Bassel SawayaView profile
Professor
Bassel Sawaya, PhD, MS is a Professor at the Lewis Katz School of Medicine , Temple University , with affiliations to the Fels Cancer Institute for Personalized Medicine , Center for Substance Abuse Research , and Neural Sciences department. His research focuses on understanding the molecular mechanisms of HIV-1 associated neurocognitive disorders (HAND) in the HAART era. Research interests include: Neurotoxic effects of HIV-1 proteins (Tat, Vpr, gp120) MicroRNA regulation in neurodegeneration Metabolic reprogramming in viral pathogenesis Blood-brain barrier dysfunction Neuronal injury mechanisms Recent publications highlight: 2025 study on CK1δ-SNAPIN-lysosomal dysfunction in HAND 2023 discoveries on gp120-calcineurin pathway interactions 2022 work on metabolic shifts in neuroAIDS and SARS-CoV-2 2019-2013 investigations into Tat/Vpr neurotoxicity His lab employs molecular, virological, and cellular approaches to dissect HIV-1 pathogenesis. Current work explores therapeutic targets for HAND through microRNA and metabolic pathway modulation.









