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Rachel E. Klevit is a Professor of Biochemistry and holds the Edmond H. Fischer/Washington Research Foundation Endowed Chair at the University of Washington. She also serves as an Adjunct Professor in the Department of Chemistry within the College of Arts & Sciences. With a B.S. from Reed College and a Ph.D. from Oxford University, her research focuses on molecular recognition and protein-protein interactions critical to human disease. Her work combines structural, biochemical, and biophysical techniques, emphasizing NMR spectroscopy and mass spectrometry. Key research areas include BRCA1’s role in breast cancer, mechanisms of ubiquitination, small heat shock proteins (αB-crystallin, HSP27), and bacterial virulence factors like PhoQ. Her lab explores structural dynamics of proteins under stress and bacterial signaling pathways. Collaborations with microbiologists enhance understanding of pathogen-host interactions. Recent publications highlight advancements in kinetochore mechanics, heat shock protein activation, and automated HDX-MS analysis. Her endowed chair underscores recognition of her contributions to biochemical research. Ongoing projects aim to uncover substrate specificity of BRCA1/BARD1 and structural insights into bacterial sensor kinases. Laboratory activities are centered at the Health Sciences Building, with a focus on translational research bridging basic science and clinical applications. Her work integrates computational tools like HDXBoxeR for proteomic data analysis, reflecting a multidisciplinary approach to modern biochemical inquiry.

• Protein Biochemistry
• Structural Biology
• Cancer Research
• +3 more

Jun Xie is a Professor of Statistics and Graduate Chair in the Department of Statistics at Purdue University's College of Science. His research bridges causal machine learning, bioinformatics, and computational statistics with applications in genomics, proteomics, and precision medicine. Education: B.S. in Probability and Statistics, Peking University, 1994 M.S. in Probability and Statistics, Peking University, 1997 Ph.D. in Statistics, University of California, Los Angeles, 2000 Xie's research centers on causal machine learning and causal AI, specifically addressing causal inference from observational data when perfect interventions are absent. His group develops methods to integrate causal inference with machine learning for treatment effectiveness evaluation and precision medicine. He maintains significant contributions in bioinformatics, including Bayesian methods for genomics, proteomics, and statistical genetics, with applications in cotton fiber development and biomedical research. His recent publications (2022-2025) reveal a dominant focus on causal machine learning, featuring breakthroughs in causal representation learning and heterogeneous treatment effect estimation. Simultaneously, his bioinformatics work demonstrates strong continuity in multi-omics integration for plant science and biomedical applications, particularly in cotton development and vocal fold physiology. Scientific Awards: College of Science Outstanding Service Award, 2016 College of Science Team Award, 2014 Excellence in Research / Seed for Success, 2014 Excellence in Research / Seed for Success, 2012 College of Science Graduate Student Mentoring Award Xie has mentored 11 PhD graduates including Donglai Chen (2019) and Pengcheng Yang (2025), with 4 current PhD students. His NIH and NIFA-funded research supports work on causal inference methods and bioinformatics applications, particularly in agricultural and biomedical contexts. Xie leads an active research group focused on causal machine learning, developing methods for real-world data analysis where perfect interventions are absent. The group explores synergies between causal inference, machine learning, and AI, with recent emphasis on causal generative AI for precision medicine and treatment evaluation.

• Causal Machine Learning
• Causal AI
• Bayesian Statistics
• +7 more

Mark Woodin is a Senior Lecturer at Tufts University, holding primary appointment in the Department of Civil and Environmental Engineering at the School of Engineering. He also holds appointments in the School of Medicine (Public Health and Community Medicine) and the Friedman School of Nutrition Science and Policy. Since 1992, he has taught courses in epidemiology, biostatistics, and environmental health. He directs the Graduate Certificate Program in Epidemiology and leads the Epidemiology and Biostatistics track in the MPH Program. His research focuses on environmental epidemiology, exposure assessment, and public health disparities. Notable projects include studies on tungsten exposure and diabetes, ultrafine particle health impacts, and uranium contamination in Indigenous communities. Education: Sc.D. in Epidemiology from Harvard University (1998), M.S. from Tufts (1992), B.A. from UMass Amherst (1989). Professional activities include epidemiological consulting for St. John Parish, Louisiana, and membership in the American College of Epidemiology, Society for Epidemiologic Research, and International Society for Environmental Epidemiology. He teaches courses such as Principles of Epidemiology, Biostatistics, and Environmental Health Data Analysis across multiple Tufts campuses. His research spans environmental toxicology, cardiovascular health, and global health issues like cholera prevention through WASH interventions. He has collaborated on projects addressing occupational health disparities among low-wage immigrant workers and the 'healthy immigrant effect' in aging populations.

• Epidemiology
• Environmental Health
• Public Health
• +5 more

Mary B. Kennedy is the Allen and Lenabelle Davis Professor of Biology at the California Institute of Technology (Caltech). She holds a B.S. from St. Mary's College (1969) and a Ph.D. from Johns Hopkins University (1975). Her academic career at Caltech spans over four decades, progressing from Assistant Professor (1981–84) to Professor (1992–2002), and currently holds the Davis Professorship. Her research focuses on the molecular mechanisms underlying synaptic plasticity in the central nervous system, particularly the postsynaptic density (PSD) and its role in learning and memory. Dr. Kennedy's laboratory investigates how biochemical signaling networks in synapses regulate synaptic strength and connectivity. Key projects include studying the SynGAP protein's role in intellectual disability and autism, modeling calcium/calmodulin-dependent protein kinase II (CaMKII) dynamics using computational simulations, and exploring the structural organization of PSD proteins. Collaborations with computational biologists at the Salk Institute enhance her work on spatial models of synaptic signaling. Her research highlights the interplay between genetic mutations (e.g., synGAP haploinsufficiency) and synaptic dysfunction, linking molecular mechanisms to neurological disorders. Techniques employed include mass spectrometry, electrophysiology, mouse genetics, and advanced microscopy. Her contributions bridge biochemistry and neuroscience, emphasizing the importance of interdisciplinary approaches in understanding neural function.

• Neuroscience
• Molecular Biology
• Cellular and Developmental Biology
• +3 more

Dr. Jesse Rinehart is an Associate Professor in the Department of Cellular & Molecular Physiology at Yale School of Medicine, with a joint appointment in the Systems Biology Institute. His research focuses on decoding protein phosphorylation mechanisms using innovative phosphoproteomics and synthetic biology approaches. He developed a groundbreaking E. coli-based technology enabling site-specific phosphoserine incorporation into human proteins, advancing studies of phosphorylation networks. Education: PhD in Molecular Biophysics and Biochemistry, Yale University School of Medicine (2004) MS, Yale University (1999) BA, Kalamazoo College (1998) Research Interests: Dr. Rinehart’s work integrates systems biology with molecular physiology, emphasizing phosphorylation’s role in disease mechanisms such as cancer and hypertension. His lab explores how phosphorylation regulates ion transporters, signaling pathways, and metabolic processes. Recent breakthroughs include engineering genomically recoded organisms and identifying therapeutic targets for glioblastoma and kidney diseases. Key Contributions: Structural studies of sodium-chloride cotransporters and their inhibition by diuretics Development of phosphoserine resource tools for proteome-wide analysis Identification of PKM2’s role in gene regulation via G-quadruplex interactions Collaborations with neuro-oncology and diabetes research groups Labs & Teams: The Rinehart Lab at Yale West Campus employs interdisciplinary approaches, combining biochemistry, genetics, and computational modeling. Collaborations extend across departments including Biophysics, Pharmacology, and the Cancer Center.

• Protein Phosphorylation
• Phosphoproteomics
• Synthetic Biology
• +3 more

Ruixuan Gao is an Assistant Professor in the Department of Biological Sciences at the University of Illinois at Chicago (UIC). His research focuses on developing chemical and imaging tools to study molecular components and processes in biological systems. He specializes in expansion microscopy, light-sheet microscopy, and nanoscale imaging techniques to investigate nervous system structures, synaptic transmission, and pathological mechanisms in neurodegenerative diseases. Education: Postdoctoral Associate at MIT/HHMI Janelia Research Campus (2015-2020), Ph.D. from Harvard University (2015), B.S. from UC Berkeley (2009). Research interests include molecular assembly dynamics, synaptic ultrastructure, and Alzheimer’s disease pathology. His lab develops innovative methods like gel-assisted mass spectrometry imaging (GAMSI) and swellable hydrogels to map cellular components at unprecedented resolutions. Recent work bridges microscopy innovation with applications in neuroscience and cancer biology. Publications emphasize breakthroughs in nanoscale imaging, optogenetics, and molecular probe design. Collaborations with institutions like MIT, Harvard, and HHMI highlight interdisciplinary approaches to biomedical challenges.

• Molecular Biology
• Biological Imaging
• Expansion Microscopy
• +5 more

Yuko Tsutsui is a Research Scientist in the Department of Pharmacology at Yale School of Medicine. Her research focuses on structural biology, protein kinase signaling, and molecular mechanisms of enzyme inhibition. She employs advanced techniques like hydrogen-deuterium exchange mass spectrometry (HDX-MS) to study protein dynamics and conformational changes. Key areas of investigation include receptor tyrosine kinases, GPCR interactions, and drug resistance mechanisms in cancer-related kinases. Dr. Tsutsui has contributed to understanding EGFR mutations' inhibitor sensitivity and structural basis for ligand recognition in anaplastic lymphoma kinase. Her work spans from fundamental protein dynamics studies to translational insights into disease pathways. Research Highlights: Structural basis for dROS1-BOSS receptor interactions in developmental signaling Allostery mechanisms in BAK1 immune co-receptor activation Epigenetic regulation of E. coli lipopolysaccharide synthesis Structural insights into EGFR exon 19 mutation drug resistance Longstanding studies on serpin protein folding and stability Publications span structural biology, biochemistry, and molecular pharmacology, with contributions to Nature, Nature Communications, and PNAS. She collaborates with leading groups in pharmacology and structural biology at Yale and internationally.

• Structural Biology
• Protein Kinase Signaling
• Receptor Tyrosine Kinases
• +4 more

Yu Chen serves as a Postdoctoral Associate in the Department of Psychiatry at Yale School of Medicine. Their research focuses on integrating traditional herbal medicines with modern therapeutic strategies, particularly in oncology and infectious diseases. Key areas include developing novel antitumor agents like YIV-818-A, enhancing chemotherapy efficacy through PHY906 formulations, and investigating mechanisms of antibiotic synergy against MRSA biofilms. Research interests emphasize drug discovery from natural products, mechanism-based quality control (MBQC) of herbal preparations, and translational research in immune-oncology. Their work bridges traditional Chinese medicine (TCM) principles with contemporary pharmacological approaches, addressing challenges in antibiotic resistance, cancer treatment resistance, and inflammation-driven pathologies. Recent studies highlight advancements in combining YIV-906 with immunotherapy (e.g., anti-PD1), demonstrating enhanced tumor microenvironment modulation. Preclinical and clinical trials evaluate therapeutic synergies in rectal cancer and hepatocellular carcinoma. Publications span herbal pharmacology, drug delivery systems, and regulatory science frameworks for TCM standardization.

• Psychiatry
• Oncology
• Herbal Medicine
• +5 more

Paul Davies is a Research Professor in Neuroscience at the Tufts University School of Medicine. His research focuses on the physiology and pharmacology of Cys-loop ligand-gated ion channels (LGICs), particularly their roles in neuropsychiatric disorders like epilepsy, anxiety, and schizophrenia. He uses patch-clamp techniques to study ion channel function in LGICs. Davies holds a BSc and PhD from the University of Dundee. Research Interests: Ion channel pharmacology and physiology Mechanisms of GABAergic inhibition Neurosteroid actions on GABAA receptors Zinc-activated channel (ZAC) biology Neurodevelopmental disorders (e.g., Fragile X syndrome) Key Contributions: His work includes groundbreaking studies on KCC2 function in neural excitability, neuroactive steroids' therapeutic potential, and the discovery of ZAC antagonists. Recent articles (2021–2025) highlight advancements in understanding KCC2's role in neuron survival, ZAC variant effects, and novel treatments for seizure disorders. Grants & Funding: National Institutes of Health grants (2015–present) for research on neurosteroids, KCC2 mutations, and tonic inhibition deficits Industry partnerships, including Ovid Therapeutics collaborations Professional Activities: Davies serves on the IUPHAR NC nomenclature committee for ZAC channels and reviews for journals like Journal of Neuroscience and Neuropharmacology . He has presented at conferences such as Experimental Biology and the International Conference on Anesthesia.

• Neuroscience
• Pharmacology
• Ion Channel Physiology
• +4 more

Jeffrey Allen Borgia is an Associate Professor at Rush University Medical Center, holding joint appointments in the Department of Anatomy and Cell Biology and Department of Pathology . As Director of the Rush University Cancer Center Biorepository and Biomarker Development Core , he leads initiatives in translational research focused on novel diagnostic test development through multi-Omic profiling of patient specimens. Developing high-throughput biomarker discovery platforms using quantitative mass spectrometry and Luminex immunoassays Overseeing clinical trial specimen management and biorepository operations Specializing in lung cancer biomarkers and cancer cachexia mechanisms His research program integrates proteomics , glycomics , and circulating autoantibody profiling to improve early detection and treatment selection. Technology platforms include Agilent 6495 QQQ Mass Spectrometry, Luminex FlexMAP 3D, and laboratory automation systems. Active funding sources include grants from the National Cancer Institute , Brinson Foundation , Swim Across America , and industry collaborators like Serum Detect, Inc. and Tempus AI . His team includes post-doctoral fellows, clinical research coordinators, and laboratory staff working on patient-derived xenograft models and organoid cultures.

• Biomarker Development
• Cancer Pathophysiology
• Translational Medicine
• +3 more

Jessica Jackson is a Research Associate Professor in the Department of Chemistry at Colorado School of Mines. She holds a BS and PhD from Washington State University, with postdoctoral training at Colorado School of Mines and research experience at CEA (France). Her research focuses on radiochemistry, actinide separations, and f-element chemistry. Her work includes studying Pu-ligand complexes via mass spectrometry, developing extraction chromatography materials, and oxidizing americium using nano-sized bismuthate. She collaborates with institutions like CEA and the Flattop Critical Assembly. Her educational mission emphasizes training students in nuclear chemistry fundamentals and applications. Notable research areas include covalency in actinides, ligand degradation products, and separation techniques for nuclear fuel cycles. Her publications span solvent extraction, radiation chemistry, and thermodynamic analysis. She has advised under Dr. Jenifer Shafer and Laurence Berthon during her career. Labs/Teams: Active member of Mines' radiochemistry program, contributing to nuclear materials research and education initiatives.

• Radiochemistry
• Nuclear Chemistry
• Actinide Separations
• +3 more

Dr. Raj N. Singh is a Regents Professor and National Academy of Engineering (NAE) member at Oklahoma State University (OSU), leading the School of Materials Science and Engineering. He pioneered the melt infiltration (MI) process for ceramic matrix composites (CMCs), revolutionizing gas turbine engine components used by GE, Rolls-Royce, and NASA. His research focuses on advanced materials for energy storage, quantum systems, and biomedical applications. He holds over 28 patents and 350 publications, with honors including NAE membership, AAAS Fellowship, and NAI Fellow status. Education: Sc.D. in Ceramics (MIT), M.S. in Physical Metallurgy (University of Manitoba), B.S. in Metallurgical Engineering (IIT Kanpur). Research facilities include advanced characterization tools like microwave plasma systems and thermal analyzers. Advised numerous PhD/Master’s students, with notable graduates in CMCs and nanomaterials. Collaborations span industry (GE, AFRL) and academia. Key Awards: NAE Inductee (2024), Whitney Gallery of Technical Achievers (1990), Multiple Patent Medallions (GE-CR&D). Labs: Advanced Materials Characterization Center, dedicated MI-CMC R&D facilities. Grants: Supported by DOE, NSF, and industry partnerships. His work bridges materials innovation with industrial application, impacting aerospace, energy, and biomedical sectors.

• Nanostructured Materials
• Energy Storage Materials
• Biomaterials
• +5 more

Christian Schöneich is the Takeru Higuchi Distinguished Professor and Department Chair of Pharmaceutical Chemistry at the University of Kansas School of Pharmacy. He holds a Ph.D. in Chemistry from the Technical University of Berlin (1990) and a Diploma in Chemistry from the Free University of Berlin (1987). His research focuses on oxidative post-translational modifications of proteins in vivo and in pharmaceutical formulations, utilizing advanced proteomic and mass spectrometry techniques. Key areas include reactive oxygen species (ROS) mechanisms, protein oxidation in aging/disease, and stability of therapeutic proteins. He leads efforts to establish interdisciplinary proteomics infrastructure at KU and studies formulation stability of biologics like monoclonal antibodies and mRNA vaccines. Education: Ph.D. in Chemistry, Technical University of Berlin, 1990 Postdoctoral Fellowship, University of Kansas, 1991 Diploma in Chemistry, Free University Berlin, 1987 Research Interests: His work spans protein oxidation mechanisms, proteomic analysis of aging-related modifications, and stability challenges in pharmaceutical formulations. Specific projects include: Characterizing NO-induced protein modifications (e.g., S-glutathiolation of sarco/endoplasmic reticulum Ca-ATPase) Developing labeling chemistries for quantifying post-translational modifications Studying light-induced degradation of antibodies and cyclic peptides Optimizing mRNA vaccine storage stability and in-use conditions Publications: Recent work addresses mRNA vaccine stability, antibody-drug conjugate aggregation, and iron-catalyzed oxidation pathways. His 2023 review on mRNA formulation stability highlights storage challenges, while 2024 studies examine citrate buffer/Fe(III) mediated protein degradation. Grants & Collaborations: He collaborates on NIH-funded projects on protein oxidation in neurodegenerative diseases and leads initiatives to build proteomics infrastructure at KU. Research extends to industry partnerships optimizing biologic drug stability. Labs/Teams: His lab is part of the University of Kansas’s Proteomics Center, equipped with MALDI-TOF/TOF and ion trap mass spectrometers. Focus areas include analytical proteomics, drug formulation science, and oxidative stress biomarker discovery.

• Protein Stability
• Protein Oxidation
• Proteomics
• +5 more

Lev Gelb is an Associate Professor in the Department of Materials Science & Engineering at the University of Texas at Dallas (UTD), part of the Erik Jonsson School of Engineering and Computer Science. Previously, he held positions at Washington University in St. Louis and Florida State University. He earned a PhD in Theoretical Chemistry from Cambridge University (1995) and a BA in Chemistry from Columbia University (1992). His research focuses on computational materials science, including data analysis, machine learning, surface analysis methods, and energy storage systems. Key interests span free energy calculations, nanostructured materials, and high-performance computing. His work often involves molecular simulations of complex systems like colloidal gels, ionic liquids, and porous materials. Dr. Gelb has received awards such as the NSF CAREER Award and CISE Post-Doctoral Fellowship. His publications explore topics like aerogel modeling, TOF-SIMS data analysis, and phase equilibria in confined geometries. He is affiliated with professional organizations such as AIChE and ACS. While currently not accepting undergraduate students, his research encompasses collaborations in computational mechanics, materials characterization, and interdisciplinary projects at the intersection of chemistry and engineering.

• Data analysis
• Machine learning
• Surface analysis methods
• +5 more

Tania Gendron, Ph.D., is an Associate Professor of Neuroscience at Mayo Clinic in Jacksonville, Florida, where she leads the Translational Neurobiology of ALS and FTD Laboratory. She holds an administrative appointment as Associate Consultant II-Research in the Department of Neuroscience and is actively engaged in cutting-edge research on neurodegenerative disorders. Education: Ph.D. in Cellular and Molecular Medicine, University of Ottawa B.S. in Biochemistry, University of Ottawa Dr. Gendron's research focuses on the molecular underpinnings of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), particularly those linked to the C9orf72 gene mutation. Her laboratory investigates the role of protein aggregates such as TDP-43 and tau, and pioneered the discovery of dipeptide repeat (DPR) proteins as a key pathological feature. A major thrust of her work is biomarker discovery, with significant contributions in establishing poly(GP) DPR proteins and neurofilament light as promising biomarkers for diagnosis, prognosis, and therapeutic monitoring in ALS, FTD, and related disorders. Analysis of her recent publications reveals a consistent focus on neurodegenerative disease mechanisms, with a strong emphasis on C9orf72 pathology, TDP-43 dysfunction, DPR protein toxicity, and the development and validation of fluid-based biomarkers. Her work spans basic molecular mechanisms to translational applications, often utilizing patient-derived tissues and preclinical models. Scientific Awards and Grants: National Institute of Neurological Disorders and Stroke (NINDS) grant as Principal Investigator (PI) for 'c9RAN proteins as a biomarker for C9ORF72-associated ALS and FTD' NINDS grant as PI for 'Core C' project NINDS grant as Co-PI for 'Frontotemporal dementia and related disorders: transcriptomic profiling, biomarker discovery, and mechanistic insight' NINDS grant as Co-PI for 'Pathobiology of Neurodegeneration in C9ORF72 repeat expansion' NINDS grant as Co-PI for 'Poly(ADP-ribose) promotes the condensation and toxicity of C9orf72 arginine-rich dipeptide repeat proteins' Dr. Gendron has secured significant grant funding, indicating national recognition of her research. She actively collaborates with prominent researchers at Mayo Clinic, including Dr. Leonard Petrucelli and Dr. Mariet van Blitterswijk. Her laboratory is a key component of the Neuroscience Research, Discovery, and Translation Labs at Mayo Clinic, contributing to the institution's mission of advancing patient care through innovative research. She has published over 130 peer-reviewed articles and her work has been supported by multiple NIH grants, reflecting a sustained and impactful research program.

• Neurodegenerative Diseases
• Amyotrophic Lateral Sclerosis (ALS)
• Frontotemporal Dementia (FTD)
• +7 more