Zheng Ruan

Zheng Ruan serves as an Assistant Professor in the Department of Biochemistry & Molecular Biology at Thomas Jefferson University's College of Life Sciences, conducting research at the intersection of structural biology and membrane protein function.

His expertise centers on Structural Biology and Biochemistry, with specialized focus on Cryo-EM techniques to investigate membrane proteins and receptors. Key research areas include the proton-activated chloride channel (PAC) and TRPM channels, examining molecular mechanisms of pH sensing, desensitization, and ligand interactions like PIP2 modulation. His work bridges structural insights with physiological channel behavior.

Recent publications demonstrate consistent focus on ion channel structural mechanisms, particularly TRPM5 activation/inhibition and PAC channel regulation. These studies employ high-resolution structural approaches to reveal conformational changes underlying channel function, with implications for therapeutic targeting of membrane protein disorders.

Dr. Ruan maintains an active research laboratory as indicated by his dedicated laboratory website, where his team investigates the structural basis of ion channel physiology using advanced biophysical methodologies.