittiView profile

Professor

• Neurodegenerative Diseases
• Stem Cells
• Parkinson's Disease
• +2 more

Lorraine Iacovitti is a Professor in the Department of Neuroscience at Thomas Jefferson University, affiliated with the Vickie and Jack Farber Institute for Neuroscience and the Jefferson Stem Cell & Regenerative Neuroscience Center. Her research focuses on developing cell-based therapies for neurodegenerative disorders through stem cell differentiation studies. Her educational background includes: Post-Doctoral, Washington University-St. Louis, Anatomy & Neurobiology (1981) PhD in Neurobiology from Cornell University Medical College (1979) BS in Biology from Monmouth College (1973) Dr. Iacovitti's laboratory investigates dopamine neuron development to create molecular blueprints for treating Parkinson's disease. Using human embryonic stem cells and precursor cells, her team employs a multidisciplinary approach combining tissue culture, molecular engineering (qPCR, microarray, transfection), anatomical analysis (immunocytochemistry, confocal microscopy), biochemical assays (HPLC), stereotaxic surgery, and behavioral testing in rodent models. Current work focuses on inducing dopaminergic traits in stem cells and optimizing transplantation protocols for Parkinson's disease models. Recent publications demonstrate consistent translational focus on stem cell applications for neurological conditions, particularly stroke recovery and Parkinson's disease. Key themes include extracellular vesicle therapeutics, molecular pathways protecting dopaminergic neurons, and motor function restoration in animal models of ischemic injury. Dr. Iacovitti leads an active research laboratory within the Vickie and Jack Farber Institute for Neuroscience, utilizing advanced techniques including PET/SPECT imaging, arterial occlusion surgery, and comprehensive behavioral assessment. Her work bridges basic developmental neuroscience with preclinical cell therapy development for neurodegenerative conditions.

• Adult neurogenesis
• Structural plasticity
• Neural stem cells
• +4 more

Prof. Dr. Gerd Kempermann serves as Group Leader and Site Speaker at the German Center for Neurodegenerative Diseases (DZNE) in Dresden, with parallel research activities at the Center for Regenerative Therapies Dresden (CRTD). His work bridges fundamental neuroscience with clinical applications for neurodegenerative conditions. His research focuses on adult neurogenesis in the hippocampus, examining how new neurons integrate into existing neural networks to provide cognitive flexibility, particularly in memory formation and context integration. Kempermann's work has established the concept of a 'neurogenic reserve' that can be built through physical and cognitive activity to counteract age-related cognitive decline. His laboratory operates across two complementary sites with three specialized research pillars: Stem cell models: Developing advanced neural stem cell cultures from adult mouse and human hippocampus by combining classical cell culture techniques with modern biomaterials Epigenetics: Investigating how activity patterns induce lasting changes in neural stem cell behavior through epigenetic mechanisms Human translation: Developing methods to assess neurogenesis-related functions in humans, including patients with neurodegenerative diseases Kempermann's research has significant implications for understanding dementia, depression, and other conditions where hippocampal function is compromised.

Benjamin RostView profile

Researcher

• Optogenetics
• Neuroscience
• Synaptic Plasticity
• +3 more

Dr. Benjamin Rost is a researcher at the Institute of Neurophysiology within the Faculty of Medicine at Charité - Universitätsmedizin Berlin. He is a core member of Collaborative Research Center SFB 1315 (Project C01), focused on developing molecular tools for memory engram manipulation and investigation. His research centers on optogenetic technology development and neural circuit analysis, with specific expertise in synaptic plasticity mechanisms, calcium signaling control, and neuromuscular junction modeling. Key contributions include engineering calcium-permeable channelrhodopsins (CapChRs) for precise intracellular signaling manipulation, developing bistable opto-GPCRs like PdCO for multiplexed circuit interrogation, and creating self-organizing neuromuscular junction models from human stem cells. His work bridges molecular engineering, electrophysiology, and disease modeling to address fundamental questions in neural communication. Recent publications reveal a clear trajectory toward increasingly sophisticated optogenetic tools with enhanced spatiotemporal precision. His 2022-2025 work demonstrates progression from foundational presynaptic optogenetics (2022) to asymmetric plasticity discovery (2025), with critical intermediate advances in calcium signaling (2022), stem cell-based disease models (2023), and high-throughput screening systems (2024). This evolution highlights his interdisciplinary approach combining biophysics, stem cell biology, and circuit neuroscience. Dr. Rost operates within Prof. Dietmar Schmitz's laboratory at Charité's Institute of Neurophysiology, leveraging SFB 1315 resources for memory engram research. His team employs advanced techniques including patch-clamp electrophysiology, stem cell differentiation protocols, and custom-built optogenetic hardware like the RainbowCap illumination system for microplate-based assays.

• Machine Learning Theory
• Statistical Physics
• Neuroscience
• +5 more

Stefano Sarao Mannelli is a tenure-track Assistant Professor in the Department of Computer Science and Engineering at Chalmers University of Technology and University of Gothenburg. He also holds a Visiting Lecturer position at the University of the Witwatersrand. His research group focuses on fundamental aspects of learning in biological and artificial systems, with emphasis on bias generation, optimization dynamics, and comparative neuroscience. Education: Ph.D. in Theoretical Physics, Université Paris-Saclay (2020) M.Sc. in Electronic Engineering, Politecnico di Torino (2017) M.Sc. in Physics of Complex Systems, Politecnico di Torino/SISSA (2016) M2 in Physique Théorique, Paris Diderot/UPMC/ENS Cachan (2016) B.Sc. in Mathematics for Engineering, Politecnico di Torino (2014) Research: Dr. Mannelli develops model-based approaches to reduce complex machine learning problems into analytically tractable frameworks. His core interests include: 1) Bias amplification mechanisms in AI systems, 2) Learning differences between biological and artificial neural networks (continual/transfer/curriculum learning), and 3) Optimization in high-dimensional landscapes. His work bridges statistical physics, neuroscience, and deep learning theory. Publication Trends: Recent articles (2024-2025) predominantly analyze curriculum learning dynamics, bias propagation in optimization, and theoretical comparisons between biological and artificial learning systems. Methodologically, they combine statistical physics frameworks with control theory and high-dimensional analysis. Awards: Academic Grant (CM Lerici Foundation, 2025) Travel Grants (Guarantor of Brains, G-Research 2024) UK–IT Trustworthy AI Exchange Programme (Alan Turing Institute, 2023) SCGB Conference Award (Simons Foundation, 2023) Ph.D. Scholarship (CEA, 2017-2020) Team & Funding: Leads a research group with 2 PhD students and 1 postdoc. Secured significant funding for international workshops including Analytical Connectionism (£42K, 2023; $152K, 2024) and High-Dimensional Methods (135,500 SEK, 2025).

Wei CaoView profile

Professor

• Neuroinflammation
• Alzheimer's Disease
• Neurodegenerative Diseases
• +7 more

Dr. Wei Cao is a Professor at The University of Texas Health Science Center at Houston conducting groundbreaking research at the intersection of neuroscience and immunology. His work focuses on neuroinflammation in neurodegenerative diseases, particularly Alzheimer's disease, with emphasis on the role of type I interferon pathways and microglial activation in disease pathogenesis. Dr. Cao's educational background includes a BS equivalent in Biological Science from Tsinghua University, a PhD in Biochemistry from the University of North Carolina at Chapel Hill, and postdoctoral training in Molecular Virology at The Scripps Research Institute. BS (eq) in Biological Science - Tsinghua University, Beijing, China PhD in Biochemistry - University of North Carolina at Chapel Hill Postdoctoral Fellowship in Molecular Virology - The Scripps Research Institute Dr. Cao's research program centers on understanding how neuroinflammation contributes to neurodegenerative processes, with particular focus on Alzheimer's disease. His lab discovered that type I interferon, traditionally associated with antiviral responses, plays a pathogenic role in AD by promoting synapse elimination and impairing memory performance. Current investigations explore how genomic instability and transposable element dysregulation in aging contribute to neuroinflammation, and how peripheral immune responses and environmental factors influence brain pathology. Analysis of Dr. Cao's recent publications reveals a consistent research trajectory focused on the interface between immune responses and neurodegeneration. His work spans from fundamental molecular mechanisms of interferon signaling in microglia to translational studies examining therapeutic approaches for Alzheimer's disease. The publications demonstrate expertise in both neuroscience and immunology, with increasing emphasis on the role of aging-related genomic changes in neuroinflammatory processes. Dr. Cao leads the Cao Lab and is affiliated with several research centers including the Center for Perioperative Medicine, Consortium on Aging, and Neuroscience Research Center at UTHealth Houston. His research program appears to be well-funded through multiple NIH or similar grants, though specific funding sources aren't detailed in the provided text. The lab actively investigates the connections between peripheral immune responses, environmental factors, and brain pathology in neurodegenerative conditions. Dr. Cao's laboratory is part of the broader neuroscience research ecosystem at UTHealth Houston, collaborating with researchers across multiple disciplines to understand the complex interplay between immune responses and neurodegenerative processes. His work bridges basic science and potential clinical applications, particularly in developing interventions targeting neuroinflammatory pathways in Alzheimer's disease.