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Pabitra SahooView profile

Assistant Professor

• Molecular & Cellular Neuroscience
• Localized Protein Synthesis
• Stress Granules
• +8 more

Pabitra Sahoo is an Assistant Professor in the Department of Biological Sciences at Rutgers University, leading a research group focused on axonal mRNA dynamics and stress granule biology. His work bridges molecular neuroscience and regenerative medicine with direct implications for neural repair mechanisms. His educational background includes: B.S. from Utkal University, India (2005) M.S. from University of Hyderabad, India (2007) Ph.D. from National Centre for Cell Science, University of Pune (2013) Postdoctoral fellowship at Twiss Lab, University of South Carolina (2023) Dr. Sahoo's research centers on stress granules in axons and their dual role in physiological mRNA storage and pathological inhibition of nerve regeneration. His lab investigates how localized protein synthesis mechanisms govern neural repair, neurodevelopment, and neurodegenerative processes through cutting-edge approaches in spatial transcriptomics and axonal biology. Key discoveries include the identification of G3BP1 as a critical regulator of axonal mRNA translation and the demonstration that stress granules exist under normal physiological conditions in neurons. Analysis of his 2021-2025 publications reveals a dominant focus on stress granule disassembly mechanisms (particularly involving G3BP1), RNA-binding protein functions in axonal mRNA stability, and therapeutic targeting of these pathways for nerve regeneration. His work consistently connects fundamental molecular mechanisms to applications in spinal cord injury, peripheral nerve repair, and neurodegenerative conditions like ALS. The Sahoo Lab operates as a collaborative team of "curiosity driven, fun, and coffee loving scientists" investigating how mRNA storage granules respond to neuronal signals. Current projects specifically examine stress granule dynamics in neuronal development models and their dysfunction in neurodevelopmental disorders (e.g., Down syndrome) and neurodegenerative diseases, with therapeutic strategies emerging from multiple patent filings.

Sheng LiView profile

Associate Professor

• Cancer Epigenetics
• Aging
• Clonal Hematopoiesis
• +3 more

Sheng Li is an Associate Professor of Cancer Biology at the University of Southern California's Keck School of Medicine. She co-leads the Epigenetic Regulation in Cancer Program at the Norris Comprehensive Cancer Center. Her research integrates multi-omics and computational approaches to study epigenetic heterogeneity in blood cancers, aging, and clonal hematopoiesis. Her lab focuses on single-cell spatial multi-omics, 3D epigenomics, and long-read sequencing to map epigenetic drivers of leukemogenesis. Awards include the Leukemia & Lymphoma Society Scholar Award and AACR NextGen Star recognition. She mentors PhD students and postdocs, with her team publishing extensively in high-impact journals. Her publications demonstrate a strong emphasis on computational epigenetics, cancer systems biology, and geroscience. Recent work includes developing tools for spatial transcriptomics interpretation and modeling IDH-mutant AML gene networks.

• Immunology
• Cancer Therapy
• Oncology
• +3 more

Angelo Porciuncula is an Associate Research Scientist in the Department of Pathology at Yale School of Medicine, affiliated with the Schalper Lab. He holds a PhD from the University of Navarra. His research focuses on immunology, cancer therapy, and stem cell biology, with a particular emphasis on immune microenvironment modulation in oncology and translational drug development. Key projects include studying STING pathway activation via antibody-drug conjugates (e.g., TAK-500) targeting CCR2-expressing myeloid cells, as well as investigating immunotherapeutic biomarkers in lung cancer and glioblastoma. His work spans clinical-stage drug evaluation, tumor immunology, and epigenetic reprogramming of stem cells. Publications highlight contributions to understanding senescence mechanisms in cancer, pancreatic differentiation of iPSCs, and the role of OX40/OX40L pathways in tumor immunity. Porciuncula collaborates widely, including with Kurt Schalper and teams at Takeda Pharmaceuticals. His research bridges basic science and clinical applications, aiming to advance targeted therapies and regenerative medicine strategies.

Mansoureh EghbaliView profile

Professor

• Pulmonary Hypertension
• Myocardial Ischemia-Reperfusion Injury
• Sex Differences in Cardiovascular Disease
• +3 more

Mansoureh Eghbali, PhD, is a Professor in the Department of Anesthesiology at the David Geffen School of Medicine, University of California, Los Angeles. Her research program investigates molecular mechanisms of cardiovascular and pulmonary diseases with emphasis on sex-specific pathophysiology. She leads an active NIH-funded laboratory focused on pulmonary hypertension, myocardial ischemia-reperfusion injury, and the role of RNA-binding proteins in vascular remodeling. Her research integrates multiomics approaches to explore: Sex chromosome influences (Y-gene Uty) in pulmonary vascular protection MicroRNA regulation of cardiac fibrosis and calcification (e.g., miR-129-5p/Asporin axis) Gut-heart-lung interactions in diet-induced pulmonary hypertension Endothelial subpopulations (TM4SF1+) in disease progression Analysis of her recent publications reveals strong emphasis on: Integrative multiomics in vascular diseases Sex differences in drug responses Novel therapeutic targeting of RNA-binding proteins Cross-organ communication in cardiopulmonary pathologies She directs multiple NIH grants including: R01HL159865: Role of Chromosome Y gene, Uty (2021-2025) R01HL147586: Role of miR125 in pulmonary hypertension (2019-2023) R01HL129051: Role of miR193 in oxidized lipid-induced PH (2016-2021) R01HL131182: Epigenetic regulation by X chromosome (2016-2021)

• Cellular quiescence
• Metabolic regulation
• Cancer metabolism
• +4 more

Professor Hilary Coller holds joint appointments in Molecular, Cell and Developmental Biology and Biological Chemistry at UCLA. Her NIH-funded research explores cellular quiescence mechanisms, metabolic adaptations in dormant states, and stromal contributions to cancer progression. She currently serves as Editor-in-Chief of Physiological Genomics. Research domains: Metabolic regulation of quiescent stem cells Epigenetic control of cell cycle transitions MicroRNA networks in proliferation arrest Cancer-associated fibroblast biology Her laboratory developed novel biosensing technologies for in vivo metabolomics and contributed fundamental insights into mitochondrial regulation of cell cycle checkpoints. Educational leadership includes directing undergraduate genomics research programs.

• Non-coding RNA
• Gene Expression
• Developmental Biology
• +6 more

Matthew Ronshaugen is a Senior Lecturer in the Division of Developmental Biology & Medicine (L5) at the Faculty of Life Sciences, University of Manchester. He has held academic positions since 2007 as a Manchester Fellow, followed by Lecturer (2012-2017), and Senior Lecturer since 2017. 1991-1995: Bachelor of Arts in Philosophy and Linguistics, University of Nevada, Las Vegas 1995-1997: Master of Science in Systematics, University of Nevada, Las Vegas 1997-2002: Doctor of Philosophy in Cell and Molecular Biology, University of California, San Diego 2003-2007: Ruth L. Kirschstein NIH Postdoctoral Fellow at University of California, Berkeley His research focuses on non-coding RNAs (ncRNAs), particularly their roles in gene expression and developmental differentiation. His lab investigates how ncRNA evolution contributes to metazoan body plan diversification, centering on the Hox complex—a conserved genomic region rich in ncRNAs. He uses tiling microarrays and fluorescent in situ hybridization to analyze ncRNA dynamics in Drosophila, Tribolium, and Parhyale. Recent publications highlight his work on miRNA functions in embryonic development, aging-related changes in myeloid cells, and comparative transcriptomics across arthropods. His team employs genetics tools to dissect ncRNA roles in transcriptional regulation, epigenetic control, and silencing mechanisms. Scientific Awards: Ruth L. Kirschstein NIH Postdoctoral Fellow Manchester Fellow He supervises research on developmental transcriptomes and contributes to datasets on piRNA expression and Hox complex analysis. Collaborations span immunology, genomics, and evolutionary development, with outputs cited in fields like RNA interference, transgenics, and wound healing.

Jose M SilvaView profile

Professor

• Cancer Biology
• Cancer Genetics
• Tumorigenesis
• +5 more

Jose M Silva is a Professor in Pathology and Oncological Sciences at Columbia University Medical School. He holds adjunct faculty status and has prior roles including Assistant Professor at Columbia and postdoctoral training at Cold Spring Harbor Laboratory. His research focuses on cancer genomics, functional networks, and translating discoveries into clinical applications. He has pioneered integrative approaches combining genomics and systems biology to identify critical cancer cell regulators, leading to clinical trials. Education: BSc, Complutense University of Madrid PhD, Autonoma University of Madrid PostDoc & Senior Fellow, Cold Spring Harbor Laboratory Research Interests: His lab investigates breast cancer development and therapeutics, including molecular characterization of tumor networks, novel drug targets (e.g., RSF1, BIN3), and clinical translation of discoveries. Current efforts target triple-negative breast cancers and aging-cancer intersections. Grants & Trials: Initiated NCT02066532 clinical trial; ongoing work includes HDAC6/STAT3 inhibition studies and single-cell atlas projects.

Nancy PapalopuluView profile

Professor

• Developmental Neuroscience
• Cell State Transitions
• Gene Expression Dynamics
• +3 more

Nancy Papalopulu is Professor of Developmental Neuroscience in the Faculty of Life Sciences at the University of Manchester, where she leads research on cell state transitions and gene expression dynamics during development. Currently holding a Wellcome Trust Investigator Award (2022-2027), she has been a prominent figure in developmental neuroscience for over two decades, previously serving as a Wellcome Trust Senior Research Fellow from 2006-2022 and at the Wellcome Trust/Cancer Research UK Gurdon Institute in Cambridge from 2000-2006. Her research focuses on understanding how cells transition from progenitor states to differentiation with precise timing, or enter quiescence from which they may be reactivated. Using single cell quantitative approaches, live imaging, multiple experimental model systems (including Xenopus, zebrafish, and stem cell cultures), and mathematical modeling, her lab investigates the dynamics of gene expression that underlie cell fate decisions. A key contribution has been the hypothesis that the mutually antagonistic interaction between the neural progenitor transcription factor Hes1 and microRNA miR-9 generates pulsatile gene expression at the single cell level, which can transition to stable states in a time-controlled manner. Analysis of her recent publications reveals a strong focus on oscillatory gene expression patterns, neural development mechanisms, and the role of dynamics in cell fate determination. Her work spans developmental neuroscience, cancer biology (particularly glioblastoma), and pancreatic development, demonstrating the broad applicability of her research on gene expression dynamics. Scientific Awards and Recognition: Wellcome Trust Investigator Award (2022-2027) Wellcome Trust Senior Research Fellow (2006-2022) Wellcome Trust Senior Research Fellow (2000-2006) Wellcome Trust Career Development Fellow (1997-2000) Post-doctoral Fellow, Human Frontier Science Program Organization (1991-1996) Professor Papalopulu supervises multiple PhD students and postdoctoral researchers through various funding mechanisms including Wellcome Trust, MRC, and CRUK. Her current projects include 'A quantitative and dynamical approach to understanding cell state transitions' (2022-2027), 'Decoding Pulsing Proteins in the Pancreas' (2018-2022), and participation in the Centre for Biological Timing. Her laboratory team consists of postdocs, PhD students, and technicians working collaboratively on multiple aspects of developmental dynamics. The Papalopulu Lab maintains a strong presence in the field with 88 research outputs and active collaborations across multiple institutions. Her work contributes to UN Sustainable Development Goals related to good health and well-being through advancing fundamental understanding of developmental processes that underlie tissue formation, maintenance, and disease.

• Cell Adhesion
• Epithelial Cell Biology
• Desmosomes
• +7 more

Kathleen J. Green, PhD, is the Joseph L. Mayberry, Sr. Professor of Pathology and Toxicology and Professor of Dermatology at Northwestern University's Feinberg School of Medicine . She serves as Associate Director for Basic Sciences at the Robert H. Lurie Comprehensive Cancer Center and is affiliated with the Skin Biology and Diseases Resource-Based Center and Center for Genetic Medicine . Education: PhD in Cell and Developmental Biology (Washington University, 1982), Postdoctoral Training in Cell Biology (Northwestern, 1987) Green's research focuses on desmosomes —cell-cell adhesion structures—and their roles in epithelial tissue morphogenesis, cancer progression, and genetic skin diseases . Her work bridges basic science with translational applications , particularly for inflammatory skin diseases, melanoma, and heart disease . Recent publications highlight her lab's exploration of desmosome-mediated signaling pathways in skin stratification, melanoma growth, and inflammatory responses. Key themes include mechanotransduction, polarity regulation, and endosomal trafficking of adhesion proteins. Scientific Awards: Elected, German National Academy of Sciences (2016) Humboldt Research Award (2015) Tripartite Legacy Faculty Prize (2019) Feinberg Distinguished Woman in Medicine and Science (2011) Kligman Frost Leadership Award (2015) Green has mentored over 30 years, with former trainees now faculty at institutions like Emory, Yale, and Penn State. Her lab fosters collaborative, interdisciplinary research using human disease models, proteomics, and biophysical approaches to study epithelial mechanics.

C. Brooks MobleyView profile

Assistant Clinical Professor

• Skeletal Muscle Physiology
• Molecular Mechanisms of Exercise Training
• Sports Supplements
• +3 more

Dr. C. Brooks Mobley is an Assistant Clinical Professor at the School of Kinesiology, Auburn University. He directs the TigerFit Health & Fitness Laboratory and serves as Associate Director of the Nutrabolt Applied and Molecular Physiology Lab. With a Ph.D. in Kinesiology from Auburn University and postdoctoral training at the University of Kentucky, he specializes in skeletal muscle physiology and sports nutrition research. B.S. in Animal & Dairy Sciences (Auburn University) M.Ed. in Exercise Physiology (Auburn University) Ph.D. in Kinesiology (Auburn University) Postdoctoral Fellowship at University of Kentucky's College of Medicine His research explores molecular mechanisms of muscle plasticity, focusing on: Cellular adaptations to exercise training Ergogenic effects of sports supplements Muscle atrophy prevention strategies Mechanisms of skeletal muscle hypertrophy Angiogenesis in recovery scenarios Muscle-bone interaction dynamics Recent publications demonstrate expertise in: Mitochondrial adaptations to resistance training Epigenetic regulation of muscle growth Microbiome-exercise interactions Proteomic responses to disuse atrophy Firefighting occupational physiology Supplement efficacy studies Laboratory Leadership: TigerFit Health & Fitness Laboratory Nutrabolt Applied and Molecular Physiology Lab

Ayesha AliView profile

Professor

• Graphical Markov models
• Pollination networks
• Multivariate statistics
• +7 more

Ayesha Ali is a Professor of Statistics and Director of the Master of Data Science program at the University of Guelph. She holds a PhD in Statistics from the University of Washington (2002) and has expertise in statistical methods for complex high-dimensional systems, including ecological networks, causal inference, and bioinformatics. Her research integrates graphical Markov models, machine learning, and statistical computing to address challenges in plant-pollinator networks, livestock genetics, and disease risk modeling. Education: B.Sc. Honours in Statistics and Actuarial Science, University of Western Ontario (1996) M.Sc. in Statistics, University of Toronto (1998) Ph.D. in Statistics, University of Washington (2002) Research Interests: Graphical Markov models and ecological networks Causal inference and longitudinal data analysis Machine learning and high-dimensional predictive modeling Statistical methods for livestock genetics and animal health Computational statistics and bioinformatics Articles Trends: Her recent work spans interdisciplinary applications, including veterinary oncology biomarker discovery, remote sensing for agricultural suitability, and pipeline development for cross-species transcriptomics. She emphasizes graphical structure exploitation in regression and predictive modeling, with contributions to both theoretical and applied statistical methodologies. Awards: Canadian Journal of Statistics Award (2020) for groundbreaking work on doubly sparse regression NSERC Discovery Grant (2018) NSERC Collaborative Research and Development Grant (2015) Advising & Grants: She has supervised numerous graduate and undergraduate students on projects ranging from plant-pollinator network analysis to bioinformatics. Her grants include NSERC-funded research on milk fatty acid genetics and statistical methods for clustered data. Labs/Teams: Involved in the Bioinformatics program at the University of Guelph, contributing to interdisciplinary research collaborations in ecology and animal science.

• Pulmonary Fibrosis
• Lung Aging
• Single-Cell Profiling
• +3 more

Taylor Adams is a Researcher at the Yale School of Medicine's Internal Medicine Department, affiliated with the Kaminski Lab. Their work focuses on pulmonary fibrosis mechanisms, lung aging, and single-cell profiling, with a particular emphasis on epigenetic and immunological pathways. Adams collaborates closely with senior investigators like Naftali Kaminski, contributing to studies on fibrogenesis, drug development, and cellular dynamics in lung diseases. Research interests include understanding how epigenetic changes, microRNA regulation, and immune-cell interactions drive fibrotic processes. Recent work explores novel biomarkers for disease progression and non-invasive diagnostic methods. Adams' publications highlight advancements in spatial transcriptomics, somatic mutation analysis in aging lungs, and the role of GPR87 and CD103+ dendritic cells in fibrosis. Key contributions include identifying aberrant basaloid cells in IPF and developing computational tools like SDePER for deconvolving spatial transcriptomic data. Their lab's interdisciplinary approach integrates genomics, bioinformatics, and experimental models to translate findings into therapeutic strategies.

Syed HashshamView profile

Professor

• Environmental Biotechnology
• Microbial Ecology
• Bioremediation
• +4 more

Syed Hashsham is a Professor in the Department of Civil and Environmental Engineering at Michigan State University (MSU), with an adjunct appointment in the Center for Microbial Ecology and Plant, Soil, and Microbial Sciences. His research focuses on microbial community dynamics, field-deployable genetic testing tools, and environmental biotechnology processes. He leads the NIEHS Superfund Research Center’s Project 4 on dioxin remediation and has pioneered innovations like the Gene-Z handheld genetic analyzer and antimicrobial resistance gene screening chips. Education: Ph.D. in Environmental Engineering (University of Illinois, 1996), M.S. in Environmental Science (IIT Bombay, 1986), B.S. in Civil Engineering (Aligarh Muslim University, 1984). Research interests include microbial community stability, bioremediation of chlorinated solvents, and development of low-cost diagnostic tools. His work bridges environmental engineering and microbiology, with applications in water safety, soil remediation, and public health. Over 150 peer-reviewed publications and numerous grants from NIH, EPA, and other agencies highlight his impact. Notable awards include the MSU Distinguished Faculty Award (2011) and the Withrow Distinguished Scholar Award (2007). He teaches courses like Biological Processes in Environmental Engineering (ENE804) and advises on capstone projects. His lab has produced pioneering technologies for real-time microbial detection and environmental monitoring. Grants and collaborations span multi-million-dollar projects with the NIEHS, USDA, and U.S. Army. His team includes postdocs, PhD students, and visiting scholars working on topics like gut microbiome-host interactions and ARG dissemination via biofilms.

James R. GreenView profile

Professor

• Machine Learning
• Biomedical Informatics
• Computational Biology
• +9 more

James R. Green is a Professor in the Department of Systems and Computer Engineering at Carleton University , where he has been a faculty member since 2005. He holds a PhD from Queen's University and is a licensed Professional Engineer (P.Eng.) and Senior Member of IEEE. His work integrates machine learning, biomedical informatics, and high-performance computing. His educational background includes: B.A.Sc. in Systems Design Engineering, University of Waterloo (1998) M.Sc.(Eng.), Queen's University (2000) PhD, Queen's University (2005) Dr. Green's research focuses on machine learning challenges in biomedical informatics , particularly class imbalance and rare event prediction. Key areas include protein structure, function, and interaction prediction; microRNA detection in unique species; non-contact neonatal monitoring; and accelerating scientific computing via parallel architectures like the Cell BE processor. His lab has developed several widely used bioinformatics tools such as PIPE, ProtDCal, and PCI-SUMO. His recent publications reflect a strong trend in computational biology and machine learning , with applications in proteomics, genomics, and medical diagnostics. He has published over 100 peer-reviewed papers and secured funding from NSERC, CIHR, CFI, ORF, OCE, MITACS, and IBM. Scientific and teaching recognitions include: Three teaching awards NSERC Best Project Award (twice: 2006-2007 and 2007-2008) Multiple student projects resulting in conference papers (e.g., CMBEC) He has supervised numerous undergraduate capstone projects in areas such as assistive technologies, robotic systems, and bioinformatics. His teaching portfolio includes courses in Pattern Classification, Machine Learning, Computer Architecture, and Biomedical Engineering. He leads an active research group that bridges computer engineering and life sciences, fostering interdisciplinary collaboration. Lab and research team initiatives include: Development of open-access web servers for protein analysis Collaborations with biologists and clinicians Integration of hardware and software for medical applications

• Eukaryotic RNA processing
• Post-transcriptional gene regulation
• Spliceosome structure and mechanism
• +6 more

Melissa J. Moore, PhD, is Professor at the University of Massachusetts Chan Medical School, where she holds the Eleanor Eustis Farrington Chair of Cancer Research and serves in the RNA Therapeutics Institute. She also holds appointments in the T. H. Chan School of Medicine (Department of Chemical Biology) and the Morningside Graduate School of Biomedical Sciences (Departments of Biochemistry & Molecular Biotechnology, Interdisciplinary Graduate Program, and Translational Science). Additional affiliations include campus-wide programs in Bioinformatics & Integrative Biology and Chemical Biology. Education: BS in Chemistry/Biology, College of William and Mary PhD in Biological Chemistry, Massachusetts Institute of Technology Research Focus: Melissa Moore’s laboratory investigates post-transcriptional gene regulation in eukaryotes, with emphasis on three interconnected themes: (1) spliceosome structure and catalytic mechanism, (2) nuclear-to-cytoplasmic control of mRNA metabolism, and (3) quality control and clearance of defective ribosomal and messenger RNAs. The group combines biochemistry, single-molecule biophysics, RNA structural biology, and cell biology to dissect these processes at molecular and systems levels. Scientific Awards & Honors: Eleanor Eustis Farrington Chair of Cancer Research Funding & Collaborations: Work is supported by grants from the National Institutes of Health and involves ongoing collaborations with investigators at Brandeis University, MIT, University of Rochester, and other institutions. Rotation projects for graduate students are available in all active research areas. Laboratory & Team: The Moore laboratory is located in the RNA Therapeutics Institute at UMass Chan Medical School, 364 Plantation Street, Worcester, MA. The team employs state-of-the-art single-molecule imaging, mass spectrometry, and high-throughput sequencing to advance understanding of RNA biology and to translate insights into therapeutic RNA technologies.