About
Dr. Jesse Rinehart is an Associate Professor in the Department of Cellular & Molecular Physiology at Yale School of Medicine, with a joint appointment in the Systems Biology Institute. His research focuses on decoding protein phosphorylation mechanisms using innovative phosphoproteomics and synthetic biology approaches. He developed a groundbreaking E. coli-based technology enabling site-specific phosphoserine incorporation into human proteins, advancing studies of phosphorylation networks.
Education:
- PhD in Molecular Biophysics and Biochemistry, Yale University School of Medicine (2004)
- MS, Yale University (1999)
- BA, Kalamazoo College (1998)
Research Interests: Dr. Rinehart’s work integrates systems biology with molecular physiology, emphasizing phosphorylation’s role in disease mechanisms such as cancer and hypertension. His lab explores how phosphorylation regulates ion transporters, signaling pathways, and metabolic processes. Recent breakthroughs include engineering genomically recoded organisms and identifying therapeutic targets for glioblastoma and kidney diseases.
Key Contributions:
- Structural studies of sodium-chloride cotransporters and their inhibition by diuretics
- Development of phosphoserine resource tools for proteome-wide analysis
- Identification of PKM2’s role in gene regulation via G-quadruplex interactions
- Collaborations with neuro-oncology and diabetes research groups
Labs & Teams: The Rinehart Lab at Yale West Campus employs interdisciplinary approaches, combining biochemistry, genetics, and computational modeling. Collaborations extend across departments including Biophysics, Pharmacology, and the Cancer Center.
