Megan McCleanView profile
Associate Professor
Megan McClean is an Associate Professor in the Department of Biomedical Engineering at the University of Wisconsin–Madison, College of Engineering. Her research integrates bioengineering, microfluidics, and optogenetics to study microbial signal processing, with a focus on model and pathogenic yeasts. Research Interests: Systems Biology: Investigating how cells process complex stimuli through dynamic signaling networks. Synthetic Biology: Designing and building biological systems for controlled experimentation. Cellular Engineering: Developing tools to manipulate and monitor cellular behavior. Signal Processing: Understanding how biological inputs are transduced and interpreted at the cellular level. Her recent publications highlight a strong emphasis on high-throughput optogenetic platforms like Lustro, automation in biological experiments, and quantitative analysis of yeast signaling and gene regulation. The work spans synthetic biology, systems biology, and bioengineering, with increasing integration of microfluidics and real-time cellular monitoring. Scientific Awards: National Science Foundation CAREER Award (2021) WARF Innovation Award Finalist (2020) Cellular and Molecular Bioengineering Young Innovator Award (2019) Maximizing Investigators’ Research Award (2018) Frontier Innovator, Wellcome Trust (2015) Kavli Fellow, US National Academy of Sciences (2015) Burroughs Wellcome Fund Career Award at the Scientific Interface (2013) Lewis-Sigler Fellowship, Princeton University (2009) Lucent GRPW Graduate Fellowship (2003) Peirce Fellowship, Harvard SEAS (2003) Member, Phi Beta Kappa (2003) UC Berkeley Alumni Scholars Leadership Scholarship (2000) Member, Phi Theta Kappa (1996) Advising & Grants: She advises graduate students through BME 890 (Pre-dissertation Research) and BME 990 (Research and Thesis), indicating active mentorship. Her research is supported by major grants including the NSF CAREER Award and the NIH Maximizing Investigators’ Research Award, reflecting sustained funding and recognition. Labs & Teams: The McClean research group develops and applies advanced bioengineering tools such as microfluidic devices and optogenetic platforms to study cellular decision-making in yeast. The team emphasizes high-throughput, automated experimentation, as demonstrated by the Lustro system.








