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Thomas CokelaerView profile

Researcher

• Bioinformatics
• Data Analysis
• Machine Learning
• +12 more

Thomas Cokelaer is a researcher at the Institut Pasteur, affiliated with the Bioinformatics and Biostatistics HUB and based at the Platform Biomics. Since October 2018, he has led the SALSA (dry-lab) group, focusing on bioinformatics software development and data analysis. His interdisciplinary background spans astronomy, plant modeling, systems biology, and drug discovery. Institution: Institut Pasteur Unit: Bioinformatics and Biostatistics HUB Platform: Platform Biomics Group: SALSA (dry-lab group) leader His research interests center on bioinformatics, next-generation sequencing (NGS) analysis, machine learning, data visualization, and reproducible research. He develops and maintains several widely used open-source tools including Sequana (NGS pipelines), BioServices (biological web services), Bioconvert (format conversion), Sequanix (GUI for Snakemake), and GDSCTools (pharmacogenomics). He is deeply committed to promoting reproducibility in computational research through initiatives like reprohackathons. The recent publications reflect a strong trend in computational biology, with a focus on developing bioinformatics methodologies, improving data analysis workflows, and applying these tools to diverse biological problems such as fungal pathogenesis, cancer pharmacogenomics, mitochondrial metabolism, and viral evolution. The work spans genomics, transcriptomics, systems biology, and software engineering. He has contributed to numerous scientific software projects as Principal Investigator, including Sequana, Bioconvert, GDSCTools, DREAMTools, and Sequanix. He has also taught courses in scientific programming with Python and reproducible data analysis at the Institut Pasteur. His collaborative network includes researchers from EMBL-EBI, Sanger Institute, INRIA, and international partners within the Pasteur Network. The SALSA group hosts master’s students and visiting researchers annually.

• Immunology
• Genetics
• Dermatology
• +2 more

Michele Boniotto is a researcher at the University of Verona's Department of Molecular and Translational Medicine, focusing on immunology, genetics, and dermatology. His work spans molecular mechanisms in skin diseases and evolutionary aspects of host defense peptides. Research Focus Dr. Boniotto's research examines: Genetic factors in hidradenitis suppurativa Beta-defensin evolution and function Aquaporin-3 role in skin homeostasis Photobiomodulation therapies HLA-DR expression in septic shock His publications show interdisciplinary approaches combining molecular biology, clinical dermatology, and bioinformatics to understand complex disease mechanisms. Scientific Contributions 2025: Keratin filament-melanin interactions 2025: Polygenic risk scoring for HS 2024: Aquaporin-3 dysregulation in HS 2023: NCSTN mutations in familial HS 2022: Holistic HS health records 2020: Photobiomodulation for HS

• Genetics
• Metabolism
• Liver Diseases
• +5 more

Professor Stefano Romeo leads the Human Translational Genetics group at Karolinska Institutet's Department of Medicine, Huddinge, where his research bridges genetics, metabolism, and clinical medicine to address metabolic diseases. His work focuses on uncovering genetic and molecular mechanisms underlying liver diseases, diabetes, and cardiovascular conditions through innovative translational approaches. Professor Romeo's research has significantly advanced our understanding of metabolic dysfunction-associated steatotic liver disease (MASLD), identifying key genetic variants including PNPLA3 and MBOAT7 genes. He pioneered the development of multilineage 3D in vitro models for fatty liver disease and discovered a protective genetic variant in the PSD3 gene. His landmark achievement is the identification of two distinct MASLD types with different cardiometabolic risk profiles using compartmentalized polygenic risk scores, which has major implications for targeted treatment approaches. In cardiovascular research, Professor Romeo has developed machine learning algorithms for diagnosing familial hypercholesterolemia and elucidated the role of lipoprotein(a) as an independent cardiovascular risk factor. His integrated approach combines genomics, bioinformatics, molecular biology, and clinical investigations to translate discoveries into practical applications. Research Focus Areas: Genetic basis of metabolic liver diseases Cardiometabolic risk stratification 3D disease modeling and therapeutic testing Polygenic risk scoring for precision medicine Molecular pathways in lipid metabolism Professor Romeo's work has resulted in numerous high-impact publications in journals including Nature Medicine and Journal of Hepatology, demonstrating his leadership in translating genetic insights into improved disease prediction, prevention, and therapeutic outcomes for patients with metabolic disorders.

Achim KramerView profile

Professor

• Chronobiology
• Circadian Rhythms
• Molecular Biology
• +3 more

Achim Kramer serves as Professor of Chronobiology (W2, tenured) at Charité - Universitätsmedizin Berlin, where he chairs the independent Research Unit for Chronobiology within the Institute of Medical Immunology. His academic career spans molecular chronobiology research and teaching since 2002, with significant contributions to understanding circadian clock mechanisms in mammals. His educational background includes a Biochemistry degree from Freie Universität Berlin (1988-1993), a Ph.D. in Biochemistry (summa cum laude, 1996) from Humboldt Universität zu Berlin, and piano training at Berlin's Hochschule der Künste (1990-1994). Postdoctoral work included research at Harvard Medical School (1999-2001) under Charles Weitz and positions at IRBM Rome and Charité. Dr. Kramer's research centers on molecular mechanisms of circadian clocks, with expertise in protein interactions (CRY1-PER2), post-translational modifications, peripheral tissue clocks (macrophages, skin), and translational applications like circadian blood biomarkers. His work bridges structural biology, immunology, and sleep medicine to address how biological timing affects health and disease. Analysis of his publications reveals consistent focus on circadian molecular machinery across diverse biological contexts, with increasing translational emphasis in recent years on diagnostic applications and tissue-specific clock functions. His structural work on cryptochromes and phosphorylation mechanisms underpins fundamental understanding of clock regulation. Key honors include the Heinz-Maier-Leibnitz Award (DFG, 2002), Brooks Fellowship (Harvard, 2001), multiple Teaching Awards for Medical Neurosciences (2010-2015), and a Young Researcher's Award from Charité (1998). He leads the Chronobiology Research Unit within Charité's Institute of Medical Immunology, participating in the SFB/TRR186 consortium on molecular switches. His service includes chairing the 2015 Gordon Research Conference on Chronobiology, editorial roles at PLoS Genetics and Journal of Biological Rhythms, and leadership positions in the Society for Research on Biological Rhythms and European Biological Rhythms Society.

Aviv BergmanView profile

Professor

• Evolutionary Biology
• Developmental Biology
• Computational Biology
• +5 more

Aviv Bergman is a Professor at Albert Einstein College of Medicine, holding appointments in the Department of Systems & Computational Biology, Department of Pathology, and Dominick P. Purpura Department of Neuroscience. He is also Founding Chairman of the Department of Systems & Computational Biology and Director of the Albert Einstein Institute for Advanced Study in the Life Sciences. His research integrates computational, mathematical, and experimental approaches with philosophical frameworks (phenomenology, hermeneutics, pragmatism) to study evolutionary and developmental systems biology, focusing on complex traits, biological networks, and the interplay between function, organization, and agency in living systems. Prior publications highlight his work on evolutionary capacitance, gene network topology, developmental canalization, and genome-wide amino acid patterns. He emphasizes iterative refinement of theoretical models through empirical data validation.

Mary MillerView profile

Professor

• Genetics
• Microbiology
• Cancer Biology
• +6 more

Mary Miller is a Professor of Biology at Rhodes University, specializing in cell cycle regulation and cancer biology. Her research focuses on the molecular mechanisms governing eukaryotic cell division, particularly cyclin protein dynamics and DNA damage responses. B.A., University of Tennessee Ph.D., University of Virginia (Genetics, Microbiology, Cell Biology) Her laboratory investigates how the anticancer drug KP1019 induces cell cycle arrest in Saccharomyces cerevisiae , with implications for oncogenic processes in humans. Key areas include: Genome-wide transcriptional analysis Cell division cycle coordination Protein localization mechanisms Chemotherapeutic drug effects Recent publications highlight KP1019's impact on DNA damage responses and educational initiatives in yeast genetics. Collaborations include work with Pam Hanson and Laura Stultz.

David LynnView profile

Professor

• Systems immunology
• Microbiota
• Vaccines
• +12 more

Professor David Lynn is a leading academic in Systems Immunology at Flinders University and Scientific Director of the SA Genomics Centre, with affiliations to the South Australian Health and Medical Research Institute (SAHMRI) and College of Medicine and Public Health. He has held these positions since 2020 and 2019, respectively. BA (Trinity College Dublin, Genetics; 2000) MSc (University of Ottawa, Bioinformatics & Bacterial Genomics; 2001) PhD (University College Dublin, Immunology; 2004) His research interests focus on systems immunology, exploring how microbes (pathogenic and commensal) modulate immune responses in contexts such as infection, vaccination, and cancer therapies. He integrates computational modeling, bioinformatics, and preclinical mouse models to advance understanding of trained immunity and vaccine mechanisms. Recent research trends show his work spans vaccine responses, microbiota interactions, and genomics. Notable projects include the Gates Foundation-funded BRACE trial on BCG vaccine effects against COVID-19 and NHMRC-funded studies on microbiota's role in vaccination. His scientific awards include: 2023-2028: BioPlatforms Australia National Research Infrastructure funding 2023-2024: GPN Vaccines Collaborative Research Agreement 2023-2028: South Australian Government NCRIS Co-investment Grant 2023-2026: NHMRC Ideas Grant on gut microbiota and vaccine responses 2023-2025: ARC Discovery Project on androgen receptor and lipid metabolism He supervises research teams and contributes to clinical studies and genomics infrastructure development, with grants exceeding $30 million from NHMRC, GSK, and Cancer Australia. His work aligns with UN SDGs in health and well-being, reduced inequalities, and industry innovation.

• Statistics
• Machine Learning
• Functional Data Analysis
• +3 more

Anton Rask Lundborg is a Postdoctoral Research Fellow at the Department of Mathematical Sciences, University of Copenhagen. He works in the areas of Statistics, Machine Learning, and Functional Data Analysis. Key research areas: Statistics, Machine Learning, Functional Data Analysis, Causal Inference, Bioinformatics, Nonparametric Statistics Research groups: SPT (Statistical Learning Theory), CoCaLa (Collaborative Causal Learning) His recent work focuses on causal feature selection, variable significance testing, and functional data analysis applications. Publications span journals like Journal of the American Statistical Association , Briefings in Bioinformatics , and Annals of Statistics . Methodological innovations include the Projected Covariance Measure and conditional independence testing in Hilbert spaces. Explore his full research profile and publications via ORCID or the University of Copenhagen's Mathematical Sciences website .

Gilles PeslherbeView profile

Professor

• Computational Chemistry
• Molecular and Reaction Dynamics
• Nanomaterials and Materials Engineering
• +8 more

Gilles Peslherbe is a Professor at Concordia University, cross-appointed in the departments of Chemistry and Biochemistry , Physics , and Chemical and Materials Engineering . He leads the Centre for Research in Molecular Modeling (CERMM) and supervises graduate students in programs spanning Chemical Engineering, Chemistry, Physics, and Nanoscience. PhD in Physical Chemistry with Minor in Computer Engineering (Wayne State University, USA) Diplôme d'Ingénieur Chimiste (Ecole Supérieure de Chimie Industrielle de Lyon, France) His research integrates computational chemistry , quantum mechanics , and machine learning to model chemical processes in extreme conditions, drug delivery systems, and environmental impact assessments. Collaborative projects include studies on spin catalysis , nanostructured materials , and RNA structure fundamentals . Recent publications highlight applications of artificial intelligence in therapeutics development , density-functional theory in nanomaterials , and ultrasfast spectroscopy in electron solvation . His work bridges quantum computing and biological simulations . Teaching includes courses on quantum theory , computational chemistry , and statistical mechanics . He actively seeks students for ongoing projects in chemical interactions in extreme conditions and environmental remediation .

Catherine BachewichView profile

Adjunct Associate Professor

• Cell Cycle Regulation
• Fungal Pathogenesis
• Developmental Biology
• +4 more

Catherine Bachewich is an Adjunct Associate Professor in the Department of Biology at Concordia University. Her research focuses on the regulation of the cell cycle, development, and virulence in fungi, particularly Candida albicans and Aspergillus nidulans. She investigates how cell cycle signals coordinate with differentiation and polar morphogenesis, aiming to identify novel drug targets for pathogen control. Her research programs include: Studying cell cycle control in Candida albicans, emphasizing the G1/S transition, mitosis, and hyphal development. Exploring the role of the polo-like kinase PLKA in mitotic regulation and sexual development in Aspergillus nidulans, revealing its evolutionary distinctness and novel functions. Bachewich's work has uncovered unique regulatory mechanisms in fungal pathogens, contributing to understanding their pathogenicity and potential therapeutic strategies. Her recent publications highlight interdisciplinary approaches in fungal genetics, cell cycle signaling, and morphogenesis.

Aurora MartinezView profile

Professor

• Structural Biology
• Drug Discovery
• Neurometabolic Disorders
• +7 more

Aurora Martinez is a Professor in the Department of Biomedicine at the University of Bergen, Faculty of Medicine. She leads the Biorecognition research group, focusing on the structural and functional aspects of biomolecules in neurometabolic disorders such as phenylketonuria (PKU) and dopamine synthesis defects. She is also a partner in the KG Jebsen Centre for Neuropsychiatric Disorders and a Toppforsk-funded project on the Arc protein, a master regulator of synaptic plasticity. Position: Professor Institution: University of Bergen Department: Department of Biomedicine Research Group: Biorecognition Email: aurora.martinez@uib.no Her research integrates structural biology, molecular recognition, and drug discovery to develop therapeutic strategies for genetic and neurodegenerative diseases. Key areas include tyrosine hydroxylase regulation, mitochondrial dysfunction in dopaminergic cells, and neurotransmitter transport mechanisms. She employs biochemical, cellular, and computational approaches to understand disease mechanisms and identify novel therapeutics. The recent publications (2023–2025) reflect a strong trend toward understanding dopamine-related pathways, protein stabilization, and therapeutic interventions in Parkinsonism and related disorders. Themes include chaperone-mediated protein stabilization, high-throughput screening for VMAT2 modulators, and computational tools for drug discovery. The work combines experimental validation with translational applications in neurodegenerative models. She has supervised multiple Master’s students, including Md. Ekhtear Mahmud, Sofie Breisnes Wormdahl, and Kristine Kippersund Brokstad, indicating active mentorship and training roles. Her involvement in large-scale collaborative projects highlights leadership and interdisciplinary engagement. While no specific awards are listed, her participation in prestigious programs like Toppforsk and the KG Jebsen Centre underscores recognition and funding success. She has no listed grants explicitly, but project affiliations suggest competitive funding support. Her research group maintains strong technical capabilities in protein analysis, cellular screening, and structural modeling. The Martinez Lab is actively involved in both fundamental and applied research, with future directions likely to expand into gene therapy, precision medicine for metabolic disorders, and neuroprotective strategies.

Maria RoblesView profile

Professor

• Chronobiology
• Circadian Rhythms
• Sleep Research
• +9 more

Prof. Dr. Maria Robles is a full Professor and Head of the Systems Chronobiology research group at the Institute of Medical Psychology, Ludwig-Maximilians-Universität München (LMU), Faculty of Medicine. She leads a dynamic research lab focused on circadian rhythms, sleep, and their molecular underpinnings in health and disease, using cutting-edge quantitative proteomics and mass spectrometry as core methodologies. Her research spans multiple domains, including Circadian regulation of metabolism Molecular mechanisms of sleep and synaptic function Circadian clock dysfunction in diseases such as pancreatic cancer Development of novel proteomic methods (e.g., DIA, multi-omics integration) The analysis of her 15 most recent publications reveals a strong trend toward integrating proteomics with systems biology to dissect temporal dynamics in mammalian tissues. Her work frequently explores post-translational modifications, particularly phosphorylation and ubiquitination, in circadian and sleep contexts, with increasing translational focus on cancer biology and therapeutic targeting. She actively mentors PhD students and postdoctoral researchers, contributing to training the next generation of scientists in chronobiology and proteomics. Her lab is affiliated with the Biomedical Center (BMC) at LMU and is equipped with state-of-the-art instrumentation, including Orbitrap and Q-Exactive mass spectrometers, supported by DFG and LMU funding. She collaborates extensively, notably with Dieter Saur (TUM) on pancreatic cancer research.

• Precision Medicine
• Medical Genetics
• Genomics
• +4 more

Prof. Dr. Christiane Gertrud Zweier is a faculty member at the Bern Center for Precision Medicine (BCPM), University of Bern, Switzerland. She contributes to advancing research in precision medicine with a focus on genetic and molecular approaches to personalized healthcare. Her research interests lie primarily in the domains of medical genetics, genomics, and translational research, particularly in the context of rare diseases and molecular diagnostics. The work aligns with the mission of BCPM to integrate cutting-edge genomic technologies into clinical practice for improved patient outcomes. The trends in her research, inferred from institutional focus, emphasize precision diagnostics, data-driven medicine, and interdisciplinary collaboration between clinical and research teams. This reflects a strong orientation toward bioinformatics, systems biology, and functional genomics in a clinical setting. Email: christiane.zweier@insel.ch Phone: +41 31 632 94 94 There is no public information available about scientific awards, student mentorship, grants, or specific research teams led by Prof. Zweier in the provided text. However, her affiliation with BCPM suggests active participation in collaborative research projects within the precision medicine framework.

Lisa M. CoussensView profile

Professor

• Tumor Immunology
• Cancer Microenvironment
• Inflammation in Cancer
• +3 more

Lisa M. Coussens, PhD, is Chairwoman of the Department of Cell, Developmental & Cancer Biology and Interim Director of the Knight Cancer Institute at Oregon Health & Science University (OHSU), where she holds the Hildegard Lamfrom Endowed Chair in Basic Science. Her research program investigates immune cell functions in solid tumor development, with emphasis on how leukocytes influence cancer progression and therapeutic responses. Using preclinical models of mesothelioma, breast, pancreatic, and head/neck cancers, her lab identifies immunotherapy targets that have advanced to clinical trials for metastatic cancers. Education B.A., San Francisco State University, 1980 Ph.D., University of California, 1993 Postdoctoral Fellowship, University of California San Francisco (Douglas Hanahan Lab) Research Focus Dr. Coussens leads a translational research program examining how immune cells regulate tumor development and therapy responses. Her work integrates molecular oncology, immunology, and preclinical modeling to identify: 1) Immune pathways co-opted by developing tumors, 2) Mechanisms of leukocyte-mediated therapy resistance, and 3) Biomarkers for immunotherapy response. Current work emphasizes spatial analysis of tumor-immune interactions using multiplexed imaging and computational approaches. Her recent publications reflect strong emphasis on tumor microenvironment dynamics, immunotherapy mechanisms, and translational applications in pancreatic, breast, and head/neck cancers. Studies frequently incorporate spatial biology techniques, clinical correlation analyses, and novel therapeutic combinations targeting immune pathways. Honors & Awards National Academy of Sciences Member (2023) National Academy of Medicine Member (2024) AACR President (2022-2023) Susan G. Komen Brinker Award (2018) Fellow of AACR Academy (2019) Fellow of AAAS (2018) Rosalind E. Franklin Award, NCI (2015) Honorary Doctorate, University of Buenos Aires (2018) Princess Takamatsu Memorial Lectureship (2018) European Academy of Tumor Immunology Career Award (2018) Gertrude B. Elion Award (2001) Charlotte Friend Lectureship (2012) Margaret L. Kripke Legend Award (2023) Johns Hopkins Heroine of Public Health (2024) Fellow of Academy of ImmunoOncology (2022) Dr. Coussens directs translational research programs at OHSU's Knight Cancer Institute and leads multidisciplinary collaborations investigating tumor-immune crosstalk. Her laboratory develops innovative preclinical platforms for evaluating combination immunotherapies.

Katelyn ByrneView profile

Assistant Professor

• Pancreatic Cancer
• Immunotherapy
• Tumor Microenvironment
• +4 more

Katelyn Byrne is an Assistant Professor at Oregon Health and Science University (OHSU) in the Cell, Developmental and Cancer Biology department, affiliated with the Knight Cancer Institute and Brenden-Colson Center for Pancreatic Care. Her research focuses on the immunobiology of pancreatic cancer, particularly mechanisms bridging innate and adaptive immunity to enhance immunotherapy efficacy. Education: B.A. (2007) from Boston University, Ph.D. (2013) from Dartmouth College, and postdoctoral training as a Senior Parker Fellow. Her work leverages genetically engineered mouse models of pancreatic cancer to study tumor microenvironment dynamics , with clinical translation in immunotherapy trials. Key contributions include CD40 agonism for CD4+ T cell-mediated tumor rejection, immune checkpoint blockade synergy, and spatial transcriptomics for infiltrate heterogeneity. Recent articles (2024) highlight machine learning in immune profiling and MHC class I-deficient tumor targeting. Dr. Byrne is a recipient of the American Cancer Society Post-doctoral Fellowship and Senior Parker Fellowship . She mentors graduate students Margaret Haerr and Yi Zhang in her lab, which collaborates across OHSU’s cancer research centers. Current projects aim to develop novel immunotherapy combinations and T cell infiltration strategies for pancreatic cancer.