Lysosomal function Professors and Supervisors | ApplySharif

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Daping FanView profile

Professor

University of South CarolinaUnited States

Dr. Daping Fan is a Professor in the Department of Cell Biology and Anatomy at the University of South Carolina School of Medicine Columbia. His research focuses on macrophage biology in atherosclerosis and cancer, exploring mechanisms of inflammation and tumor progression. He holds a B.S. and M.D. from Nanjing University School of Medicine and a Ph.D. in Biochemistry & Molecular Biology from Southern Illinois University. Education: 1992 B.S. in Medicine, Nanjing University School of Medicine 1994 M.D. in Clinical Medicine, Nanjing University School of Medicine 2004 Ph.D. in Biochemistry & Molecular Biology, Southern Illinois University Research Focus: Macrophage-driven inflammation in atherosclerosis and tumor microenvironment dynamics, with emphasis on therapeutic strategies targeting cholesterol homeostasis and immune regulation. Key Projects: Investigates roles of miRNAs (e.g., miR-155, miR-34a), TFEB signaling, and natural compounds like emodin in modulating macrophage function. Explores gut microbiota's impact on cancer cachexia and inflammatory bowel disease.

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Aleister SaundersView profile

Professor

Drexel UniversityUnited States

Aleister Saunders, PhD, is a Professor in the Department of Biology at Drexel University and serves as Executive Vice Provost for Research & Innovation. He leads Drexel's research strategy, securing R1 classification (2018–2022), and oversees major initiatives like the Advanced Functional Fabrics of America (AFFA) collaboration with MIT. His research focuses on Alzheimer’s disease pathogenesis, exploring genes and pathways involved in disease progression. He has pioneered invertebrate models (e.g., Drosophila) to study Alzheimer’s mechanisms and has contributed to drug discovery efforts targeting APP metabolism. Saunders’ lab integrates biochemistry, genetics, and molecular biology to identify novel therapeutic strategies. Education: BS in Biochemistry, Pennsylvania State University PhD in Biochemistry, University of North Carolina Postdoctoral Fellowships at Harvard Medical School Research Interests: Saunders’ work centers on Alzheimer’s disease, with a focus on APP processing, protein quality control, and drug-like compound discovery. His lab investigates amyloid-β’s role in disrupting cellular signaling (e.g., Sonic hedgehog pathways) and employs Drosophila models to study synaptic and behavioral deficits. Awards & Impact: Saunders has advanced Drexel’s innovation ranking and led partnerships with organizations like Spark Therapeutics for gene therapy facilities. His research is funded by NIH, NSF, and foundations such as the Cure Alzheimer’s Foundation. Grants & Leadership: Directed the RNAi Resource Center at Drexel Member of NIH study sections Board member of the University City Science Center Labs & Facilities: Saunders oversees Drexel’s Center for Functional Fabrics and the PA Fabric Discovery Center, advancing textile-based biomedical innovations. His lab is located in PISB 401 C2.

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Ka Ho LeungView profile

Academic

Clarkson UniversityUnited States

Ka Ho Leung is a Research Assistant Professor in the Department of Chemistry & Biochemistry at Clarkson University, affiliated with the Coulter School of Engineering & Applied Sciences. He holds a B.S. (2011) and Ph.D. (2015) in Chemistry from Hong Kong Baptist University, followed by postdoctoral research at the University of Chicago under Prof. Yamuna Krishnan. His research focuses on developing nanosensors for quantitative imaging of cellular organelles and understanding cell physiology, supported by grants from the National Institute of General Medical Sciences. Notable achievements include the 2022 Maximizing Investigators' Research Award. Education: B.S. Chemistry, Hong Kong Baptist University (2011) Ph.D. Chemistry, Hong Kong Baptist University (2015) Postdoctoral Scholar, University of Chicago (2015–2021) Research interests integrate Nanotechnology, Chemical Biology, and Bioanalytical Chemistry to design nanodevices for in vivo organelle imaging and functional analysis. Key projects include DNA nanomachines for lysosome characterization and pH-correctable calcium sensors. His group actively recruits undergraduates interested in Chemical Biology, Fluorescence Imaging, and Cell Culture. Publications span high-impact journals like Nature Nanotechnology and Nature Methods , emphasizing interdisciplinary approaches to cellular imaging and molecular diagnostics. The lab’s work has been highlighted in Phys.org and Nature Reviews Materials . Grants: National Institute of General Medical Sciences funding supports ongoing research. The Leung Research Group collaborates across disciplines to advance therapeutic applications of nanotechnology and cellular diagnostics.

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Ashutosh TiwariView profile

Professor

Michigan Technological UniversityUnited States

Ashutosh Tiwari is a Professor of Chemistry at Michigan Technological University and Faculty Fellow for Research Integrity. His research program investigates protein misfolding and aggregation mechanisms in neurodegenerative disorders. The Tiwari laboratory employs biochemical, biophysical, and cell biology approaches to characterize protein instability in conditions including ALS, Alzheimer's, and Parkinson's diseases. Research goals focus on connecting in vitro protein aggregation phenomena with cellular toxicity mechanisms in neurodegenerative contexts. Recent publications develop novel fluorescent probes for cellular imaging applications and examine molecular mechanisms of amyloid formation. Instrumentation includes vibrational spectroscopy, mass spectrometry, and advanced microscopy techniques to characterize protein structures and interactions.

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Ranjit PatiView profile

Professor

Michigan Technological UniversityUnited States

Ranjit Pati is a Professor and Graduate Director in the Department of Physics at Michigan Technological University. He holds a PhD in Theoretical Condensed Matter Physics from the University at Albany, SUNY. His research focuses on addressing fundamental challenges in nanoscience, particularly electron transfer processes in nanoscale junctions using quantum many-body theory. Dr. Pati's work explores quantum materials including molecular junctions, carbon nanotubes, nanowires, and graphene nanoflakes. His research investigates how electron behavior can be controlled in these materials for electronics applications. He maintains active collaborations with institutions like the University of Iowa and Yale University. He leads significant projects including NSF-funded research on 'Designing Molecular Spin Switch' (2012-2014) and 'Theory of mono-molecular field effect organic transistors' (2007-2013). His computational facilities include a Beowulf Linux Cluster for Gaussian and VASP simulations. Scientific Recognition: Recipient of NSF Career Award (2007-2013) Principal Investigator on multiple NSF grants including current NSF-BSF collaboration (2023-2026) Featured in Michigan Tech News and international science media for quantum computing research Dr. Pati advises numerous graduate and undergraduate students in nanoscale physics research. His outreach includes educational programs like 'Mission Elektron' to inspire future engineers.

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Nicole TemplemanView profile

Assistant Professor

University of VictoriaCanada

Nicole Templeman is Assistant Professor and Canada Research Chair in Cell Biology at University of Victoria. Her research investigates mechanisms of reproductive aging using C. elegans and mouse models, focusing on nutrient-sensing pathways and oocyte quality maintenance. Research Program: Nutrient-signaling regulation of reproductive aging Insulin pathway modulation of oocyte quality Evolutionarily conserved mechanisms of fertility preservation Laboratory Team: 3 PhD candidates and MSc students Multiple undergraduate researchers Honors & Funding: Canada Research Chair (Tier 2) in Cell Biology Michael Smith Health Research BC Scholar Jarislowsky Fellowship-Banting Discovery Award

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Sreeparna BanerjeeView profile

Professor

Middle East Technical UniversityTurkey

Summary Prof. Sreeparna Banerjee is a Professor in the Department of Biological Sciences at Middle East Technical University (METU), Ankara, Turkey. Her research focuses on colorectal cancer metabolism, particularly the metabolic pathways deregulated in cancer cells, including lipid and carbohydrate metabolism, and their role in inflammatory pathways. Her laboratory investigates how targeting these pathways can enhance chemotherapy sensitivity and identify novel drug targets. Education Ph.D. in Food Science, University of Leeds (2002) M.Sc. in Food Science, University of Leeds (1998) B.Sc. in Physiology, University of Calcutta (1997) Research Highlights Her work emphasizes metabolic plasticity in cancer cells under nutrient deprivation, lysosomal dynamics, and epithelial-mesenchymal transition (EMT). Recent studies include glutamine withdrawal effects on lipid metabolism in metastatic CRC, lysosomal alkalinization mechanisms, and drug delivery systems using polymer-based microparticles. Her lab employs innovative models like the chorioallantoic membrane assay for studying autophagy and metastasis. Publications & Collaborations Over 100 peer-reviewed publications, including high-impact journals such as Cell Proliferation , Scientific Reports , and Cellular Oncology . Collaborations span biomaterials science, nanotechnology, and systems biology. Recent work includes cross-disciplinary projects on phase-separated cellular condensates and targeted drug delivery systems. Professional Activities Thesis advisor to 40+ students. Active in METU's research community, with a strong focus on training early-career researchers in cancer metabolism and translational oncology.

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Christopher L BrettView profile

Professor

Concordia UniversityCanada

Dr. Christopher L Brett is a Professor of Biology at Concordia University, serving as Co-Director of the Centre for Microscopy and holding the Concordia University Research Chair in Applied Cell Science. He holds a PhD from Johns Hopkins University and a Postdoctoral Fellowship from the University of Washington. His research focuses on fundamental lysosome biology, aging mechanisms, and engineered extracellular vesicles for therapeutic applications. Key areas include lysosomal transporter degradation pathways, membrane fusion dynamics, and organelle trafficking under stress conditions. Recent publications highlight his work on sphingolipid regulation of vacuole fusion, stress-induced membrane fission mechanisms, and novel cell-free assays for studying multivesicular body-lysosome interactions. His work bridges molecular mechanisms with translational applications in drug delivery and disease modeling. Awards are listed in his profile, though specific honors are not detailed. His lab (Brett Lab) explores lysosomal biology and vesicle engineering, with research outputs emphasizing organelle membrane dynamics and cellular stress responses. Collaborative grants and interdisciplinary work are central to his academic contributions.

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Ralf ZwackaView profile

Senior Lecturer

University of EssexUnited Kingdom

Dr. Ralf Zwacka is a Senior Lecturer at the University of Essex , School of Life Sciences, with a focus on cancer biology and stem cell research. His career spans multiple institutions, including the University of Galway, University of Ulm, and University of Edinburgh. Education: BSc Biochemistry (University of Manchester), PhD (Open University and Forschungszentrum Karlsruhe), MBA Dr. Zwacka's research centers on mesenchymal stem cells (MSCs) as gene delivery vehicles, apoptosis pathways in cancer, and redox-regulated mechanisms in tumor progression. He investigates how MSCs influence tumor metastasis and how epigenetic regulation (e.g., miRNAs) affects cancer cell death. His publications highlight trends in TRAIL-based therapies , MSC engineering , and apoptosis modulation in pancreatic, prostate, and colorectal cancers. Recent work explores SARS-CoV-2 entry inhibition via antiandrogens like enzalutamide. Grants and Funding: Current projects include Next-Generation Liquid Biopsies for pancreatic and colorectal cancer diagnostics (Pancreatic Cancer UK, Bowel Cancer UK), and a COVID-19 Therapeutics Development grant from the University of Essex. Teaching Responsibilities: Courses in Stem Cell Biology , Molecular Basis of Cancer , and Advanced Research Skills . He supervises PhD and MSc students, including Aleyna Gouney , Serap Gokcen Dogan , and Tianyuan Chu .

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Carole LINSTERView profile

Associate Professor

University of LuxembourgLuxembourg

Carole LINSTER is an Associate Professor in Biochemistry at the University of Luxembourg's Luxembourg Centre for Systems Biomedicine (LCSB), leading the Enzymology & Metabolism group. Her research focuses on understanding metabolic pathways, metabolite repair mechanisms, and their roles in neurodegenerative and metabolic disorders. She investigates how cellular metabolism interacts with disease progression, particularly in mitochondrial dysfunction and neurodevelopmental syndromes. Key research areas include: - Metabolite damage and repair pathways - Enzymatic mechanisms in metabolic disorders - Systems biomedicine approaches to disease biomarkers - Neurological and metabolic perturbations in genetic disorders Her recent work highlights breakthroughs like CLYBL's role in vitamin B12 homeostasis, ketogenic diet effects on colorectal cancer via microbiome interactions, and NAXD deficiency's neurodegenerative consequences. She employs advanced metabolomics, yeast models, and clinical studies to bridge basic science and translational medicine. Publications span topics from mitochondrial disease biomarkers to drug repurposing for epilepsy. Her lab integrates systems biology and biochemical approaches to uncover novel therapeutic targets, emphasizing metabolite-driven mechanisms in health and disease.

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Liqing HeView profile

Assistant Professor

University of LouisvilleUnited States

Liqing He is an Assistant Professor at the University of Louisville, specializing in molecular systems biology with a focus on metabolomics and epitranscriptomics. His research integrates bioanalytical chemistry and bioinformatics to address biomedical challenges, particularly in alcohol-associated liver disease, environmental toxicology, and cancer metabolism. Education: Ph.D. in Biomedical Engineering (Xi’an Jiao-tong University, 2016), M.S. in Zoology (Shaanxi Normal University, 2006), and B.S. in Biology Education (Shaanxi Normal University, 2003). Research Interests: Dr. He develops advanced chromatography-mass spectrometry platforms for analyzing nucleosides, bile acids, and metabolites. His work includes epitranscriptomic analysis of modified oligonucleotides and metabolomic studies on disease mechanisms. Key projects involve alcohol-induced liver pathology, probiotic interventions, and cancer metabolic pathways. Publications: Over 30 peer-reviewed articles, including high-impact studies in Cancers , Hepatology , and IScience , focusing on biomarker discovery, metabolic profiling, and therapeutic strategies. Grants & Collaborations: Active in interdisciplinary projects combining experimental and computational approaches. His lab explores multi-omics approaches to understand disease mechanisms and develop preventive/therapeutic tools. Labs/Teams: Leads research in bioanalytical methods and metabolomics, collaborating with groups in biomedical engineering, oncology, and environmental health.

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Kirill KiselyovView profile

Associate Professor

University of PittsburghUnited States

Kirill Kiselyov is an Associate Professor in the Department of Biological Sciences at the University of Pittsburgh’s Kenneth P. Dietrich School of Arts and Sciences. His research focuses on ion channel function, lysosomal biology, and cellular degradation pathways, with particular emphasis on lysosomal storage diseases and their implications in cancer and neurodegenerative disorders. He leads a lab investigating how cells monitor and respond to disruptions in the endocytic pathway, leveraging genetic and pharmacological approaches to identify therapeutic targets. Key research themes include the role of TRPML1 channels in lysosomal calcium signaling, autophagy-lysosomal dysfunction in disease, and the interplay between lysosomal and mitochondrial systems in cancer progression. His lab employs diverse models, including human cancer cells, Drosophila, and mouse models, to study these mechanisms. Kiselyov’s work bridges basic cellular biology with translational research, aiming to develop novel treatments for conditions like mucolipidosis IV and head and neck cancers. His articles highlight advancements in understanding lysosomal-exocytosis regulation, PRMT inhibitor applications in cancer therapy, and the pathophysiology of genetic disorders linked to ion channel dysfunction. Collaborative efforts include studies on drug sensitivity modulation and biomarkers for cellular stress responses. Kiselyov actively engages in education through innovative pedagogical approaches, such as peer-reviewed presentation exchanges in undergraduate classrooms.

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Andreas JennyView profile

Professor

Albert Einstein College of MedicineUnited States

Andreas Jenny is a Professor at the Albert Einstein College of Medicine, holding joint appointments in the Departments of Developmental & Molecular Biology, Genetics, and Medicine. His research focuses on autophagy pathways, lysosomal function, and developmental processes in Drosophila. Key areas include endosomal microautophagy (eMI), lysosomal acidification mechanisms, and Rho Kinase's role in spermatogenesis. He pioneered a Drosophila genetic model for studying eMI and discovered Lamp1's role in lipid transport and lysosomal pH regulation. His work links basic science to neurodegenerative diseases like Parkinson's and male infertility. Education details are not explicitly stated in the text, but his academic contributions span over two decades. Research highlights include collaborations with the Cuervo lab and development of imaging tools like the SParQ plugin for vesicle quantification. He has published extensively in Autophagy , Development , and PNAS , with over 30 primary articles and reviews since 2014. His lab investigates the intersection of metabolism, organelle dynamics, and genetic signaling in health and disease. Key Projects: Genetic screens for eMI regulators Lamp1's role in sterol/diacylglycerol metabolism Rho Kinase/Combover in sperm individualization Awards: None explicitly listed in text Grant and advisory activities are not detailed here, but his work has been supported by collaborations with institutions like the Undiagnosed Diseases Network and NIH-funded projects. He leads a multidisciplinary team integrating genetics, cell biology, and computational tools to address fundamental biological questions with clinical relevance.

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Robert H. SingerView profile

Professor

Albert Einstein College of MedicineUnited States

Robert H. Singer is a Professor and Co-Chair of Anatomy & Structural Biology, Professor of Cell Biology and Neuroscience at Albert Einstein College of Medicine. He holds the Harold and Muriel Block Chair in Anatomy & Structural Biology and co-directs the Gruss Lipper Biophotonics Center and the Integrated Imaging Program. His research focuses on RNA dynamics, including single-molecule imaging of mRNA from transcription to degradation, and developing advanced microscopy techniques. He leads a lab renowned for innovations in fluorescent RNA labeling and real-time tracking of mRNA trafficking in living cells. Research Interests: Dr. Singer’s work centers on understanding RNA expression, localization, and translational regulation. His lab pioneered methods to visualize RNA in living cells using fluorescent probes and super-resolution microscopy, enabling the study of mRNA behavior in neurons, fibroblasts, and yeast. Key topics include RNA localization mechanisms, stress granule formation, and the impact of mRNA dynamics on health and disease. Patents: He has authored numerous patents, including technologies for RNA visualization (e.g., US Patent #6,586,240), multi-fluor FISH assays, and in-situ hybridization methods. These innovations underpin his lab’s contributions to biotechnology and diagnostics. Lab & Collaborations: The Singer Lab collaborates widely, advancing tools for studying HIV latency, coronavirus replication, and RNA-protein interactions. His team includes over 50 current and former trainees, reflecting a commitment to mentoring the next generation of scientists. Publications: Recent work spans topics like mRNA stability in yeast, intercellular RNA transfer, and imaging techniques for neurodegenerative diseases. Over 200+ publications highlight his lab’s interdisciplinary impact in cell biology, neuroscience, and biophysics.

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Emma WatsonView profile

Assistant Professor

University of Massachusetts Chan Medical SchoolUnited States

Dr. Emma Watson is an Assistant Professor in the Department of Systems Biology at UMass Chan Medical School, leading a research group focused on cancer chromosome genetics and tumor genome evolution. Her work utilizes forward- and reverse-genetic technologies to model tumor-like genomes and investigate chromosomal abnormalities in breast, renal, and pancreatic cancers. She earned her B.S. in Biophysics from UConn and Ph.D. in Biomedical Sciences from UMass Chan, followed by a Damon Runyon Postdoctoral Fellowship at Harvard Medical School. Her research explores how cancer chromosomal abnormalities drive pro-growth phenotypes during tumor evolution. Key interests include dissecting tissue-specific tumor aneuploidy patterns, rare cancer fusion oncogene networks, and therapeutic targeting of chromosomal aberrations. The Watson Lab employs high-throughput genetic screens, comparative genomics, and phenotypic profiling to uncover vulnerabilities in cancer genomes. Publications demonstrate strong trends in cancer systems-genomics, spanning mechanistic studies of metabolic dependencies, chromosomal evolution screens, and CRISPR-based therapeutic strategies. Awards include the 2024 Young Investigator Award from Breast Cancer Alliance. Dr. Watson advises PhD candidates and research associates investigating targeted therapies and fusion oncogene pathogenesis. The lab maintains active collaborations on metabolic perturbation studies and rare cancer networks. Facilities include advanced genomic tools and imaging resources, with projects extending to neurodegenerative disease models where chromosomal instability intersects with metabolic pathways.

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